A5073765015- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Cardiac Health and Mental Health
- Liver Disease Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- Cardiac tumors and thrombi
- Health Systems, Economic Evaluations, Quality of Life
- Lipoproteins and Cardiovascular Health
- Frailty in Older Adults
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac Valve Diseases and Treatments
- Diabetes Treatment and Management
- Nutrition and Health in Aging
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Diet, Metabolism, and Disease
- Pharmacology and Obesity Treatment
National University of Singapore
2016-2025
National University Heart Centre Singapore
2016-2025
National University Health System
2016-2025
National Taiwan University
2025
National Taiwan University Hospital
2025
Guangdong Pharmaceutical University
2025
Amsterdam University Medical Centers
2025
National University Hospital
2015-2024
National Heart Centre Singapore
2013-2024
Tan Tock Seng Hospital
2014-2024
Abstract East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y12 receptor inhibitors (e.g., ticagrelor prasugrel) direct oral anticoagulants are commonly used in current daily practice, the unique risk–benefit trade-off Asians has been a topic of emerging interest. In this article, we propose updated evidence future directions treatment
There is a paucity of data from large cohort studies examining the prognostic significance obstructive sleep apnea (OSA) in patients with coronary artery disease. We hypothesized that OSA predicts subsequent major adverse cardiac and cerebrovascular events (MACCEs) undergoing percutaneous intervention.The Sleep Stent Study was prospective, multicenter registry successfully treated intervention 5 countries. Between December 2011 April 2014, 1748 eligible were prospectively enrolled. The 1311...
Abstract Aims The prediction of future trends in cardiovascular disease (CVD) mortality and their risk factors can assist policy-makers healthcare planning. This study aims to project geospatial CVDs underlying from 2025 2050. Methods results Using historical data on disability-adjusted life years (DALYs) the Global Burden Disease (GBD) 2019 study, encompassing period 1990 2019, Poisson regression was performed model DALYs associated with CVD its Subgroup analysis based GBD super-regions....
Hypertension guidelines recommend diagnosis and treatment of obstructive sleep apnea (OSA) in patients with hypertension. The mandibular advancement device (MAD) is an oral appliance therapy for who decline or cannot tolerate CPAP. We compared the relative effectiveness MAD versus CPAP reducing 24-hour ambulatory BP. In investigator-initiated, randomized, non-inferiority trial (pre-specified margin 1.5 mmHg), 321 participants, aged over 40, hypertension increased cardiovascular risk were...
Background The upper reference limit of normal (ULN) cardiac troponin (cTn) for older adults can be higher than young adults, while the same ULN is used both and in current clinical practice. Methods In this multicentre longitudinal cohort study, non-acute myocardial infarction (non-AMI) inpatients with at least two cTn concentrations hospitalised between 2013 2022 Tianjin Health Medical Data Platform were included. Multivariable Cox proportional hazards landmark regression models to...
A large number of information security breaches in the workplace result from employees' failure to comply with organizational guidelines. Recent surveys report that 78% computer attacks appear form viruses embedded email attachments. Employees who open e-mail attachments unknown sources risk infecting their own computers as well other sharing same network. Therefore, more attention needs be paid learning why non-compliant behavior takes place so appropriate measures for curbing occurrence...
There are limited contemporary data comparing long-term outcomes after cardiac catheterization for ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI).We studied patients undergoing STEMI (n=2413) NSTEMI (n=1974) between 1999 2005 with at least 1 significant coronary lesion > or =75%. We compared adjusted mortality rates over restricted time intervals the differential impact of early revascularization on stratified by ST-elevation status. Between 2007, 1274 died, a...
We sought to determine the effect of severe obstructive sleep apnea (OSA) on long-term outcomes after myocardial infarction. hypothesized that OSA was associated with lower event-free survival rate ST-segment elevation infarction (STEMI).A total 120 patients underwent an overnight study during index admission for STEMI. Severe defined as hypopnea (AHI) ≥ 30, and non-severe AHI < 30.Among 105 who completed study, 44 (42%) had 61 (58%) OSA. The median creatine kinase level mean left...
We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among undergoing coronary artery bypass surgery, those recent AMI, compared without showed significant increase 5 the signature's 12 but not simultaneously-biopsied aortic tissue. In contrast, rat AMI model, sham control, concentrations all up-regulation 3 ceramide-producing enzymes, suggesting ischemic...