A5033649095- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac Health and Mental Health
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Obstructive Sleep Apnea Research
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Vascular Procedures and Complications
- Lipoproteins and Cardiovascular Health
- Angiogenesis and VEGF in Cancer
- Peripheral Artery Disease Management
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Mechanical Circulatory Support Devices
- Atrial Fibrillation Management and Outcomes
- Infective Endocarditis Diagnosis and Management
- Coronary Artery Anomalies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac and Coronary Surgery Techniques
China-Japan Friendship Hospital
2025
National University Heart Centre Singapore
2016-2025
National University of Singapore
2014-2024
National University Health System
2013-2024
Singapore Heart Foundation
2024
National University Hospital
2007-2022
Society of Interventional Radiology
2022
Ng Teng Fong General Hospital
2022
King George's Medical University
2016
Tan Tock Seng Hospital
2006-2016
There is a paucity of data from large cohort studies examining the prognostic significance obstructive sleep apnea (OSA) in patients with coronary artery disease. We hypothesized that OSA predicts subsequent major adverse cardiac and cerebrovascular events (MACCEs) undergoing percutaneous intervention.The Sleep Stent Study was prospective, multicenter registry successfully treated intervention 5 countries. Between December 2011 April 2014, 1748 eligible were prospectively enrolled. The 1311...
We sought to determine the effect of severe obstructive sleep apnea (OSA) on long-term outcomes after myocardial infarction. hypothesized that OSA was associated with lower event-free survival rate ST-segment elevation infarction (STEMI).A total 120 patients underwent an overnight study during index admission for STEMI. Severe defined as hypopnea (AHI) ≥ 30, and non-severe AHI < 30.Among 105 who completed study, 44 (42%) had 61 (58%) OSA. The median creatine kinase level mean left...
Given the rapidly growing burden of cardiovascular disease (CVD) in Asia, this study forecasts CVD and associated risk factors Asia from 2025 to 2050.
ABSTRACT Background Classical crush has a lower rate of final kissing balloon inflation (FKBI) immediately after percutaneous coronary intervention (PCI). The double (DK) technique the potential to increase FKBI rate, and no prospective studies on comparison classical with DK techniques have been reported. Materials methods Three hundred eleven patients true bifurcation lesions were randomly divided into ( n = 156) 155) groups. Clinical angiographic details at follow‐up 8 months indexed....
Little is known about the effect of coronavirus disease 2019 (COVID-19) pandemic and outbreak response measures on door-to-balloon time (D2B). This study examined both D2B clinical outcomes patients with STEMI undergoing primary percutaneous coronary intervention (PPCI).
Abstract Background Stress-induced hyperglycaemia at time of hospital admission has been linked to worse prognosis following acute myocardial infarction (AMI). In addition glucose, other glucose-related indices, such as HbA1c, glucose-HbA1c ratio (GHR), and stress-hyperglycaemia (SHR) are potential predictors clinical outcomes AMI. However, the optimal blood GHR, SHR cut-off values for predicting adverse post-AMI unknown. As such, we determined 1-year all cause mortality in diabetic...
An increasing proportion of patients with acute myocardial infarction (AMI) are presenting without standard modifiable risk factors (SMuRFs) hypertension, hypercholesterolemia, diabetes, and smoking, but an unexpectedly increased mortality. This study examined the SMuRF-less AMI in a multiethnic Asian population.We recruited from 2011 to 2021 compared prevalence, clinical characteristics, outcomes SMuRF patients. Multivariable analysis was used compare 30-day cardiovascular mortality,...
Understanding the trajectories of metabolic risk factors for acute myocardial infarction (AMI) is necessary healthcare policymaking. We estimated future projections incidence diseases in a multi-ethnic population with AMI.The and mortality contributed by AMI (diabetes mellitus [T2DM], hypertension, hyperlipidemia, overweight/obesity, active/previous smokers) were projected up to year 2050, using linear Poisson regression models based on Singapore Myocardial Infarction Registry from 2007...
Abstract Aim Patients with metabolic dysfunction‐associated steatotic liver disease (MASLD) are at increased risk of incident cardiovascular disease. However, the clinical characteristics and prognostic importance MASLD in patients presenting acute myocardial infarction (AMI) have yet to be examined. Methods This study compared outcomes without AMI a tertiary centre Singapore. was defined as hepatic steatosis, least one five criteria. Hepatic steatosis determined using Steatosis Index....
We aim to examine the risk predictors of contrast-induced nephropathy (CIN) in patients with normal baseline serum creatinine (Cr). CIN is an important complication postpercutaneous coronary intervention (PCI). Previous studies examined chronic renal impairment. No large investigated function which constitute majority undergoing PCI. identify this cohort and clinical outcomes.A total 3036 Cr (<1.5 mg/dL) who did not receive prophylaxis while PCI were enrolled. occurrence mortality outcome at...
Recent studies have demonstrated favourable clinical outcomes for the everolimus-eluting bioresorbable vascular scaffold (BVS) ABSORB™ in patients with stable coronary artery disease. There are currently no data on its use ST-segment elevation myocardial infarction (STEMI). We assessed safety and impact of BVS setting primary percutaneous intervention (PCI) presenting STEMI to our institution.A total 11 who underwent PCI intent implantation between October 2012 April 2013 at institution were...
Objectives There are conflicting data on the relationship between time of symptom onset during 24-hour cycle (circadian dependence) and infarct size in ST-elevation myocardial infarction (STEMI). Moreover, impact this circadian pattern clinical outcomes is unknown. We sought to study dependence its STEMI. Methods studied 6,710 consecutive patients hospitalized for STEMI from 2006 2009 a tropical climate with non-varying day-night cycles. categorized into four 6-hour intervals: midnight–6:00...
Abstract Smoking is one of the leading risk factors for cardiovascular diseases, including ischemic heart disease and hypertension. However, in acute myocardial infarction (AMI) patients, smoking has been associated with better clinical outcomes, a phenomenon termed “smoker’s paradox.” Given known detrimental effects on system, it proposed that beneficial effect outcomes due to age differences between smokers non-smokers therefore smoker’s pseudoparadox. The aim this study was evaluate...
Aim, materials & methods: We investigated the functional significance of CYP2C19*2, *3, *17 and PON1 Q192R SNPs in 89 consecutive Asian patients on clopidogrel treatment prevalence functionally significant polymorphisms among 300 Chinese, Malays Indians. Results: Both CYP2C19 loss-of-function alleles (*2 or *3) were associated with higher platelet reactivity while gain-of-function allele (*17) had lower reactivity. For PON1, median PRI was not significantly different between QQ, QR RR...
Background In 2020 the largest number of patients with coronary artery disease (CAD) will be found in Asia. Published epidemiological and clinical reports are overwhelmingly derived from western (White) cohorts data Asia scant. We compared CAD severity all-cause mortality among 4 world's most populous ethnicities: Whites, Chinese, Indians Malays. Methods The UNIted CORoNary cohort (UNICORN) simultaneously enrolled parallel populations consecutive undergoing angiography or intervention for...