Bernhard Paulweber
A5025058942- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genetic Associations and Epidemiology
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Peroxisome Proliferator-Activated Receptors
- Metabolism, Diabetes, and Cancer
- Cardiovascular Disease and Adiposity
- Folate and B Vitamins Research
- Iron Metabolism and Disorders
- Cholesterol and Lipid Metabolism
- Diabetes Management and Research
- Lipid metabolism and disorders
- Cancer, Lipids, and Metabolism
- Metabolism and Genetic Disorders
- Nutrition, Genetics, and Disease
- RNA modifications and cancer
- Liver Disease and Transplantation
- Hormonal Regulation and Hypertension
- Diabetes and associated disorders
- Renal Diseases and Glomerulopathies
Paracelsus Medical University
2016-2025
Universitätskliniken Salzburg
2018-2025
Salzburger Landeskliniken
2007-2024
University of Salzburg
2005-2024
Paracelsus Medizinische Privatuniversität
2012-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Ospedale Maggiore
2022
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2022
Austrian Atherosclerosis Society
2017
University of California, San Diego
2014
The prevalence and socioeconomic burden of type 2 diabetes (T2DM) associated co-morbidities are rising worldwide.This guideline provides evidence-based recommendations for preventing T2DM.A European multidisciplinary consortium systematically reviewed the evidence on effectiveness screening interventions T2DM prevention using SIGN criteria.Obesity sedentary lifestyle main modifiable risk factors. Age ethnicity non-modifiable Case-finding should follow a step-wise procedure questionnaires...
Obesity and associated metabolic disorders have become highly prevalent diseases worldwide, the human gut microbiota, due to its influence on host energy metabolism, has been attributed an important role therein. This pilot study explores host-microbiota relationships in men women affected by various types of glucose metabolism disorder. Among 20 individuals aged 58 71 years with either normal tolerance, prediabetes, or type 2 diabetes mellitus bacterial communities were compared based...
1.1. Cardiovascular disease and dyslipidemia: prevalence global economic impact Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, reaching 31% deaths in 2012 [1]. In particular, atherosclerosis ischemic heart (IHD) main causes premature death Europe responsible for 42% women 38% men under 75 years old [2]. The impact CVD is estimated to have been US $906 billion 2015 expected rise by 22% 2030 [3]. also represent major disability developed countries. It has that...
Non-alcoholic fatty liver disease (NAFLD) is closely linked to obesity; however, 5-8% of lean subjects also have evidence NAFLD. We aimed investigate clinical, genetic, metabolic and lifestyle characteristics in Caucasian with NAFLD.Data from 187 allocated one the three groups according body mass index (BMI) hepatic steatosis on ultrasound were obtained: healthy (BMI≤25 kg/m2, no steatosis, N=71), NAFLD N=55), obese (BMI≥30 steatosis; N=61). All received a detailed clinical laboratory...
Significance Statement Although studies show that diabetic kidney disease has a heritable component, searches for the genetic determinants of this complication diabetes have had limited success. In study, new international genomics consortium, JDRF funded Diabetic Nephropathy Collaborative Research Initiative, assembled nearly 20,000 samples from participants with type 1 diabetes, and without disease. The authors found 16 disease–associated loci at genome-wide significance. strongest signal...
Non-alcoholic fatty liver disease (NAFLD) and alcohol-related (ALD) cannot reliably be distinguished by routine diagnostics, the role of alcohol consumption in metabolic dysfunction-associated (MAFLD) remains unclear. We investigated patients with presumed NAFLD ALD using novel objective markers.
Finerenone reduced the risk of kidney and cardiovascular events in people with chronic disease (CKD) type 2 diabetes FIDELIO-DKD FIGARO-DKD phase 3 studies. Effects finerenone on outcomes patients taking sodium-glucose cotransporter inhibitors (SGLT2is) were evaluated a prespecified pooled analysis these studies.Patients urine albumin-to-creatinine ratio (UACR) ≥30 to ≤5,000 mg/g estimated glomerular filtration rate (eGFR) ≥25 mL/min/1.73 m2 randomly assigned or placebo; SGLT2is permitted at...
Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by systemic inflammation. While RA primarily affects the joints, its effects may lead to an increased cerebro- and cardiovascular risk. Atherosclerosis of carotid arteries significant risk factor for cerebrovascular events serves as surrogate marker This study explores link between artery atherosclerosis with data from Paracelsus 10,000 Study. Baseline assessments were conducted on individuals randomly selected Salzburg...
Abstract A common 936 C/T polymorphism in the gene for vascular endothelial growth factor (VEGF) has been associated with VEGF plasma levels. In our case‐control study, we investigated role of this breast cancer risk. genotype was determined 500 women and sex‐ age‐matched healthy control subjects. Carriers a 936T‐allele were more frequent among controls (29.4%) than patients (17.6%; p = 0.000014). The odds ratio carriers 0.51 (95% confidence interval 0.38–0.70). Additionally, levels 21...
When we ask people what they value most, health is usually top of the list. While effective care available for many chronic diseases, fact remains that patient, tax payer and whole society: Prevention Better Than Cure.
The associations of the adiponectin (APM1) gene with parameters metabolic syndrome are inconsistent. We performed a systematic investigation based on fine-mapped single nucleotide polymorphisms (SNPs) highlighting genetic architecture and their role in modulating plasma concentrations particularly healthy population 1,727 Caucasians avoiding secondary effects from disease processes. Genotyping 53 SNPs (average spacing 0.7 kb) APM1 region 81 revealed two-block linkage disequilibrium (LD)...
Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD) and end stage renal (ESRD). Previously, we identified 16 loci for eGFR in genome-wide association studies, but associations these single nucleotide polymorphisms (SNPs) incident CKD or ESRD are unknown. We thus investigated with 26,308 individuals European ancestry free at baseline drawn from eight population-based cohorts followed median 7.2 years (including 2,122 cases defined as <60ml/min/1.73m2...
The metabolic syndrome (MetS) is associated with an increased risk for subsequent development of type 2 diabetes mellitus, cardiovascular disease, and stroke. Type increases the stroke coronary heart disease in women to a greater extent than men, thus question arises whether there are sex differences association early atherosclerosis MetS.1588 middle-aged Austrian subjects (1001 males, 587 females) were included present study. MetS was defined by criteria National Cholesterol Education...
Elevated concentrations of albumin in the urine, albuminuria, are a hallmark diabetic kidney disease and associated with an increased risk for end-stage renal cardiovascular events. To gain insight into pathophysiological mechanisms underlying we conducted meta-analyses genome-wide association studies independent replication up to 5,825 individuals European ancestry diabetes 46,061 without diabetes, followed by functional studies. Known associations variants CUBN, encoding cubilin, urinary...