A5101981220- Tuberculosis Research and Epidemiology
- Statistical Methods in Clinical Trials
- Mycobacterium research and diagnosis
- Statistical Distribution Estimation and Applications
- Cleft Lip and Palate Research
- Cardiac Arrest and Resuscitation
- Corneal surgery and disorders
- Optimal Experimental Design Methods
- Craniofacial Disorders and Treatments
- Ophthalmology and Visual Impairment Studies
- Statistical Methods and Inference
- Glaucoma and retinal disorders
- Statistical Methods and Bayesian Inference
- Airway Management and Intubation Techniques
- Respiratory Support and Mechanisms
- Stroke Rehabilitation and Recovery
- Healthcare and Venom Research
- Acute Kidney Injury Research
- Traditional Chinese Medicine Studies
- Bayesian Methods and Mixture Models
- Diagnosis and treatment of tuberculosis
- Antibiotics Pharmacokinetics and Efficacy
- Acupuncture Treatment Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Gene expression and cancer classification
Singapore Clinical Research Institute
2015-2024
Duke-NUS Medical School
2014-2021
University of Leicester
2019
KK Women's and Children's Hospital
2019
SingHealth Duke-NUS Academic Medical Centre
2019
Singapore General Hospital
2019
National University of Singapore
2015
University of Science and Technology of China
2006-2010
Tuberculosis is usually treated with a 6-month rifampin-based regimen. Whether strategy involving shorter initial treatment may lead to similar outcomes unclear.
A novel, fully bacterially produced recombinant virus-like particle (VLP) based influenza vaccine (gH1-Qbeta) against A/California/07/2009(H1N1) was tested in a double-blind, randomized phase I clinical trial at two sites Singapore. The evaluated the immunogenicity and safety of gH1-Qbeta presence or absence alhydrogel adjuvant. Healthy adult volunteers with no low pre-existing immunity A/California/07/2009 (H1N1) were to receive intramuscular injections 21 days apart, 100μg vaccine,...
<b><i>Background:</i></b> Healthy gut microflora is essential for oral tolerance and immunity. A promising approach to preventing allergic diseases in genetically at-risk infants introduce administration of probiotics early life when their immune system still relatively immature. <b><i>Objective:</i></b> In this follow-up study, we aim determine if early-life supplementation with strains has any long-term effect on outcomes....
Studies have suggested that selective microbial targets prevail in the fecal microbiota of infants with eczema. This study evaluated composition who developed eczema first 5 years life and compared these those healthy controls. Children 2 years, at age controls were selected from placebo arm a birth cohort at-risk participating randomized double-blind trial on protective effects supplemental probiotics early allergic outcomes. Molecular evaluation conducted using Fluorescence In Situ...
Summary In this study, we aimed to evaluate the bacterial contamination of surgical scrub suits worn outside operating theatre. We randomised 16 anaesthetists on separate occasions into one 3 groups: restricted theatre only; and wards; departmental office. For each group, sample fabric pieces attached chest, waist hip areas suit were removed at 150 min intervals between 08:30 16:00 day sent for microbiological assessment. Mean counts increased significantly over course working (p = 0.036),...
In the pharmaceutical industry, it is desirable to apply an adaptive seamless trial design combine two separate clinical studies that are normally conducted for achieving objectives such as a Phase II study dose finding and III confirmatory efficacy. As result, II/III consisting of phases, namely learning phase phase, commonly considered in development. some cases, however, endpoints may be different due long treatment duration. this case, test statistics final analysis based on combined...
Abstract COX-2 inhibition may be of benefit in the treatment tuberculosis (TB) through a number pathways including efflux pump (increasing intracellular TB drug levels) and diverse effects on inflammation immune response. We investigated celecoxib (a inhibitor) alone with standard anti-tuberculosis drugs whole-blood bactericidal activity (WBA) model. Healthy volunteers took single dose (400 mg), followed (after 1 week) by either rifampicin (10 mg/kg) or pyrazinamide (25 mg/kg), 2 7 days...
Faropenem has in vitro activity against Mycobacterium tuberculosis (Mtb) and shows synergy with rifampicin. We tested this a whole-blood bactericidal (WBA) trial.We randomized healthy volunteers to receive single oral dose of faropenem (600 mg) amoxicillin/clavulanic acid (500/125 ( n = 8), rifampicin (10 mg/kg) 14) or the combination + 14). Blood was drawn at intervals 8 h post-dose. Drug levels were measured using LC-tandem MS. WBA by inoculating blood samples Mtb estimating change...
Evidence regarding the efficacy of high-flow nasal cannula (HFNC) oxygenation for preoxygenation and apnoeic is conflicting. Our objective to evaluate whether HFNC maintains higher oxygen saturation (SpO2) during rapid sequence intubation (RSI) in ED patients compared usual care.This was a multicentre, open-label, randomised controlled trial adult requiring RSI. Patients were randomly assigned 1:1 either intervention (HFNC at 60L/min) group or control (non-rebreather mask prongs least...
Abstract Background Interleukin 4 (IL-4), increased in tuberculosis infection, may impair bacterial killing. Blocking IL-4 confers benefit animal models. We evaluated safety and efficacy of pascolizumab (humanized anti–IL-4 monoclonal antibody) as adjunctive treatment. Methods Participants with rifampicin-susceptible pulmonary received a single intravenous infusion or placebo, standard 6-month Pascolizumab dose successive cohorts: (1) nonrandomized 0.05 mg/kg (n = 4); (2) 0.5 (3) randomized...
The statistical quality control process on raw materials and/or the final product of traditional Chinese medicine (TCM) is examined. We develop a (QC) method to assess proposed consistency index from different sources products manufactured at sites. idea construct 95% confidence interval for under sampling plan. If constructed lower limit greater than prespecified QC limit, then we claim that material or have passed and hence can be released further processing use; otherwise, should...
ABSTRACT Coadministering pyrazinamide (PZA) with the xanthine oxidase inhibitor allopurinol increases systemic levels of active metabolite, pyrazinoic acid (POA), but effects on bactericidal activity against tuberculosis are unknown. We randomized healthy volunteers to take a single dose PZA (either 10 or 25 mg/kg body weight) at first visit and same 7 days later, coadministered (100 mg daily; 2 before 1 day after dose). Blood was drawn intervals until 48 h each dose, drug were measured...
Maintaining adequate oxygenation during rapid sequence intubation (RSI) is imperative to prevent peri-intubation adverse events that can lead increased duration of hospital and intensive care unit stay, or a prolonged vegetative state requiring long-term institutionalisation. Despite employing current best practices RSI, desaturation still occurs. High-flow nasal cannula (HFNC) may potentially improve pre- apnoeic allow longer safe time for RSI. We aim test the hypothesis use humidified...
Abstract Let X 1, 2,…, n be independent exponential random variables with i having failure rate λ for = 1,…, n. Denote by D i:n − i−1:n the ith spacing of order statistics 1:n ≤ 2:n ··· n:n , n, where 0:n ≡ 0. It is shown that if n+1 [≥] k then lr n+1:n+1 and 2:n+1 [D ], + j ≥ all distinct i,j, n−1:n n:n+1 denotes likelihood ratio order. We also prove 2 2:3 3:3 's. Keywords: Exponential distributionsLikelihood orderOrder statisticsPermanentSpacingsMathematics Subject Classification:...
<b><i>Background:</i></b> Most comparative clinical trials are designed to assess the treatment effect for efficacy endpoints, with less emphasis on analysis of safety outcomes. However, an extensive data could demonstrate beneficial results in terms effectiveness by reducing serious adverse events (SAEs), and their unfavourable impact study population. We aimed conduct exploratory CHInese Medicine Neuroaid Efficacy Stroke recovery (CHIMES) database comparing...
Background: The number of potential regimens drug treatment for TB is vast, meaning that evaluating each new against a control in separate two-arm trials requires huge amount resources. There is, therefore, need innovative trial designs can evaluate simultaneously. Methods & Materials: TRUNCATE-TB (two-month using novel combinations to augment effectiveness drug-sensitive tuberculosis) randomised, open-label, multi-arm, multi-stage (MAMS), parallel group strategy trial. MAMS design has been...