N-acetylcysteine has antioxidant and anti-inflammatory activities that could potentially improve the clinical outcomes of coronavirus disease 2019 (COVID-19) patients. inhibits NLRP3 (NOD-, LRR- pyrin domain-containing protein 3) inflammasome results in control oxidative stress cytokine release COVID-19 The aim this study was to assess effect reducing neutrophil-lymphocyte ratio (NLR) A randomized controlled trial conducted among severe moderate treatment group received oral 1200 mg daily...

Background: Lung cancer reduces lung function, muscle mass, and psychological well-being, which lowers exercise capacity quality of life. Pulmonary rehabilitation, such as aerobic exercise, can improve the life (QoL) in patients. This study aimed to investigate influence on six-minute walking test (6MWT) Methods: A clinical trial with a quasi-experimental, pretest, post-test design was conducted stage ≥IVa adenocarcinoma patients who were receiving outpatient targeted therapy at pulmonary...

Background: Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of mortality worldwide. Acute Exacerbations COPD (AECOPD) significantly impact patient outcomes and healthcare costs. Thyroid hormone dysregulation has been proposed as potential systemic effect AECOPD. However, the relationship between thyroid hormones AECOPD clinical predictors, such %FEV1, exacerbation severity, hospitalization duration, remains unclear.Objective: This study aimed to investigate key predictors in...

Diabetes Mellitus adalah penyakit kronik yang disebabkan oleh faktor genetik, karena kesalahan pola makan, atau gaya hidup tidak sehat. Diet dan Self management menjadi poin penting pada tata laksana DM tipe 2. Persadia (Perhimpunan Indonesia) perkumpulan pasien keluarga penderita diabetes di Indonesia bertujuan untuk edukasi meningkatkan kualitas mencegah komplikasi diabetes. Analisis situasi sebelumnya menunjukkan anggota persadia cabang Surakarta mempunyai keterbatasan dalam pengetahuan...

Background: In the current COVID-19 pandemic, number of hospital visits was significantly decreased.There a decrease in outpatient from 9911 patients January to 5586 May 2020 UNS hospital.This study aims know association level stress, service quality, and fear COVID 19 with at Hospital.Research methods: The conducted Hospital July using questionnaire method.Research tools quality questionnaire, stress for scale.The patient group divided into two, on-time group, which always met schedule...

Abstract COVID-19 increases vulnerability for populations living in regions significantly impacted by the adverse effects of climate change. There is currently no definitive treatment COVID-19. Colchicine a drug that can reduce severity inhibiting NLRP3 inflammasome. This study aims to determine effect colchicine administration on high-sensitivity C-reactive protein (HsCRP) and Neutrophil Lymphocyte Ratio (NLR) levels patients. was conducted at UNS Hospital February-March 2021. The inclusion...

Background: Coronavirus disease 2019 (COVID-19) has emerged as a global health catastrophe since its first reported cases in late December 2019. Critically ill COVID-19 patients have been related to cytokine storms leading acute respiratory distress syndrome and high mortality rates. Therapeutic plasma exchange (TPE) convalescent (CP) therapy improve clinically by removing inflammatory cytokines excess using passive antibody-containing blood, respectively. This study aimed evaluate TPE CP...

Background: Cytokine plays a pivotal role in the pathogenesis of coronavirus disease 2019 (COVID-19). storm is characterized by rapid elevation an inflammatory circulating cytokine such as interleukin-6 (IL-6) and IL-1. However, according to evidence, genetic variables may affect development course infectious diseases. Multiple polymorphisms, mostly single-nucleotide polymorphisms (SNPs), have been linked this setting's predisposition viral infections. This study aimed determine frequency...

Background: Comorbid COVID-19 patients have worse outcomes or even death and a longer length of stay than without comorbidities. The purpose the study was to determine relationship between comorbidities mortality rates in at UNS Surakarta Hospital. Methods: An analytical observational with cross sectional approach, conducted January-June 2021 Sukoharjo subjects this were patients, who treated Sampling carried out by purposive sampling obtained sample 132 people consisting 66 Data collection...

COVID-19 merupakan masalah Kesehatan global yang melanda berbagai lini kehidupan masyarakat. Transmisi penularan COVID 19 pada tenaga kesehatan menjadi isu penting di era pandemi ini. Pada bulan Juli 2020, terjadi RS UNS dalam jumlah besar. Mitra pengabdian adalah PPNI (Persatuan Perawat Nasional Indonesia) UNS. Salah satu misi keselamatan kerja perawat COVID-19. Analisis menunjukkan bahwa kurang waspada terhadap sesama perawat, kurangnya pengetahuan tentang dan alat pelindung diri baik,...

Acute exacerbation chronic obstructive pulmonary disease (AECOPD) is associated with significant poor survival. Mesenchymal stem cells (MSC) therapy has been a promising treatment for COPD; therefore, it the potential to be an additional AECOPD. Its its secretome since anti-inflammatory and immunomodulator activities. The aim of this study was determine effect as adjuvant in reducing levels interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), procalcitonin, length stay AECOPD patients. A...

Coronavirus disease 2019 (COVID-19) causes severe acute respiratory in humans and has spread rapidly worldwide since its first identification December 2019. The neutrophil-to-lymphocyte ratio (NLR) describes the balance between severity of inflammation immune system to be used as an important systemic inflammatory marker. Rapid progression clinical deterioration is characterized by symptoms related high levels pro-inflammatory cytokines, like interleukin-6 (IL-6), indicating that occurrence...

N-acetylcysteine has antioxidant and anti-inflammatory activities that could potentially improve the clinical outcomes of coronavirus disease 2019 (COVID-19) patients. inhibits NLRP3 (NOD-, LRR- pyrin domain-containing protein 3) inflammasome results in control oxidative stress cytokine release COVID-19 The aim this study was to assess effect reducing neutrophil-lymphocyte ratio (NLR) A randomized controlled trial conducted among severe moderate treatment group received oral 1200 mg daily...

Introduction: Community-acquired pneumonia (CAP) can deteriorate into respiratory failure requiring immediate ventilatory intervention. This study compared the performance of PaO2/FiO2 (P/F) ratio, ratio oxygen saturation (ROX) index, and heart rate, acidosis, consciousness, oxygenation, rate (HACOR) score in predicting non-invasive ventilation (NIV) length hospital stay patients diagnosed with CAP. Methods: was conducted at Universitas Sebelas Maret Hospital, Surakarta, from March to...

Leptospirosis is an uncommon infectious illness – a spirochetal zoonosis caused by Leptospira species and the primary cause of human leptospirosis exposure to urine infected rodents. Clinical manifestations are diverse, ranging from asymptomatic infection severe life-threatening with multiorgan dysfunction. The condition known as Weil's disease, which characterized feverish jaundice, acute kidney damage, bleeding. aim this case report was present disease occurred simultaneously...

Background: Community-acquired pneumonia (CAP) is a respiratory infectious disease caused by bacteria, viruses, or fungi. Procalcitonin (PCT) levels will rise, especially in bacterial infection. PCT examination CAP can help to confirm the diagnosis and anticipate complications. diagnosed symptoms, vital signs, laboratory tests, radiographic investigations. Inflammatory biomarkers are required for predicting causative microorganisms, guiding antibiotic therapy, determining severity. The...

Background: Chronic obstructive pulmonary disease (COPD) is the leading cause of morbidity and mortality worldwide. Exposure to cigarette smoke activates alveolar macrophages producing neutrophils proteases such as MMP-9 NE that damage extracellular matrix triggering emphysema well spill over into systemic circulation. This study aimed determine correlation serum level blood absolute neutrophil count with diffusion capacity exercise stable COPD patients.Methods: A cross-sectional...

<p><strong>Pendahuluan: </strong>Prevalensi diabetes melitus (DM) secara global terus meningkat hingga menjadi 3 kali lipat pada tahun 2030. Volume kejadian yang tinggi tentu saja diikuti dengan beban biaya pula. Terapi DM tipe 2 saat ini hanya mencegah progresifitas dan komplikasi lebih parah. Salah satu inti tatalaksana adalah edukasi ke penderita untuk menjaga kadar gula darah, bagaimana diet baik, agar rutin selalu minum obat DM. Pengabdian dilakukan mengadakan...

Backgrounds: Chronic obstructive pulmonary disease is the leading cause morbidity and mortality worldwide. Cigarette smoke noxious agent causing oxidative stress activated nuclear factor-κB then increase inflammatory genes releases. Epigallocatechin-3-gallate green tea have antiiinflammatory effect which can be use as addition therapy for stable COPD.
 Methods: This study aimed to analyze of EGCG absolute neutrophil count (ANC), serum MMP-9, %FEV1, CAT score COPD patients. Clinical...

Background: Coronavirus disease 2019 (COVID-19) is an infectious caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2).Ground glass opacity, fibrous stripe, and thickening of adjacent pleura are frequently reported sequelae COVID-19.COVID-19 causing bronchiectasis in a previously healthy individual with no underlying lung conditions, has not been literature yet.Therefore, this case report aimed to highlight the importance COVID-19 infection-causing unusual changes such as...

Insidensi Diabetes Mellitus (DM) tipe 2 meningkat di Indonesia seiring dengan perubahan pola hidup masyarakat ke arah sedentary lifestyle. DM merupakan penyakit katastrofik karena angka kecacatan dan kematiannya cukup tinggi, serta memerlukan pembiayaan yang besar. Pengelolaan diabetes baik perlu melibatkan kemandirian penderita dalam hal diet, aktivitas fisik, pemakaian obat pemeriksaan gula darah berkala. Tujuan pengabdian ini adalah meningkatkan pemberdayaan tata kelola sehingga...

Background: Acute exacerbation of COPD (AECOPD) is a decrease in respiratory conditions compared with regular that require additional treatment, increase risk hospitalization or demand intensive care unit. The neutrophil-to-lymphocyte ratio (NLR) describes the balance between severity inflammation and immune system considered as an important systemic inflammatory marker. Length hospital stay (LHS) predicting AECOPD, which longer LHS indicates greater AECOPD. Secretome has been shown to have...

<p><strong>Introduction:</strong> A thyroid crisis is an endocrine emergency involving many organ systems and can be fatal to the patient's survival. Although cases of are rare, mortality rate significant which reaches 20–50%. The presence comorbidities such as pneumonia infection increases risk death dramatically. Infection a factor that trigger exacerbate thyrotoxicosis. This condition most often occurs in people with hyperthyroidism caused by Graves' disease. We present...

<p class="AbstractNormal"><strong>Introduction: </strong>Coronavirus Disease 2019 (Covid-19) can cause electrolyte imbalances, one of which is hypocalcemia. Hypocalcemia has been identified as a predictor the severity Covid-19. This research aimed to determine correlation between hypocalcemia and clinical degrees Covid-19 patients at UNS Hospital.</p><p class="AbstractNormal"><strong>Method: </strong>This study used cross-sectional design with...