Braxton D. Mitchell
A5027947946- Genetic Associations and Epidemiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer-related molecular mechanisms research
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Rare Diseases
- Genetic and phenotypic traits in livestock
- Pancreatic function and diabetes
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Metabolism, Diabetes, and Cancer
- Acute Ischemic Stroke Management
- RNA modifications and cancer
- Diabetes Treatment and Management
- Advanced Neuroimaging Techniques and Applications
- Bone health and osteoporosis research
- Cerebrovascular and Carotid Artery Diseases
- Adipose Tissue and Metabolism
- Lipoproteins and Cardiovascular Health
- Osteoarthritis Treatment and Mechanisms
- Agriculture and Farm Safety
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Genomics and Diagnostics
- Cardiovascular Health and Risk Factors
- Obesity, Physical Activity, Diet
University of Maryland, Baltimore
2016-2025
Baltimore VA Medical Center
2014-2024
United States Department of Veterans Affairs
2015-2024
Jacksonville College
2024
Mayo Clinic in Florida
2013-2024
VA Maryland Health Care System
2007-2024
Braxton (United States)
2013-2024
University of Mary
2019-2024
University of Maryland, College Park
2003-2024
University of Baltimore
2008-2023
Many studies have shown that hyperinsulinemia and/or insulin resistance are related to various metabolic and physiological disorders including hypertension, dyslipidemia, non-insulin-dependent diabetes mellitus. This syndrome has been termed Syndrome X. An important limitation of previous they all cross sectional, thus the presence could be a consequence underlying rather than its cause. We examined relationship fasting concentration (as an indicator resistance) incidence multiple...
Although type II diabetes is associated with both microvascular and macrovascular complications, duration of severity glycemia are strongly only the former. Since prediabetic individuals hyperinsulinemia, since hyperinsulinemia may be a cardiovascular risk factor, we hypothesized that might have an atherogenic pattern factors even before onset clinical diabetes, thereby explaining relative lack association complications either glycemic or disease duration. We documented factor status 614...
Apolipoprotein C-III (apoC-III) inhibits triglyceride hydrolysis and has been implicated in coronary artery disease. Through a genome-wide association study, we have found that about 5% of the Lancaster Amish are heterozygous carriers null mutation (R19X) gene encoding apoC-III ( APOC3 ) and, as result, express half amount present noncarriers. Mutation compared with noncarriers had lower fasting postprandial serum triglycerides, higher levels HDL-cholesterol LDL-cholesterol. Subclinical...
The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium was set up to analyze brain measures and genotypes from multiple sites across the world improve power detect genetic variants that influence brain. Diffusion tensor imaging (DTI) yields quantitative sensitive development degeneration, some common may be associated with white matter integrity or connectivity. DTI measures, such as fractional anisotropy (FA) of water diffusion, useful for identifying microstructure....
Few data exist on predictors of non-insulin-dependent (type II) diabetes mellitus. We examined body mass index (BMI), ratio subscapular-to-triceps skin fold (centrality index), and fasting glucose insulin concentrations as decompensation to type II in Mexican Americans, a population at high risk for this disorder. Twenty-eight 474 initially nondiabetic Americans developed after 8 yr follow-up. Converters were older had higher BMIs, centrality indices, than nonconverters. Subjects the highest...
The familial aggregation of coronary heart disease can be in large part accounted for by a clustering cardiovascular risk factors. To elucidate the determinants disease, many epidemiological studies have focused on behavioral and lifestyle these factors, whereas others examined whether specific candidate genes influence quantitative variation phenotypes.Among Mexican Americans from San Antonio (Tex), we quantified relative contributions both genetic environmental influences to panel...
Telomere length (TL) is emerging as a biomarker for aging and survival. To evaluate factors influencing this trait, we measured TL in large homogeneous population, estimated the heritability (h(2)), tested parental effects on variation. Our sample included 356 men 551 women, aged 18-92 years, from Amish families. Mean leukocytes was by quantitative PCR (mean: 6,198 +/- 1,696 bp). The h(2) of 0.44 0.06 (P < 0.001), after adjusting age, sex, assay batch. As expected, negatively correlated with...
Migraine with aura is associated ischemic stroke, but few studies have investigated the clinical and anatomic features of this association. We assessed association probable migraine without visual stroke within subgroups defined by subtype, vascular territory, characteristics, other features.Using data from a population-based, case-control study, we studied 386 women ages 15 to 49 years first 614 age- ethnicity-matched controls. Based on their responses questionnaire headache symptoms,...
Hypertension places a major burden on individual and public health, but the genetic basis of this complex disorder is poorly understood. We conducted genome-wide association study systolic diastolic blood pressure (SBP DBP) in Amish subjects found strong signals with common variants serine/threonine kinase gene, STK39 . confirmed an independent 4 non-Amish Caucasian samples including Diabetes Genetics Initiative, Framingham Heart Study, GenNet, Hutterites (meta-analysis combining all...