Mark E. Bastin
A5034776089- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Neonatal and fetal brain pathology
- Dementia and Cognitive Impairment Research
- MRI in cancer diagnosis
- Cerebrovascular and Carotid Artery Diseases
- Genetic Associations and Epidemiology
- Acute Ischemic Stroke Management
- Epigenetics and DNA Methylation
- Cerebrospinal fluid and hydrocephalus
- Birth, Development, and Health
- Health, Environment, Cognitive Aging
- Alzheimer's disease research and treatments
- Bone and Joint Diseases
- Genomic variations and chromosomal abnormalities
- RNA regulation and disease
- Infant Development and Preterm Care
- Neurological Disease Mechanisms and Treatments
- Diet and metabolism studies
- Cardiovascular Health and Disease Prevention
- Neural dynamics and brain function
- Medical Image Segmentation Techniques
- Genetics and Neurodevelopmental Disorders
University of Edinburgh
2016-2025
UK Dementia Research Institute
2018-2025
NHS Lothian
2014-2024
University of Lausanne
2024
University of Oslo
2024
Sichuan University
2024
University of Hong Kong
2024
Maxwell Institute for Mathematical Sciences
2018-2023
Cohort (United Kingdom)
2023
Western General Hospital
2011-2021
Sex differences in the human brain are of interest for many reasons: example, there sex observed prevalence psychiatric disorders and some psychological traits that might help to explain. We report largest single-sample study structural functional (2750 female, 2466 male participants; mean age 61.7 years, range 44–77 years). Males had higher raw volumes, surface areas, white matter fractional anisotropy; females cortical thickness tract complexity. There was considerable distributional...
Age-associated disease and disability are placing a growing burden on society. However, ageing does not affect people uniformly. Hence, markers of the underlying biological process needed to help identify at increased risk age-associated physical cognitive impairments ultimately, death. Here, we present such biomarker, 'brain-predicted age', derived using structural neuroimaging. Brain-predicted age was calculated machine-learning analysis, trained neuroimaging data from large healthy...
Quantifying the microstructural properties of human brain's connections is necessary for understanding normal ageing and disease. Here we examine brain white matter magnetic resonance imaging (MRI) data in 3,513 generally healthy people aged 44.64-77.12 years from UK Biobank. Using conventional water diffusion measures newer, rarely studied indices neurite orientation dispersion density imaging, document large age associations with microstructure. Mean diffusivity most age-sensitive measure,...
The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium was set up to analyze brain measures and genotypes from multiple sites across the world improve power detect genetic variants that influence brain. Diffusion tensor imaging (DTI) yields quantitative sensitive development degeneration, some common may be associated with white matter integrity or connectivity. DTI measures, such as fractional anisotropy (FA) of water diffusion, useful for identifying microstructure....
Human white matter integrity has been related to information processing speed, but it is unknown whether impaired results from localized processes or a general property shared across tracts. Based on diffusion MRI scans of 132 healthy individuals with narrow age range around 72 years, the eight major tracts was quantified using probabilistic neighborhood tractography. Principal component analyses (PCAs) were conducted correlations between tracts, separately for four tract-averaged...
Abstract Aims Several factors are known to increase risk for cerebrovascular disease and dementia, but there is limited evidence on associations between multiple vascular (VRFs) detailed aspects of brain macrostructure microstructure in large community-dwelling populations across middle older age. Methods results Associations VRFs (smoking, hypertension, pulse pressure, diabetes, hypercholesterolaemia, body mass index, waist–hip ratio) structural diffusion MRI markers were examined UK...
Objectives: Strong qualitative and quantitative evidence exists of white matter abnormalities in both schizophrenia bipolar disorder (BD). Diffusion tensor imaging (DTI) studies suggest altered connectivity disorders. We aim to address the diagnostic specificity these Methods: DTI was used assess integrity clinically stable patients with familial BD (n = 42) 28), controls 38). Differences fractional anisotropy (FA) were measured using voxel‐based morphometry automated region interest...
a b s t r c White matter hyperintensities (WMH) of presumed vascular origin are common finding in brain magnetic resonance imaging older individuals and contribute to cognitive functional decline.It is unknown how WMH form, although white degeneration characterized pathologically by demyelination, axonal loss, rarefaction, often attributed ischemia.Changes within normalappearing (NAWM) subjects with have also been reported but not yet fully characterized.Here, we describe the vivo signatures...
Cerebral small vessel disease (SVD) may cause cognitive dysfunction. We tested the association between combined presence of magnetic resonance imaging (MRI) features SVD and ability in older age. Cognitive testing brain MRI were performed 680 participants. lacunes, white matter hyperintensities, microbleeds, perivascular spaces summed a score 0–4 representing all combined. also applied latent variable modeling to test whether 4 form unitary construct. The showed significant associations with...
To determine the magnitude of potentially causal relationships among vascular risk factors (VRFs), large-artery atheromatous disease (LAD), and cerebral white matter hyperintensities (WMH) in 2 prospective cohorts.
The two hemispheres of the human brain differ functionally and structurally. Despite over a century research, extent to which asymmetry is influenced by sex, handedness, age, genetic factors still controversial. Here we present largest ever analysis subcortical asymmetries, in harmonized multi-site study using meta-analysis methods. Volumetric seven structures was assessed 15,847 MRI scans from 52 datasets worldwide. There were sex differences globus pallidus putamen. Heritability estimates,...
Abstract Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66.3 ± 8.6 yr, 96.9% European ancestry) revealed 24 genome-wide significant PVS risk loci, mainly the white matter. These were associated with matter already young adults ( N = 1,748; 22.1 2.3 yr) enriched early-onset...
There is growing evidence that schizophrenia a disorder of cortical connectivity. Specifically, frontotemporal and frontoparietal connections are thought to be functionally impaired. Diffusion tensor magnetic resonance imaging (DT-MRI) technique has the potential demonstrate structural disconnectivity in schizophrenia.To investigate integrity white matter tracts schizophrenia.Thirty patients with DSM-IV thirty matched control subjects underwent DT-MRI MRI. Fractional anisotropy - an index...
Objective: To test the hypothesis that white matter integrity, as measured by diffusion tensor and magnetization transfer MRI is significantly associated with cognitive ability in youth old age. Methods: Forty, nondemented, surviving participants of Scottish Mental Survey 1932 underwent brain a battery psychometric tests covering major domains information processing efficiency. IQ scores were available from age 11. Mean diffusivity, fractional anisotropy (FA), ratio (MTR) frontal...
As the population of world ages, age-related cognitive decline is becoming an ever-increasing problem. However, changes in brain structure that accompany normal aging, and role they play decline, remain to be fully elucidated.This study aims characterize old age, investigate relationships between aging using Lothian Birth Cohort 1936. Here, we report rationale, design methodology neurovascular imaging protocol developed this cohort.An observational, longitudinal 1936, which comprises 1091...