A5056233798- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Kidney Stones and Urolithiasis Treatments
- Renal Transplantation Outcomes and Treatments
- Parathyroid Disorders and Treatments
- Central Venous Catheters and Hemodialysis
- Renal and Vascular Pathologies
- Renal function and acid-base balance
- Vascular Procedures and Complications
- Blood Pressure and Hypertension Studies
- Organ Transplantation Techniques and Outcomes
- Proteoglycans and glycosaminoglycans research
- Renal and related cancers
- Biomedical Research and Pathophysiology
- Pediatric Urology and Nephrology Studies
- Genetic and Kidney Cyst Diseases
- Vasculitis and related conditions
- Vascular anomalies and interventions
- Metabolism and Genetic Disorders
- Urological Disorders and Treatments
- Fibroblast Growth Factor Research
- Acute Kidney Injury Research
- Iron Metabolism and Disorders
- PI3K/AKT/mTOR signaling in cancer
Hôpital Cochin
2023
Université Paris Cité
2023
Assistance Publique – Hôpitaux de Paris
2023
University of Palermo
2009-2020
University of Verona
2010-2019
Azienda di Rilievo Nazionale ed Alta Specializzazione
2019
The University of Texas Southwestern Medical Center
2018
Azienda Ospedaliera Universitaria Integrata Verona
1998-2013
Società Italiana di Nefrologia
1980-2011
Pediatric Nephrology of Alabama
2009
To assess whether chlorambucil or cyclophosphamide may have a better therapeutic index in patients with idiopathic membranous nephropathy, we compared two regimens based on 6-mo treatment, alternating every other month methylprednisolone cyclophosphamide. Patients biopsy-proven nephropathy and nephrotic syndrome were randomized to be given (1 g intravenously for 3 consecutive days followed by oral methylprednisolone, 0.4 mg/kg per d 27 d) alternated either (0.2 30 (2.5 d). The whole...
Background. Iron deficiency (ID) is the main cause of hyporesponsiveness to erythropoietin in haemodialysis patients and its detection value since it easily corrected by intravenous iron. Markers iron supply erythron, including erythrocyte zinc protoporphyrin (Er‐ZPP), percentage hypochromic erythrocytes (Hypo), reticulocyte haemoglobin content (CHr) soluble transferrin receptor (sTfR), may be more accurate predictors ID than ferritin (Fer) saturation (TSat), but relative diagnostic power...
Elevated concentrations of albumin in the urine, albuminuria, are a hallmark diabetic kidney disease and associated with an increased risk for end-stage renal cardiovascular events. To gain insight into pathophysiological mechanisms underlying we conducted meta-analyses genome-wide association studies independent replication up to 5,825 individuals European ancestry diabetes 46,061 without diabetes, followed by functional studies. Known associations variants CUBN, encoding cubilin, urinary...
Background. Stenosis is the main cause of arteriovenous fistula (AVF) failure. It unclear, however, if surveillance for stenosis enhances AVF function and longevity there an ideal time intervention.
Background. It has been suggested that hepcidin may be useful as a tool for managing iron therapy in haemodialysis (HD) patients on erythropoiesis-stimulating agents (ESA).
To assess whether NLR pyrin domain-containing protein 3 (NLRP3) inflammasome, a multiprotein complex that mediates the activation of caspase-1 (CASP-1) and pro-inflammatory cytokines IL-18 IL-1β, could be involved in chronic inflammatory state observed kidney disease patients undergoing hemodialysis treatment (CKD-HD), we employed several biomolecular techniques including RT-PCR, western blot, FACS analysis, confocal microscopy microarray. Interestingly, peripheral blood mononuclear cells...
The epithelial to mesenchymal transition (EMT) is a multi-factorial biological mechanism involved in renal and hepatic fibrosis the IL-1 beta has been assumed as mediator of this process although data are not exhaustive. Therefore, aim our study was evaluate role cytokine EMT proximal tubular cells (HK-2) stellate (LX-2) protective/anti-fibrotic effect its inhibition by Canakinumab (a specific human monoclonal antibody targeted against IL-1beta).Both cell types were treated with (10 ng/ml)...
Testing for epidermal growth factor receptor (EGFR) mutations is an essential recommendation in guidelines metastatic non-squamous non-small-cell lung cancer, and considered mandatory European countries. However, practice, challenges are often faced when carrying out routine biomarker testing, including access to inadequate tissue samples long turnaround times (TATs).To evaluate the real-world EGFR testing practices of pathology laboratories, online survey was set up validated by Pulmonary...
Surgery is the traditional treatment for juxta-anastomotic stenoses in forearm arteriovenous fistulas (AVF), but percutaneous transluminal angioplasty (PTA) a suitable alternative. No prospective comparative trials between two have been reported to date, however. A retrospective analysis of prospectively, concurrently collected data was performed compare outcome and cost surgery PTA preemptive repair stenosis lower AVF. Sixty-four AVF with >50% venous were considered: 21 treated surgically...
In frail elderly patients, the chronic use of renal replacement therapy sometimes affords no tangible benefits and may even negatively affect their quality life (Qol), making prolonged conservative management a reasonable option.This observational, uncontrolled study was conducted on 11 end-stage disease patients over 75 years age, treatment with follow-up at least 6 months, to assess compliance Italian clinical guidelines concerning failure, comorbidities, hospital stays, several...
Medullary sponge kidney (MSK) is a renal malformation typically associated with nephrocalcinosis and recurrent calcium stones. Incomplete distal tubular acidosis, hypocitraturia, hypercalciuria are common. For stone prevention, patients MSK generally receive the standard "stone clinic" recommendations often potassium citrate (KC). However, effect on recurrence of treatment in these has never been studied.The issue was retrospectively analyzed an outpatient basis 97 radiologic diagnosis MSK:...
Summary Background and objectives: Guidelines recommend systematically screening for stenosis using various methods, but no studies so far have compared all of the options. A prospective blinded study was performed to compare performance several bedside tests during dialysis in diagnosing angiographically proven >50% fistula stenosis. Design, setting, participants, & measurements In an unselected population 119 hemodialysis patients with mature fistulas, physical examination (PE)...
Abstract Background Epithelial-mesenchymal transition of tubular cells is a widely recognized mechanism that sustains interstitial fibrosis in diabetic nephropathy (DN). The signaling FGF-2, growth factor involved this mechanism, regulated by glycosaminoglycans. Heparanase-1, an endoglycosidase cleaves heparan sulfate, implicated the pathogenesis and necessary to FGF-2 for induction transition. Well known Heparanase-1 inhibitors are heparin(s) sulodexide, low-molecular weight heparin –...
Background Mitochondria, essential eukaryotic cells organelles defined as the "powerhouse of cell" because their ability to produce vast majority energy necessary for cellular metabolism, may have a primary role in oxidative stress-related intracellular machinery associated chronic kidney disease (CKD). Methods To better assess this research assumption, we decided study key factors regulating mitochondrial metabolism CKD patients peritoneal dialysis (PD, n = 15) using several bio-molecular...
Ischemia/reperfusion (I/R) is an important cause of acute renal failure and delayed graft function, it may induce chronic damage by activating epithelial to mesenchymal transition (EMT) tubular cells. Heparanase (HPSE), endoglycosidase that regulates FGF-2 TGFβ-induced EMT, have role. Therefore, aim this study was evaluate its role in the I/R-induced pro-fibrotic machinery employing vitro vivo models.Wild type (WT) HPSE-silenced cells were subjected hypoxia reoxygenation presence or absence...