A5086287565- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and genetic disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced MRI Techniques and Applications
- Neurological Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Medical Image Segmentation Techniques
- Neurosurgical Procedures and Complications
- Venous Thromboembolism Diagnosis and Management
- Neurological disorders and treatments
- Brain Tumor Detection and Classification
- Moyamoya disease diagnosis and treatment
- Intracranial Aneurysms: Treatment and Complications
- Neurological and metabolic disorders
- Anesthesia and Neurotoxicity Research
Radboud University Nijmegen
2016-2025
Radboud University Medical Center
2016-2025
University Medical Center
2004-2024
Biomedical Research Institute
2024
Hospital de Sant Pau
2024
University College London
2024
University Medical Center Utrecht
2000-2024
Central South University
2022-2024
Guangdong Academy of Medical Sciences
2022-2024
University of Basel
2022-2024
Cerebral white matter lesions (WMLs) have been associated with cognitive dysfunction. Whether periventricular or subcortical WMLs relate differently to function is still uncertain. In addition, it unclear whether are related specific domains such as memory psychomotor speed. We examined the relationship between and functioning in 1,077 elderly subjects randomly sampled from general population. Quantification of was assessed by means an extensive rating scale on 1.5-T magnetic resonance...
Cerebral white matter lesions (WMLs) have been associated with cognitive dysfunction. Whether periventricular or subcortical WMLs relate differently to function is still uncertain. In addition, it unclear whether are related specific domains such as memory psychomotor speed. We examined the relationship between and functioning in 1,077 elderly subjects randomly sampled from general population. Quantification of was assessed by means an extensive rating scale on 1.5-T magnetic resonance...
Background: There is evidence for a vascular cause of late-life depression.Cerebral white matter lesions are thought to represent abnormalities.White have been related affective disorders and history late-onset depression in psychiatric patients.Their relation with mood disturbances the general population not known.We investigated between presence depressive symptoms or population-based study.Methods: In sample 1077 nondemented elderly adults, we assessed severity subcortical periventricular...
Abstract The prospect of declining cognitive functions is a major fear for many elderly persons. Cerebral white matter lesions, as commonly found with magnetic resonance imaging, have been associated dysfunction in cross‐sectional studies. Only few longitudinal studies using small cohorts confirmed these findings. We examined the relation between severity lesions and decline over nearly 10‐year period 563 subjects sampled from general nondemented Dutch population. Severity was scored...
Objective To establish a fully automated, robust imaging marker for cerebral small vessel disease (SVD) and related cognitive impairment that is easy to implement, reflects burden, strongly associated with processing speed, the predominantly affected domain in SVD. Methods We developed novel magnetic resonance based on diffusion tensor imaging, skeletonization of white matter tracts, histogram analysis. The (peak width skeletonized mean diffusivity [PSMD]) was assessed along conventional SVD...
Delirium is often unrecognized in ICU patients and associated with poor outcome. Screening for delirium recommended by several medical organizations to improve early diagnosis treatment. The Confusion Assessment Method the (CAM-ICU) has high sensitivity specificity when administered research nurses. However, test characteristics of CAM-ICU as performed routine practice are unclear.To investigate diagnostic value daily practice.Teams three experts including psychiatrists, geriatricians,...
To investigate incidence of stroke and its subtypes in young adults, according to sex age, study trends over time.We established a nationwide cohort through linkage national registries (hospital discharge, cause death, population register) with patients aged 18-50 years those ≥50 first-ever ischemic stroke, intracerebral hemorrhage, or unspecified using ICD-9/ICD-10 codes between 1998 2010 the Netherlands. Outcomes were yearly stratified by sex, subtype, changes time, comparison years.We...
The anatomical location of imaging features is crucial importance for accurate diagnosis in many medical tasks. Convolutional neural networks (CNN) have had huge successes computer vision, but they lack the natural ability to incorporate their decision making process, hindering success some image analysis In this paper, integrate information into network, we propose several deep CNN architectures that consider multi-scale patches or take explicit while training. We apply and compare proposed...
LEADINGcausesofmortality,withanannual 6 million fatal events worldwide. 1 Stroke mainly affects elderly people, yet approximately 10% of strokes occur in patients younger than 50 years. 24][5][6][7][8][9] Itisexactlythislong-termprognosis that is particularly important adults these ages, given they have a long life expectancy during demanding time which are beginning their families and building careers.Thetermyoungstrokeisusedherein to refer stroke occurs aged 18 through years.The prognosis...
Previous studies have linked the MRI measures of perivascular spaces (PVSs), diffusivity along (DTI-ALPS), and free water (FW) to cerebral small vessel disease (SVD) SVD-related cognitive impairments. However, on longitudinal associations between three measures, SVD progression, decline are lacking. This study aimed explore how PVS, DTI-ALPS, FW contribute progression decline.
A quarter of ischaemic strokes are lacunar subtype, typically neurologically mild, usually resulting from intrinsic cerebral small vessel pathology, with risk factor profiles and outcome rates differing other stroke subtypes. This European Stroke Organisation (ESO) guideline provides evidence-based recommendations to assist clinical decisions about management prevent adverse outcomes. The was developed according ESO standard operating procedures Grading Recommendations, Assessment,...
This paper discusses methods for reconstructing theories underlying programs and policies. It describes three approaches. One is empirical–analytical in nature focuses on interviews, documents argumentational analysis. The second has strategic assessment, group dynamics, dialogue as its core. third cognitive organizational psychology foundation. For each of the approaches, case-illustrations are given. These approaches can help to make process program more open scrutiny. important because...
White matter lesions are often observed on cerebral magnetic resonance imaging scans of elderly people and may play a role in the pathogenesis dementia. Cross-sectional studies have shown an association between elevated blood pressure white lesions. We prospectively studied relation 1,077 subjects aged 60 to 90 years who were randomly sampled from two prospective population-based studies. One study had measurements 20 before, other 5 before. Overall response for was 63%, declined 73% among...
Abstract Background Cerebral small vessel disease (SVD) is a frequent finding on CT and MRI scans of elderly people related to vascular risk factors cognitive motor impairment, ultimately leading dementia or parkinsonism in some. In general, the relations are weak, not all subjects with SVD become demented get parkinsonism. This might be explained by diversity underlying pathology both white matter lesions (WML) normal appearing (NAWM). Both cannot properly appreciated conventional MRI....
Cerebral small vessel disease, including white matter hyperintensities (WMH) and lacunes of presumed vascular origin, is common in elderly people related to cognitive impairment dementia. One possible mechanism could be the disruption tracts (both within WMH normal-appearing matter) that connect distributed brain regions involved functions. Here, we investigated relation between microstructural integrity functions patients with disease. The Radboud University Nijmegen Diffusion tensor...