Robin Bülow
A5027711194- Functional Brain Connectivity Studies
- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Advanced MRI Techniques and Applications
- Health, Environment, Cognitive Aging
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Genomic variations and chromosomal abnormalities
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Disease and Adiposity
- Pancreatic and Hepatic Oncology Research
- Dementia and Cognitive Impairment Research
- Nutrition and Health in Aging
- Sleep and Wakefulness Research
- Bioinformatics and Genomic Networks
- Nutritional Studies and Diet
- Congenital heart defects research
- Stress Responses and Cortisol
- Cardiac Imaging and Diagnostics
- Sleep and related disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- MRI in cancer diagnosis
- Genetics and Neurodevelopmental Disorders
Universitätsmedizin Greifswald
2016-2025
Universität Greifswald
2012-2025
German Centre for Cardiovascular Research
2019-2024
Humboldt-Universität zu Berlin
2024
German Center for Neurodegenerative Diseases
2023
European Neuroendocrine Tumor Society
2023
Universitätsklinikum Würzburg
2023
Vrije Universiteit Amsterdam
2021
Amsterdam University Medical Centers
2021
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2020
To analyse the prevalence, incidence and clinical relevance of pancreatic cysts detected as incidental finding in a population-based longitudinal study.A total 1077 participants (521 men, mean age 55.8±12.8 years) 2333 from Study Health Pomerania (SHIP) underwent magnetic resonance cholangiopancreaticography (MRCP) at baseline (2008-2012). MRCP was analysed for with diameter ≥2 mm. 676/1077 subjects received 5-year follow-up (2014-2016). The prevalence (weighted study participation) were...
<h3>Importance</h3> Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these is not well understood. <h3>Objective</h3> To determine neurobiologic correlates of between cases and controls 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum (ASD), bipolar (BD), major depressive (MDD), obsessive-compulsive (OCD), schizophrenia. <h3>Design, Setting,...
... The Study of Health in Pomerania (SHIP) comprises the two independent cohorts SHIP-START (recruited between 1997 and 2001) SHIP-TREND 2008 to 2012), which were established examine health disease status general adult population Northeast Germany given that this region had lowest life expectancy 1990s.1 initial cohort was renamed avoid confusion with designation SHIP, as whole project different cohorts. Both serve purpose understanding concepts their greatest possible complexity, rather...
The German National Cohort (NAKO) is a multidisciplinary, population-based prospective cohort study that aims to investigate the causes of widespread diseases, identify risk factors and improve early detection prevention disease. Specifically, NAKO designed novel better characterize established protection for development cardiovascular cancer, diabetes, neurodegenerative psychiatric musculoskeletal respiratory infectious diseases in random sample general population. Between 2014 2019, total...
Abstract Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66.3 ± 8.6 yr, 96.9% European ancestry) revealed 24 genome-wide significant PVS risk loci, mainly the white matter. These were associated with matter already young adults ( N = 1,748; 22.1 2.3 yr) enriched early-onset...
To detail the rationale, design, and future perspective of implementing whole-body magnetic resonance (MR) imaging in German National Cohort, a large multicentric population-based study.All institutional review boards approved study, informed consent is obtained before study enrollment. Participants are enrolled from random sample general population at five dedicated sites among 18 recruitment centers. MR facilities equipped with identical 3.0-T imager technology use uniform protocols....
Abstract Background Mortality attributable to heart failure remains high. The prevalence of in patients with diabetes mellitus ranges from 19 26%. It is estimated that up 21.1 million adults the United States have diagnosed and around 80.8 impaired fasting glucose. We investigated associations glucose (FG) insulin (FI), homeostasis model assessment-insulin resistance index (HOMA-IR) 2-h postload (2HG) (2HI) parameters left ventricular geometry function arterial stiffness determined by...
Abstract Background Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim this study was to examine whether CM severity and type are associated with MDD-related brain alterations, how they interact sex age. Methods Within ENIGMA-MDD network, subtypes using Trauma Questionnaire were assessed structural magnetic resonance imaging data from patients MDD healthy controls analyzed a mega-analysis comprising total 3872 participants aged...
<h3>Importance</h3> Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) 2 (BP2) are associated with neurodevelopmental disorders. These structural variants present 0.5% to 1.0% of population, making BP1-BP2 site most prevalent known pathogenic copy number variation (CNV). It is unknown what extent this CNV influences brain structure affects cognitive abilities. <h3>Objective</h3> To determine association deletion duplication CNVs cortical...
In the medical imaging domain, deep learning-based methods have yet to see widespread clinical adoption, in part due limited generalization performance across different devices and acquisition protocols. The deviation between estimated brain age biological is an established biomarker of health such models may benefit from increased cross-site generalizability.
Abstract Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, diagnostic predictive power of existing algorithms has been limited by small sample sizes, lack representativeness, data leakage, and/or overfitting. Here, we overcome these limitations with largest multi-site size date (N = 5365) provide a generalizable ML classification benchmark major depressive disorder (MDD) using shallow...
The absence of population-stratified cardiovascular magnetic resonance (CMR) reference ranges from large cohorts is a major shortcoming for clinical care.
Carriers of large recurrent copy number variants (CNVs) have a higher risk developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes 12 deletion duplication 6882 non-carriers from the large-scale Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent calling procedures, standardized FreeSurfer image analysis, we found negative dose-response associations with on...