A5081811761- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Sodium Intake and Health
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Gut microbiota and health
- Ion Transport and Channel Regulation
- Reproductive System and Pregnancy
- Eicosanoids and Hypertension Pharmacology
- Nutritional Studies and Diet
- Dialysis and Renal Disease Management
- Nitric Oxide and Endothelin Effects
- Atherosclerosis and Cardiovascular Diseases
- Renal Diseases and Glomerulopathies
- Complement system in diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Blood Pressure and Hypertension Studies
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Apelin-related biomedical research
- Electrolyte and hormonal disorders
- Inflammatory mediators and NSAID effects
- Vitamin D Research Studies
Max Delbrück Center
2016-2025
Charité - Universitätsmedizin Berlin
2016-2025
Humboldt-Universität zu Berlin
2004-2025
Freie Universität Berlin
2000-2025
German Centre for Cardiovascular Research
2015-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2017-2024
Helios Hospital Berlin-Buch
2007-2024
Kantonsspital Baselland
2024
Helmholtz Association of German Research Centres
2021
Mahle (Austria)
2021
Antibodies against HLA antigens cause refractory allograft rejection with vasculopathy in some, but not all, patients.We studied 33 kidney-transplant recipients who had vascular rejection. Thirteen donor-specific anti-HLA antibodies, whereas 20 did not. Malignant hypertension was present 16 of the patients without 4 whom seizures. The remaining 17 no malignant hypertension. We hypothesized that activating antibodies targeting angiotensin II type 1 (AT1) receptor might be involved.Activating...
Arterial hypertension and its organ sequelae show characteristics of T cell-mediated inflammatory diseases. Experimental anti-inflammatory therapies have been shown to ameliorate hypertensive end-organ damage. Recently, the CANTOS study (Canakinumab Antiinflammatory Thrombosis Outcome Study) targeting interleukin-1β demonstrated that therapy reduces cardiovascular risk. The gut microbiome plays a pivotal role in immune homeostasis health. Short-chain fatty acids (SCFAs) are produced from...
Abstract —We recently reported that the activation of nuclear factor-κB (NF-κB) promotes inflammation in rats harboring both human renin and angiotensinogen genes (double-transgenic [dTGR]). We tested hypothesis antioxidant pyrrolidine dithiocarbamate (PDTC) inhibits NF-κB ameliorates renal cardiac end-organ damage. dTGR feature hypertension, severe damage, a 40% mortality rate at 7 weeks. Electrophoretic mobility shift assay showed increased DNA binding activity hearts kidneys dTGR. Chronic...
Steroid-resistant nephrotic syndrome (SRNS) is a frequent cause of end-stage renal failure. Identification single-gene causes SRNS has generated some insights into its pathogenesis; however, additional genes and disease mechanisms remain obscure, continues to be treatment refractory. Here we have identified 6 different mutations in coenzyme Q10 biosynthesis monooxygenase (COQ6) 13 individuals from 7 families by homozygosity mapping. Each mutation was linked early-onset with sensorineural...
The skin interstitium sequesters excess Na+ and Cl- in salt-sensitive hypertension. Mononuclear phagocyte system (MPS) cells are recruited to the skin, sense hypertonic electrolyte accumulation activate tonicity-responsive enhancer-binding protein (TONEBP, also known as NFAT5) initiate expression secretion of VEGFC, which enhances clearance via cutaneous lymph vessels increases eNOS blood vessels. It is unclear whether this local MPS response osmotic stress important systemic pressure...
High dietary salt intake is associated with hypertension; the prevalence of salt-sensitive hypertension increases age. We hypothesized that tissue Na + might accumulate in hypertensive patients and aging be accompanied by deposition tissue. implemented 23 magnetic resonance imaging to measure content soft tissues vivo earlier, but had not studied essential hypertension. report on a cohort 56 healthy control men women, 57 women The ages ranged from 22 90 years. measurements were made at level...
Eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) protect against cardiovascular disease by largely unknown mechanisms. We tested the hypothesis that EPA DHA may compete with arachidonic (AA) for conversion cytochrome P450 (CYP) enzymes, resulting in formation of alternative, physiologically active, metabolites. Renal hepatic microsomes, as well various CYP isoforms, displayed equal or elevated activities when metabolizing instead AA. CYP2C/2J isoforms converting AA to...
Hypertensive target organ damage, especially cardiac hypertrophy with heart failure and arrhythmia, is a major source of morbidity mortality. Angiotensin II, mediator hypertension has proinflammatory properties. Inflammation activation the immune system play pivotal role in pathogenesis hypertensive damage. However, immunosuppressive CD4+CD25+ regulatory T (Treg) cells damage unexplored.We conducted adoptive transfer Treg into angiotensin II-infused mice. cell recipients exhibited improved...
Background Systemic sclerosis (SSc) features autoimmunity, vasculopathy and tissue fibrosis. The renin-angiotensin endothelin systems have been implicated in A role for autoantibody-mediated receptor stimulation is hypothesised, linking three major pathophysiological consistent with SSc. Methods Serum samples from 478 patients SSc (298 the study cohort 180 two further independent cohorts), 372 healthy subjects 311 control-disease were tested antibodies against angiotensin II type 1 (AT R)...
A high intake of dietary salt (NaCl) has been implicated in the development hypertension, chronic inflammation, and autoimmune diseases. We have recently shown that a proinflammatory effect boosts activation Th17 cells classical, LPS-induced macrophages (M1). Here, we examined how alternative (M2) is affected by salt. In stark contrast to M1 macrophages, blunted BM-derived mouse stimulated with IL-4 IL-13, M(IL-4+IL-13) macrophages. Salt-induced reduction was not associated increased...
Hypertension is linked to disturbed total-body sodium (Na(+)) regulation; however, measuring Na(+) disposition in the body difficult. We implemented (23)Na magnetic resonance spectroscopy ((23)Na-MR) and imaging technique ((23)Na-MRI) at 9.4T for animals 3T humans quantify content skeletal muscle skin. compared (23)Na-MRI data with actual tissue measured by chemical analysis animal human tissue. then quantified normal patients primary aldosteronism. found a 29% increase aldosteronism women...
Abstract Aims Atherosclerotic cardiovascular disease (ACVD) is a major cause of mortality and morbidity worldwide, increased low-density lipoproteins (LDLs) play critical role in development progression atherosclerosis. Here, we examined for the first time gut immunomodulatory effects microbiota-derived metabolite propionic acid (PA) on intestinal cholesterol metabolism. Methods results Using both human animal model studies, demonstrate that treatment with PA reduces blood total LDL levels....
Cytochrome P450 (CYP)-dependent metabolites of arachidonic acid (AA) contribute to the regulation cardiovascular function. CYP enzymes also accept EPA and DHA yield more potent vasodilatory potentially anti-arrhythmic metabolites, suggesting that endogenous CYP-eicosanoid profile can be favorably shifted by dietary omega-3 fatty acids. To test this hypothesis, 20 healthy volunteers were treated with an EPA/DHA supplement analyzed for concomitant changes in circulatory urinary levels AA-,...