A5045145843- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Hepatitis C virus research
- Liver Disease and Transplantation
- Liver physiology and pathology
- Liver Diseases and Immunity
- Drug-Induced Hepatotoxicity and Protection
- Endoplasmic Reticulum Stress and Disease
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Diet and metabolism studies
- Folate and B Vitamins Research
- Lipid metabolism and disorders
- Iron Metabolism and Disorders
- Complementary and Alternative Medicine Studies
- Organ Transplantation Techniques and Outcomes
- Genomics, phytochemicals, and oxidative stress
- Eicosanoids and Hypertension Pharmacology
- Cancer, Lipids, and Metabolism
- Retinoids in leukemia and cellular processes
- Cancer, Hypoxia, and Metabolism
- Pancreatitis Pathology and Treatment
- Glutathione Transferases and Polymorphisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
University Hospital of Zurich
2015-2024
Hirslanden Klinik Beau-Site
2013-2024
QIMR Berghofer Medical Research Institute
2024
University of Zurich
2015-2023
University Hospital of Bern
2008-2018
Hirslanden Private Hospital Group
2017
University of Bern
2007-2016
Heidelberg University
1993-2015
Friedrich-Alexander-Universität Erlangen-Nürnberg
2001-2015
German Cancer Research Center
2015
A recent genome-wide study revealed an association between variation in the PNPLA3 gene and liver fat content. In addition, single-nucleotide polymorphism rs738409 (M148I) was reported to be associated with advanced alcoholic disease alcohol-dependent individuals of Mestizo descent. We therefore evaluated impact on manifestation two independent German cohorts. Genotype allele frequencies were determined 1,043 patients or without injury 376 at-risk drinkers from a population-based cohort....
•Genetic predisposition to liver fat accumulation predisposes cirrhosis and HCC.•Hepatic promotes carcinogenesis, partly via fibrosis.•Polygenic risk scores may improve HCC stratification during dysmetabolism. Background & AimsHepatocellular carcinoma (HCC) in individuals with dysmetabolism is a major unmet need. Genetic contributes non-alcoholic fatty disease (NAFLD). We aimed exploit robust polygenic (PRS) that can be evaluated the clinic gain insight into causal relationship between NAFLD...
Non-alcoholic fatty liver disease (NAFLD) is closely linked to obesity; however, 5-8% of lean subjects also have evidence NAFLD. We aimed investigate clinical, genetic, metabolic and lifestyle characteristics in Caucasian with NAFLD.Data from 187 allocated one the three groups according body mass index (BMI) hepatic steatosis on ultrasound were obtained: healthy (BMI≤25 kg/m2, no steatosis, N=71), NAFLD N=55), obese (BMI≥30 steatosis; N=61). All received a detailed clinical laboratory...
Copper has a role in antioxidant defense, lipid peroxidation, and mitochondrial function, copper deficiency been linked to atherogenic dyslipidemia. We aimed investigate the potential of availability pathogenesis nonalcoholic fatty liver disease (NAFLD).Patients with NAFLD (n=124) were compared patients chronic hepatitis C (n=50), hemochromatosis (n=35), alcoholic (n=13), autoimmune (n=11), control subjects (n=27). determined serum concentrations correlation clinical, histological,...
Abstract The vitronectin receptor integrin αvβ3 promotes angiogenesis by mediating migration and proliferation of endothelial cells, but also drives fibrogenic activation hepatic stellate cells (HSCs) in vitro. Expecting antifibrotic synergism, we studied the effect inhibition two vivo models liver fibrogenesis. Liver fibrosis was induced rats way bile duct ligation (BDL) for 6 weeks or thioacetamide (TAA) injections 12 weeks. A specific (αvβ5) inhibitor (Cilengitide) given intraperitoneally...
The pathophysiological significance of hepatic lipid accumulation in the absence significant alcohol consumption is increasingly recognised. Thus, non-alcoholic fatty liver disease (NAFLD) now considered most common cause enzyme elevation Western countries.1 It regarded as manifestation metabolic syndrome (MS), characterised by central obesity and insulin resistance (IR), resulting diabetes type 2, dyslipidaemia hypertension.2 NAFLD encompasses mild steatosis to steatohepatitis...
Oxidative stress is thought to play a major role in the pathogenesis of hepatocellular cancer (HCC), frequent complication alcoholic liver disease (ALD). However, underlying mechanisms are poorly understood. In hepatocytes ALD patients, we recently detected by immunohistochemistry significantly increased levels carcinogenic etheno-DNA adducts that formed reaction lipid peroxidation product, 4-hydroxynonenal (4-HNE) with nucleobases. current study, show protein-bound 4-HNE and both strongly...
A large prospective, open-label, randomized trial evaluated conversion from calcineurin inhibitor (CNI)- to sirolimus (SRL)-based immunosuppression for preservation of renal function in liver transplantation patients. Eligible patients received allografts 6-144 months previously and maintenance with CNI (cyclosporine or tacrolimus) since early posttransplantation. In total, 607 were (2:1) abrupt (<24 h) SRL (n = 393) continuation up 6 years 214). Between-group changes baseline-adjusted mean...