Background: Adherence to treatment guidelines and bacteriological conversion are the main indicators of successful drug-resistant tuberculosis patients. Evaluation health-related quality life (HRQoL) effect on HRQoL often ignored. assessment is an interesting outcome evaluate improve. Drug-resistant patients suffer not only from disease but also effects treatment. Method: This study used a cross-sectional design determine correlation body mass index (BMI), sputum status, adverse drug events...

Exercise training is key to the comprehensive management of patients with chronic obstructive pulmonary disease (COPD). Interactive game-based systems have been proposed improve effectiveness and compliance exercise training.To evaluate Wii Fit balance board as an additional tool for in COPD. As a secondary aim we will costs.In randomized controlled trial, were divided into experimental (EG) control (CG) groups. The CG performed on cycle ergometer three times week 6 weeks. EG also followed...

<p class="AbstractNormal"><em>Background: Detection of fast acid bacteria (FAB) using smear microscopy is used as a primary screening for tuberculosis diagnosis. Previous studies have shown that fluorochrome </em>(<em>Auroamine-rhodamine</em>) <em>staining showed better sensitivity compared to Ziehl-Neelsen (ZN) method in the detection FAB sputum. However this has not been recommended routine use including Indonesia. This study aimed evaluate and...

Introduction: COVID-19 emerged as a pandemic about 2 years ago. Severe and critical has been associated with increased interleukin 6 (IL-6) level neutrophil–lymphocyte ratio (NLR). This study aimed to test whether IL-6 and/or NLR are mortality. Methods: Subjects were patients suspected Omicron variant infection that hospitalized at Dr. Moewardi Hospital from October 2021 March 2022. According their medical records, subjects divided into survivor non-survivor groups. Serum of admission...

Multidrug resistance tuberculosis (MDR-TB) is a continuing threat because the treatment rather toxic. One of causes poor outcome due to adverse events, especially occurrence psychiatric events.The two cases presented in this paper are MDR-TB patients with events related depression spectrum. The diagnosis was done by psychiatrist referral hospital.The and event carried out simultaneously. able manage but other not. management need be performed carefully. Social support family friends received...

Acute exacerbation chronic obstructive pulmonary disease (AECOPD) is associated with significant poor survival. Mesenchymal stem cells (MSC) therapy has been a promising treatment for COPD; therefore, it the potential to be an additional AECOPD. Its its secretome since anti-inflammatory and immunomodulator activities. The aim of this study was determine effect as adjuvant in reducing levels interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), procalcitonin, length stay AECOPD patients. A...

Background: Pneumonia is a major health problem in all age groups and often related with sepsis. In 2021, Surviving Sepsis Campaign Guidelines mentioned several clinical scoring systems to identify patients potentials of developing sepsis, such as systemic inflammatory response syndrome (SIRS), national early warning score (NEWS), quick sequential organ failure assessment (qSOFA) (SOFA). The guideline stated that there no gold standard for diagnosing contradicting Sepsis-3 Guideline 2016...

Background: Acute lung parenchymal infection, known as pneumonia, can be carried on by multiple microorganisms, including bacteria, viruses, fungi, and parasites. Globally, community-acquired pneumonia is a major factor of morbidity, mortality, health issues. Malondialdehyde (MDA) marker oxidative stress in patients, interleukin 6 (IL-6) inflammatory process. Effect Omega-3 an immunomodulator, anti-inflammatory, antioxidant may implemented adjunctive therapy patient with pneumonia.Methods:...

Background: Inflammatory cells play an essential role in the neoplastic process by stimulating cancer proliferation, survival, and migration. Neutrophil-lymphocyte platelet-lymphocyte levels can be used as inflammatory tissue damage markers patients.Objective: This study aimed to analyze increase of neutrophil-lymphocyte ratio (NLR) platelet–lymphocyte (PLR) predictive factors for lung malignancy.Methods: was a diagnostic cross-sectional design tumor patients at Dr. Moewardi Hospital...

Background: COVID-19 reinfection has been found, although the data is not clear yet. Pandemic conditions bring about limited facilities and infrastructure, so biomarkers are an option. Research on use of ACE inhibitor drugs in patients widely conducted Indonesia.Methods: This was a retrospective cohort study that used medical record confirmed treated at dr. Moewardi General Hospital for period January to March 2022. Surviving were observed reinfections until November 2022.Results: involved...

Introduction: Chronic obstructive pulmonary disease (COPD) is the leading cause of morbidity and mortality worldwide. Cigarette smoke noxious agent result in oxidative stress activate release inflammatory mediators such as Interleukin-8 (IL-8). Quercetin a flavonoid compound containing anti-inflammatory effects which can be used an adjuvant therapy stable COPD.
 Objective: To analyze effect quercetin on serum IL-8 levels, % VEP1, CAT score COPD patients.
 Methods: Experimental...

Background: Chronic inflammation in chronic obstructive pulmonary disease (COPD) causes respiratory muscle dysfunction and decreased capacity. Incongruity of the capacity burden results increased symptoms breathlessness, inspiratory capacity, exercise quality life. The objectives study were to analyze effect harmonica as a rehabilitation modality on shortness breath symptoms, life stable COPD patient.
 Methods: Clinical trials with pre post test group design performed 30 patients at...

<b>Introduction:</b> Tuberculosis left many respiratory symptoms even when stated cure, it is not well known whether pulmonary rehabilitation plays role in improving symptoms, lung function and quality of life sequelae tuberculosis. <b>Aims:</b> To analyze effect incentive spirometry pursed lips breathing on inspiratory capacity (IC), shortness breath exercise capacity, (QoL) <b>Method:</b> A pre post test group design study was performed 32 tuberculosis patients from January-April 2018 by...

Pendahuluan: Covid-19 pertama kali dilaporkan pada bulan desember tahun 2019 lalu Maret 2020 WHO mendeklarasikan bahwa adalah pandemi global. Dari hasil penelitian didapatkan manifestasi klinis penyakit ini dapat diperparah oleh beberapa faktor dan salah satunya komorbid. Terdapat komorbid yang mempengaruhi Covid-19, diabetes melitus, melitus sendiri merupakan banyak dijumpai, terdapat sekitar 500 juta orang di dunia yag mengidap ini, karena itu diharapkan memberikan bukti empiris terkait...

Background: Pneumonia is an acute inflammation of the lung parenchyma caused by microorganisms (bacteria, viruses, fungi, parasites) and causes high morbidity mortality. Ginsenoside in ginseng have anti-inflammatory effects, potentially as adjunctive therapy community-acquired pneumonia (CAP) patients. As much 43% patients at dr. Moewardi Hospital 2016 were hospitalized passed away. The aim this study was to determine effect extract on levels procalcitonin, neutrophils, length stay Method:...

Background: Intensity for aerobic exercise is unclear in patient with COPD. Previous systematic review comparing effects of different levels training intensity was done 2011 and did not reach any conclusion. We conducted this to see the differences on various aspects health COPD patients updated information. Method: included RCTs, between groups. The primary search through Pubmed, Scopus, Science Direct, Proquest, PEdro. PEdro scale Risk Bias 2 tool used rate studies. Lastly, we also...

Background: Global TB Report 2020 states that 78% of tuberculosis patients experience drug resistancy with a global treatment success rate 57%. Drug resistance (DR TB) whom side effects such as arthralgia and hyperuricemia inadequate will affect the result.Methods: Retrospective cohort study to DR who underwent from January 2015 August at RSUD dr. Moewardi Surakarta. Survival analysis using Kaplan Meier method Cox regression test for effect risk factors on safety survival RO patients....

Background: Prior vaccination can prevent a COVID-19 patient from falling into moderate, severe, and critical conditions. The effect of on patients’ recovery has been widely studied. However, its correlation in critically severe patients with comorbidity not fully understood yet. This study aims to determine the hypertension and/or Diabetes Mellitus (DM).Methods: A retrospective cohort was conducted DM treated Dr. Moewardi Hospital, Surakarta, Indonesia March 2021 September 2021. data were...

Antiviral, anti-inflammatory, and supportive therapy are required in the Covid-19 management, whilst there is no available specific antiviral for patients. Zingiber officinale Propolis were reported to suppress pro-inflammatory cytokines their safety profiles considered several toxicity studies. However, efficacy hospitalized patients has not been clarified yet. This study explored activity of Z. modulating clinical signs hematology parameters A total 22 subjects divided into a control group...

Penyakit Paru Obstruktif Kronik (PPOK) masih menjadi masalah kesehatan nasional dan global. Pada tahun 2018, kasus PPOK di Jawa Tengah menempati urutan ke tujuh. ditandai dengan adanya obstruksi saluran napas yang berujung pada sesak napas. ini dapat menyebabkan perburukan kondisi mempengaruhi kualitas hidup. Tujuan penelitian adalah untuk mengetahui hubungan derajat tingkat hidup pasien RS UNS. Metode digunakan metode observasional analitik rancangan cross sectional. Subjek dalam Pasien...

Background: Bronchoscopy is a minimally invasive procedure used for diagnostic examination and intervention of the airways. Patient comfort cooperation during bronchoscopy are very important because they affect success outcome. The sympathetic anticholinergic effect ipratropium bromide can improve tolerance airway visualization. This study was conducted to analyze inhaled as premedication assessment dyspnea, cough, tracheobronchial secretion.Methods: clinical with quasi-experimental...

Background: In a number of cases viral infection, convalescent plasma therapy has been effective. Reportedly, the use as for COVID-19 patients with severe and life-threatening disorders is beneficial at this time. This study aims to assess effectiveness safety transfusions in hospitalized patients. Subjects Method: was clinical trial employing non-randomized comparative study. A historical control group (21 samples) selected consecutively from between May 6th, 2020, 2021 Dr. Moewardi General...

Background: COVID-19 reinfection has been identified and is being studied. Several risk factors, including a health worker having A blood type, are linked to reinfection, comorbidities such as hypertension, obesity, diabetes, asthma influence the disease's severity. To identify mutational variations associated with viral virulence spread, genetic studies required. The purpose of this study determine prevalence SARS-CoV-2 well patient characteristics factors related reinfection. Subjects...