Jochen Reiser
A5076816264- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Genetic and Kidney Cyst Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- COVID-19 Clinical Research Studies
- Complement system in diseases
- Renal and related cancers
- Renal Transplantation Outcomes and Treatments
- Vasculitis and related conditions
- Pancreatic function and diabetes
- Protease and Inhibitor Mechanisms
- Autoimmune Bullous Skin Diseases
- Systemic Lupus Erythematosus Research
- Blood Coagulation and Thrombosis Mechanisms
- Ion Transport and Channel Regulation
- Ion Channels and Receptors
- Dialysis and Renal Disease Management
- Platelet Disorders and Treatments
- Acute Kidney Injury Research
- Diabetes and associated disorders
- Long-Term Effects of COVID-19
- Biomedical Research and Pathophysiology
- Cell Adhesion Molecules Research
- Microscopic Colitis
- Lipid metabolism and disorders
The University of Texas Medical Branch at Galveston
2024-2025
Otto-von-Guericke University Magdeburg
2025
Rush University Medical Center
2015-2024
Michigan Medicine
2024
Rush University
2012-2023
University of Toronto
2023
Copenhagen University Hospital
2022
Hvidovre Hospital
2022
University of Michigan
2000-2022
University General Hospital Attikon
2022
Recent molecular insights have established the podocyte as a key component of glomerular filtration barrier, and hence an important common pathway in proteinuric diseases. A conditionally immortalized human cell line has been developed by transfection with temperature-sensitive SV40-T gene. These cells proliferate at "permissive" temperature (33 degrees C). After transfer to "nonpermissive" (37 C), they entered growth arrest expressed markers differentiated vivo podocytes, including novel...
<h3>Importance</h3> The US is currently an epicenter of the coronavirus disease 2019 (COVID-19) pandemic, yet few national data are available on patient characteristics, treatment, and outcomes critical illness from COVID-19. <h3>Objectives</h3> To assess factors associated with death to examine interhospital variation in treatment for patients <h3>Design, Setting, Participants</h3> This multicenter cohort study assessed 2215 adults laboratory-confirmed COVID-19 who were admitted intensive...
Synaptopodin is an actin-associated protein of differentiated podocytes that also occurs as part the actin cytoskeleton postsynaptic densities (PSD) and associated dendritic spines in a subpopulation exclusively telencephalic synapses. Amino acid sequences determined purified rat kidney forebrain synaptopodin derived from human mouse brain cDNA clones show no significant homology to any known protein. In particular, does not contain functional domains found receptor-clustering PSD proteins....
Kidney podocytes and their slit diaphragms form the final barrier to urinary protein loss. This explains why podocyte injury is typically associated with nephrotic syndrome. The present study uncovered an unanticipated novel role for costimulatory molecule B7-1 in as inducible modifier of glomerular permselectivity. was found genetic, drug-induced, immune-mediated, bacterial toxin–induced experimental kidney diseases clinical significance our results underscored by observation that...
NPHS2 was recently identified as a gene whose mutations cause autosomal recessive steroid-resistant nephrotic syndrome. Its product, podocin, is new member of the stomatin family, which consists hairpin-like integral membrane proteins with intracellular NH2- and COOH-termini. Podocin expressed in glomerular podocytes, but its subcellular distribution interaction other are unknown. Here we show, by immunoelectron microscopy, that podocin localizes to podocyte foot process membrane, at...
Therapies that improve survival in critically ill patients with coronavirus disease 2019 (COVID-19) are needed. Tocilizumab, a monoclonal antibody against the interleukin 6 receptor, may counteract inflammatory cytokine release syndrome severe COVID-19 illness.
Rituximab treatment in high-risk patients with focal segmental glomerulosclerosis directly affects podocyte function and is linked to reduced incidence of recurrent proteinuria after kidney transplantation.
NPHS2 was recently identified as a gene whose mutations cause autosomal recessive steroid-resistant nephrotic syndrome. Its product, podocin, is new member of the stomatin family, which consists hairpin-like integral membrane proteins with intracellular NH2- and COOH-termini. Podocin expressed in glomerular podocytes, but its subcellular distribution interaction other are unknown. Here we show, by immunoelectron microscopy, that podocin localizes to podocyte foot process membrane, at...
The glomerular slit diaphragm between podocyte foot processes shares typical morphologic features with an adherens junction. Differentiated cultured podocytes form cellular structures comparable to filtration slits in vivo. At those sites, zonula occludens-1 (ZO-1) was coexpressed P-cadherin as well alpha-, beta-, and gamma-catenin. In situ, detected at the association ZO-1 shown by confocal microscopy immunogold double labeling electron microscopy. expression vivo vitro confirmed reverse...
Relatively high plasma levels of soluble urokinase-type plasminogen activator receptor (suPAR) have been associated with focal segmental glomerulosclerosis and poor clinical outcomes in patients various conditions. It is unknown whether elevated suPAR normal kidney function are future decline the estimated glomerular filtration rate (eGFR) incident chronic disease.We measured 3683 persons enrolled Emory Cardiovascular Biobank (mean age, 63 years; 65% men; median level, 3040 pg per...
Steroid-resistant nephrotic syndrome (SRNS) is a frequent cause of end-stage renal failure. Identification single-gene causes SRNS has generated some insights into its pathogenesis; however, additional genes and disease mechanisms remain obscure, continues to be treatment refractory. Here we have identified 6 different mutations in coenzyme Q10 biosynthesis monooxygenase (COQ6) 13 individuals from 7 families by homozygosity mapping. Each mutation was linked early-onset with sensorineural...
Overexpression of soluble urokinase receptor (suPAR) causes pathology in animal models similar to primary FSGS, and one recent study demonstrated elevated levels serum suPAR patients with the disease. Here, we analyzed circulating two cohorts children adults biopsy-proven FSGS: 70 from North America–based FSGS clinical trial (CT) 94 PodoNet, Europe-based consortium studying steroid-resistant nephrotic syndrome. Circulating were 84.3% 55.3% CT PodoNet cohorts, respectively, compared 6%...
Pretransplant antibodies, particularly anti-CD40, correlate with risk of recurrent focal segmental glomerulosclerosis after kidney transplant.
Acute kidney injury is common, with a major effect on morbidity and health care utilization. Soluble urokinase plasminogen activator receptor (suPAR) signaling glycoprotein thought to be involved in the pathogenesis of disease. We investigated whether high level suPAR predisposed patients acute multiple clinical contexts, we used experimental models identify mechanisms by which acts assess it as therapeutic target.We measured plasma levels preprocedurally who underwent coronary angiography...
Significance Immunotherapy has revolutionized cancer treatment, yielding unprecedented long-term responses and survival. However, a significant proportion of patients remain refractory, which correlates with the absence immune-infiltrated (“hot”) tumors. Here, we observed that FDA-approved unadjuvanted seasonal influenza vaccines administered via intratumoral injection not only provide protection against active virus lung infection, but also reduce tumor growth by increasing antitumor CD8 +...