Calvin Chin
A5050711774- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Advanced MRI Techniques and Applications
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Retinal Imaging and Analysis
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Obstructive Sleep Apnea Research
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Connective tissue disorders research
- Genetic Associations and Epidemiology
- Congenital heart defects research
- Coronary Interventions and Diagnostics
- Cardiovascular Effects of Exercise
- Acute Myocardial Infarction Research
- Cardiovascular Health and Disease Prevention
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Nutritional Studies and Diet
- Cardiac Fibrosis and Remodeling
- Genomics and Rare Diseases
Duke-NUS Medical School
2016-2025
National University of Singapore
2016-2025
National Heart Centre Singapore
2016-2025
SEGi University
2025
GTx (United States)
2024
University of Massachusetts Chan Medical School
2023
British Heart Foundation
2013-2023
University of Glasgow
2023
National University Heart Centre Singapore
2017-2021
University of Edinburgh
2013-2019
To describe basic nonsuicidal self-injury (NSSI) characteristics and to explore sex differences.A random sample from 8 universities were invited participate in a Web-based survey 2006-2007; 38.9% (n = 14,372) participated. Analysis assessed differences NSSI prevalence, practices, severity, perceived dependency, help-seeking; adjusted odds ratios for calculated by status.Lifetime prevalence rates averaged 15.3%. Females more likely than males self-injure because they upset (adjusted ratio...
Cardiac magnetic resonance (CMR) was used to investigate the extracellular compartment and myocardial fibrosis in patients with aortic stenosis, as well their association other measures of left ventricular decompensation mortality.Progressive drives transition from hypertrophy heart failure stenosis. Diffuse is associated volume expansion that detectable by T1 mapping, whereas late gadolinium enhancement (LGE) detects replacement fibrosis.In a prospective observational cohort study, 203...
Background— 18F-Sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) are promising novel biomarkers of disease activity in aortic stenosis. We compared 18F-NaF 18F-FDG uptake with histological characterization the valve assessed whether they predicted progression. Methods Results— Thirty patients stenosis underwent combined positron emission computed tomography using radiotracers. In 12 undergoing replacement surgery (10 for each tracer), radiotracer (mean tissue/background ratio)...
High-sensitivity cardiac troponin I (cTnI) assays hold promise in detecting the transition from hypertrophy to heart failure aortic stenosis. We sought investigate mechanism for release patients with stenosis and whether plasma cTnI concentrations are associated long-term outcome.Plasma were measured two patient cohorts using a high-sensitivity assay. First, Mechanism Cohort, 122 (median age 71, 67% male, valve area 1.0 ± 0.4 cm(2)) underwent cardiovascular magnetic resonance...
Background: Aortic valve replacement (AVR) for aortic stenosis is timed primarily on the development of symptoms, but late surgery can result in irreversible myocardial dysfunction and additional risk. The aim this study was to determine whether presence focal scar preoperatively associated with long-term mortality. Methods: In a longitudinal observational outcome study, survival analysis performed patients severe listed intervention at 6 UK cardiothoracic centers. Patients underwent...
Myocardial fibrosis is a key mechanism of left ventricular decompensation in aortic stenosis and can be quantified using cardiovascular magnetic resonance (CMR) measures such as extracellular volume fraction (ECV%). Outcomes following valve intervention may linked to the presence extent myocardial fibrosis.This study sought determine associations between ECV% markers post-intervention clinical outcomes.Patients with severe underwent CMR, including quantification modified Look-Locker...
Hypertrophic cardiomyopathy (HCM) exhibits genetic heterogeneity that is dominated by variation in eight sarcomeric genes. Genetic a large number of non-sarcomeric genes has also been implicated HCM but not formally assessed. Here we used very case and control cohorts to determine the extent which contributes HCM.We sequenced known putative new prospective cohort (n = 804) analysed data alongside largest published series clinically genotyped patients 6179), previously reference population...
Background: Aortic stenosis is accompanied by progressive left ventricular hypertrophy and fibrosis. We investigated the natural history of these processes in asymptomatic patients their potential reversal post-aortic valve replacement (AVR). Methods: Asymptomatic symptomatic with aortic underwent repeat echocardiography magnetic resonance imaging. Changes peak aortic-jet velocity, mass index, diffuse fibrosis (indexed extracellular volume), (late gadolinium enhancement [LGE]) were...
Hypertension guidelines recommend diagnosis and treatment of obstructive sleep apnea (OSA) in patients with hypertension. The mandibular advancement device (MAD) is an oral appliance therapy for who decline or cannot tolerate CPAP. We compared the relative effectiveness MAD versus CPAP reducing 24-hour ambulatory BP. In investigator-initiated, randomized, non-inferiority trial (pre-specified margin 1.5 mmHg), 321 participants, aged over 40, hypertension increased cardiovascular risk were...
Reduction in capillary density or rarefaction is a hallmark of essential hypertension. We measured the retinal using noninvasive optical coherence tomographic angiography (OCT-A) adults with treated systemic hypertension and determined possible correlations ambulatory blood pressure (BP) renal parameters.This observational cross-sectional study consisted 153 normal eyes from 77 nondiabetic hypertensive [mean (SD) age, 58 (9) years; 49% women; 23% poorly controlled BP]. Data on 24-h BP...
ECG left ventricular hypertrophy with strain is associated an adverse prognosis in aortic stenosis. We investigated the mechanisms and outcomes strain.One hundred two patients (age, 70 years [range, 63-75 years]; male, 66%; valve area, 0.9 cm(2) 0.7-1.2 cm(2)]) underwent ECG, echocardiography, cardiovascular magnetic resonance. They made up mechanism cohort. Myocardial fibrosis was determined late gadolinium enhancement (replacement fibrosis) T1 mapping (diffuse fibrosis). The relationship...
To determine the optimal T1 mapping approach to assess myocardial fibrosis at 3T.T1 was performed 3T using modified look-locker-inversion sequence in 20 healthy volunteers and patients with aortic stenosis (AS). Pre- post-contrast T1, partition coefficient (λ; ΔRmyocardium/ΔRblood, where ΔR = 1/post-contrast - 1/pre-contrast T1), extracellular volume fraction [ECV; λ (1 haematocrit)] were assessed. After establishing time point region for analysis, we compared reproducibility of these...
Asian populations are under-represented in human genomics research. Here, we characterize clinically significant genetic variation 9051 genomes representing East Asian, South and severely Austronesian-speaking Southeast ancestries. We observe disparate risk burden attributable to ancestry-specific recurrent variants identify individuals with specific ancestries discordant their self-reported ethnicity, mostly due cryptic admixture. About 27% of severe recessive disorder genes appreciable...
The prognostic significance of focal and diffuse myocardial fibrosis in patients with cardiovascular risk factors is unclear.REMODEL (Response the Myocardium to Hypertrophic Conditions Adult Population) an observational cohort asymptomatic essential hypertension. All participants underwent magnetic resonance assess for fibrosis: nonischemic late gadolinium enhancement (LGE), native T1, postcontrast extracellular volume fraction including/excluding LGE regions, interstitial (extracellular...
Sodium-glucose cotransporter 2 inhibitors are believed to improve cardiac outcomes due their osmotic diuretic potential. The goal of this study was test the hypothesis that vasopressin-driven urine concentration overrides effect glucosuria induced by dapagliflozin treatment. DAPA-Shuttle1 (Hepato-renal Regulation Water Conservation in Heart Failure Patients With SGLT-2 Inhibitor Treatment) a single-center, double-blind, randomized, placebo-controlled trial, which patients with chronic heart...
The absence of population-stratified cardiovascular magnetic resonance (CMR) reference ranges from large cohorts is a major shortcoming for clinical care.