Nagaendran Kandiah
A5006448874- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Neurological Disorders and Treatments
- Advanced Neuroimaging Techniques and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Frailty in Older Adults
- Cerebrovascular and genetic disorders
- Cholinesterase and Neurodegenerative Diseases
- Stroke Rehabilitation and Recovery
- Health Systems, Economic Evaluations, Quality of Life
- Neurobiology of Language and Bilingualism
- Ginkgo biloba and Cashew Applications
- Health, Environment, Cognitive Aging
- Retinal Imaging and Analysis
- Family Caregiving in Mental Illness
- Intensive Care Unit Cognitive Disorders
- Diet and metabolism studies
- Cardiovascular Health and Disease Prevention
Duke-NUS Medical School
2016-2025
Nanyang Technological University
2020-2025
National University of Singapore
2012-2025
Tan Tock Seng Hospital
2012-2024
National Neuroscience Institute
2015-2024
National University Hospital
2023-2024
Biomedical Research Institute
2024
Hospital de Sant Pau
2024
University College London
2024
National Medical Research Council
2023
Abstract Introduction Progress in understanding and management of vascular cognitive impairment (VCI) has been hampered by lack consensus on diagnosis, reflecting the use multiple different assessment protocols. A large multinational group clinicians researchers participated a two‐phase Vascular Impairment Cognition Classification Consensus Study (VICCCS) to agree principles (VICCCS‐1) protocols (VICCCS‐2) for diagnosis VCI. We present VICCCS‐2. Methods used VICCCS‐1 published diagnostic...
<h3>Objective</h3> To address the variability in prevalence estimates and inconsistencies potential risk factors for poststroke cognitive impairment (PSCI) using a standardized approach individual participant data (IPD) from international cohorts Stroke Cognition Consortium (STROKOG) consortium. <h3>Methods</h3> We harmonized 13 studies based 8 countries. Neuropsychological test scores 2 to 6 months after stroke or TIA appropriate normative were used calculate domain scores. Domain-specific...
Abstract Introduction Numerous diagnostic criteria have tried to tackle the variability in clinical manifestations and problematic diagnosis of vascular cognitive impairment (VCI) but none been universally accepted. These not readily comparable, impacting on rates turn prevalence estimates, research, treatment. Methods The Vascular Impairment Cognition Classification Consensus Study (VICCCS) involved participants (81% academic researchers) from 27 countries an online Delphi consensus study....
Abstract Cerebral hypoperfusion and impaired autophagy are two etiological factors that have been identified as being associated with the development of Alzheimer’s disease (AD). Nevertheless, exact relationships among these pathological processes remain unknown. To elucidate impact cerebral in AD, we created a unilateral common carotid artery occlusion (UCCAO) model by occluding left both young old 3xTg-AD mice. Two months after occlusion, found ligation increases phospho-Tau (p-Tau) at...
Hippocampal atrophy has been associated with mild cognitive impairment (MCI) in Parkinson's disease (PD). However, literature on how hippocampal affects the pathophysiology of PD limited. Previous studies assessed hippocampus as an entire entity instead their individual subregions. We studied progression status subjects over 18 relation to subfields atrophy. 65 were included. Using MDS task force criteria, classified either having no (PD-NCI) or PD-MCI. extended study by investigating...
Abstract Background Continuous assessment and remote monitoring of cognitive function in individuals with mild impairment (MCI) enables tracking therapeutic effects modifying treatment to achieve better clinical outcomes. While standardized neuropsychological tests are inconvenient for this purpose, wearable sensor technology collecting physiological behavioral data looks promising provide proxy measures function. The objective study was evaluate the predictive ability digital features,...
Team-based learning (TBL), a new active method, has not been reported for neurology education. We aimed to determine if TBL was more effective than passive (PL) in improving knowledge outcomes two key topics - neurological localization and emergencies. conducted modified crossover study during nine-week internal medicine posting involving 49 third-year medical undergraduates, using as the intervention, compared against self-reading PL control, teaching topics. Primary outcome mean percentage...
The contribution of vascular pathology to the rate progression from mild cognitive impairment (MCI) Alzheimer's disease (AD) remains unclear.To ascertain relative roles cerebral white matter and medial temporal atrophy (MTA) in predicting MCI AD.MCI patients with baseline MRI ≥18 months longitudinal follow-up were evaluated. DSM-IV-TR criteria used diagnose conversion dementia. MTA hyperintensity (WMH) quantified using Scheltens scale modified Fazekas scale.Of a total 171 patients, 79...
<h3>BACKGROUND AND PURPOSE:</h3> The involvement of subcortical deep gray matter and cortical thinning associated with mild Parkinson disease remains poorly understood. We assessed thickness volumes in patients without dementia evaluated their associations cognitive dysfunction. <h3>MATERIALS METHODS:</h3> study included 90 dementia. Neuropsychological assessments classified the sample into impairment (<i>n</i> = 25) 65). Volumetric data for structures were obtained by using FMRIB Integrated...
<h3>Objective:</h3> To identify regional brain metabolic dysfunctions associated with neuropsychiatric symptoms (NPS) in preclinical Alzheimer disease (AD). <h3>Methods:</h3> We stratified 115 cognitively normal individuals into AD (both amyloid and tau pathologies present), asymptomatic at risk for (either or pathology healthy controls (no present) using [<sup>18</sup>F]florbetapir PET CSF phosphorylated biomarkers. Regression voxel-based regression models evaluated the relationships...
The Stroke and Cognition consortium (STROKOG) aims to facilitate a better understanding of the determinants vascular contributions cognitive disorders help improve diagnosis treatment (VCD).
Abstract Background Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) cause distinct atrophy functional disruptions within two major intrinsic brain networks, namely the default network salience network, respectively. It remains unclear if inter-network relationships whole-brain topology are also altered underpin cognitive social–emotional deficits. Methods In total, 111 participants (50 AD, 14 bvFTD, 47 age- gender-matched healthy controls) underwent...
Mild cognitive impairment (MCI) is an important clinical entity with significant management implications. However, traditional screening tools lack the sensitivity needed to detect amnestic MCI (MCI-A). Montreal Cognitive Assessment (MoCA) has yet be validated for diagnosis of in a multiracial society such as Singapore. We thus aimed study effectiveness MoCA MCI-A Singapore population.Data on patients and mild Alzheimer's disease (AD) was obtained from prospectively collected database...
Background: Post stroke cognitive impairment (PSCI), an important complication of strokes, has numerous risk factors. A scale adequately classifying 3–6 months after mild will be useful for clinicians. Objective: To develop a score based on clinical and neuroimaging variables that in identifying ischemic patients at high PSCI. Methods: The development cohort comprised retrospective dataset 209 with MRI confirmed infarcts, without pre-stroke impairment, evaluated within 6 post-stroke Logistic...