A5058422926- Lipid metabolism and biosynthesis
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Advanced Proteomics Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Hepatitis C virus research
- Bacterial Identification and Susceptibility Testing
- Otolaryngology and Infectious Diseases
- Airway Management and Intubation Techniques
- Healthcare Systems and Public Health
- Diet, Metabolism, and Disease
- Venous Thromboembolism Diagnosis and Management
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Problem and Project Based Learning
- Optimism, Hope, and Well-being
- Molecular Biology Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Metabolism, Diabetes, and Cancer
Max Planck Institute of Molecular Cell Biology and Genetics
2018-2022
Spectroswiss (Switzerland)
2022
Max Delbrück Center
2017-2019
Charité - Universitätsmedizin Berlin
2017
Sechenov University
1999-2013
The rs641738C>T variant located near the membrane-bound O-acyltransferase domain containing 7 (MBOAT7) locus is associated with fibrosis in liver diseases, including non-alcoholic fatty disease (NAFLD), alcohol-related disease, hepatitis B and C. We aim to understand mechanism by which contributes pathogenesis of NAFLD.
Nonalcoholic fatty liver disease (NAFLD) is a common metabolic dysfunction leading to hepatic steatosis. However, NAFLD's global impact on the lipidome poorly understood. Using high-resolution shotgun mass spectrometry, we quantified molar abundance of 316 species from 22 major lipid classes in biopsies 365 patients, including nonsteatotic patients with normal or excessive weight, diagnosed NAFL (nonalcoholic liver) NASH steatohepatitis), and bearing mutations NAFLD-related protein factors....
Lipid metabolites, beyond triglycerides and cholesterol, have been shown to vast potential for applications in clinical applications, with substantial societal economical value. To successfully evolve from the current research-grade methods assays suitable routine a harmonization - if not standardization of these mass spectrometry-based workflows is necessary. Input on needs technological capabilities must be obtained all relevant stakeholders, including wet lab scientists, informaticians...
Shotgun analysis provides a quantitative snapshot of the lipidome composition cells, tissues, or model organisms; however, it does not elucidate spatial distribution lipids. Here we demonstrate that shotgun could quantify low-picomole amounts lipids isolated by laser capture microdissection (LCM) hundred micrometer-sized histological zones visualized at cryosections tissues. We identified metabolically distinct periportal (pp) and pericentral (pc) immunostaining 20 μm thick healthy mouse...
Abstract Background Metabolic alterations can serve as targets for diagnosis and cancer therapy. Due to the highly complex regulation of cellular metabolism, definite identification metabolic pathway remains challenging requires sophisticated experimentation. Methods We applied a comprehensive kinetic model central carbon metabolism (CCM) characterise reprogramming in murine liver cancer. Results show that relative differences protein abundances enzymes obtained by mass spectrometry be used...
Aim . To study features and risk factors of soft tissue's invasive streptococcal infection in surgical unit's patients: a) emm-types the most often recovered streptococcus; b) human immune response for antigens (streptolysin-O group A carbohydrate antigen); c) main patient's conditions that complicate course infection. Patients methods 101 patients with infection, which (GAS) nature, were examined. Emm-types determined by comparison emm gene sequenced part data CDC Streptococcus Laboratory....
Summary Metabolic alterations can serve as targets for diagnosis and therapy of cancer. Due to the highly complex regulation cellular metabolism, definite identification metabolic pathway remains challenging requires sophisticated experimentation. Here, we applied a comprehensive kinetic model central carbon metabolism (CCM) characterize reprogramming in murine liver We show that relative differences protein abundances enzymes obtained by mass spectrometry be used scale maximal enzyme...
Liver cancer is becoming a major health problem in western societies due to constantly rising incidence and loss of effective long-term treatment options. HIF1A frequently overexpressed human cancers as well murine tumor models considered be an attractive target for innovative therapy. While hepatoma shows evidence activated hypoxic response, the functional importance biology remains largely elusive. Using mass spectrometry we have performed detailed analysis tumor-specific proteome during...
Phlegmon of a neck represents the serious illness which is characterized by development poured pyoinflammatory process in cells spaces with fast distribution purulent zatek that caused anatomic features. The clinical picture disease doesn’t allow to establish prevalence pathological preoperative period very often, and large number important formations don’t sanify center single-stages. supervision option treatment patient positive outcome given article.
Objective The rs641738C>T variant located near the membrane-bound O-acyltransferase domain containing 7 (MBOAT7) locus is associated with fibrosis in liver diseases, including non-alcoholic fatty disease (NAFLD), alcohol-related disease, hepatitis B and C. We aim to understand mechanism by which contributes pathogenesis of NAFLD.