A5063509357- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Alzheimer's disease research and treatments
- Neurosurgical Procedures and Complications
- Cerebrovascular and genetic disorders
- Dementia and Cognitive Impairment Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
- Atrial Fibrillation Management and Outcomes
- MRI in cancer diagnosis
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer-related gene regulation
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Cardiac Arrhythmias and Treatments
- Neurological Disorders and Treatments
- Kruppel-like factors research
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Phagocytosis and Immune Regulation
- Biotin and Related Studies
Harvard University
2016-2025
Massachusetts General Hospital
2016-2025
American Heart Association
2000-2024
Leiden University Medical Center
2009-2024
Humboldt-Universität zu Berlin
2023
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2023
Freie Universität Berlin
2023
Centre Hospitalier Universitaire de Tours
2023
Chulalongkorn University
2014-2023
Brigham and Women's Hospital
2008-2023
Purpose— The aim of this guideline is to present current and comprehensive recommendations for the diagnosis treatment spontaneous intracerebral hemorrhage. Methods— A formal literature search PubMed was performed through end August 2013. writing committee met by teleconference discuss narrative text recommendations. Recommendations follow American Heart Association/American Stroke Association methods classifying level certainty effect class evidence. Prerelease review draft 6 expert peer...
Purpose— The aim of this guideline is to present current and comprehensive recommendations for the diagnosis treatment acute spontaneous intracerebral hemorrhage. Methods— A formal literature search MEDLINE was performed. Data were synthesized with use evidence tables. Writing committee members met by teleconference discuss data-derived recommendations. American Heart Association Stroke Council’s Levels Evidence grading algorithm used grade each recommendation. Prerelease review draft...
The authors performed clinical–pathologic correlation to assess the validity of Boston diagnostic criteria for cerebral amyloid angiopathy (CAA). Thirteen subjects were diagnosed clinically with probable CAA from among 39 patients available pathologic tissue in a prospective cohort aged ≥55 years primary lobar hemorrhage. All 13 individuals confirmed neuropathologically as having CAA. This small series indicates that diagnosis can be made during life high accuracy.
Indications for cardiac-resynchronization therapy (CRT) in patients with heart failure include a prolonged QRS interval (≥120 msec), addition to other functional criteria. Some narrow complexes have echocardiographic evidence of left ventricular mechanical dyssynchrony and may also benefit from CRT.
Warfarin sodium is highly effective for prevention of embolic stroke, particularly in nonvalvular atrial fibrillation, but its expected benefit can be offset by risk intracerebral hemorrhage (ICH). We studied the determinants ICH outcome to quantify independent effect warfarin.Consecutive patients with supratentorial treated a tertiary care hospital neurointensive unit were prospectively identified during 7-year period, and data on location, clinical characteristics, warfarin use collected....
<b><i>Background:</i></b> Warfarin increases mortality of intracerebral hemorrhage (ICH). The authors investigated whether this effect reflects increased baseline ICH volume at presentation or expansion. <b><i>Methods:</i></b> Subjects were drawn from an ongoing prospective cohort study outcome. warfarin on was studied in 183 consecutive cases supratentorial age ≥ 18 years admitted to the emergency department over a 5-year period. Baseline determined using computerized volumetric analysis....
Background: The risk for atrial fibrillation–associated stroke increases at low anticoagulation intensities. However, higher intensities increase hemorrhage risk. Optimal use of warfarin fibrillation requires precise information on the intracranial as a function patient age and intensity. Objective: To examine relationship age, intensity, hemorrhage. Design: Case–control study. Setting: Academic medical center. Patients: 170 case-patients who developed during therapy 1020 matched controls...
Abstract Cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular deposition of the β‐peptide, leading to intracerebral hemorrhage in severe cases. Other than rare familial cases, only identified risks for CAA are advancing age and accompanying Alzheimer's disease. We tested whether apolipoprotein E ϵ4 (apoE ϵ4) allele was associated with this association independent The apoE genotype determined without knowledge pathology 93 postmortem cases systematically graded severity 15...
Several mutations in the amyloid precursor protein (APP) gene have been found to associate with pathologic deposition of β-amyloid peptide (Aβ) neuritic plaques or walls cerebral vessels. We report a mutation at novel site APP three-generation Iowa family autosomal dominant dementia beginning sixth seventh decade life. The proband and an affected brother had progressive aphasic dementia, leukoencephalopathy, occipital calcifications. Neuropathological examination revealed severe angiopathy,...
Small asymptomatic cerebral hemorrhages detectable by gradient-echo MRI are common in patients with intracerebral hemorrhage (ICH), particularly lobar ICH related to amyloid angiopathy (CAA). We sought determine whether detected at the time of predict major clinical complications CAA: recurrent or decline cognition and function.Ninety-four consecutive survivors primary (age > =55) presentation were followed a prospective cohort study for 32.9+/-24.0 months. A subset 34 subjects underwent...
Abstract Lymphocyte activation gene-3 (LAG-3) is a CD4-related transmembrane protein expressed by regulatory T cells that binds MHC II on APCs. It shown in this study during Treg:DC interactions, LAG-3 engagement with class inhibits DC activation. cross-linking agonistic Abs induces an ITAM-mediated inhibitory signaling pathway, involving FcγRγ and ERK-mediated recruitment of SHP-1 suppresses dendritic cell maturation immunostimulatory capacity. These data reveal novel pathway DCs triggered...
Recurrent lobar intracerebral hemorrhage is the hallmark of cerebral amyloid angiopathy. The factors that predispose patients to early recurrence are unknown. One candidate apolipoprotein E gene, since both epsilon2 and epsilon4 alleles appear be associated with severity angiopathy.We performed a prospective, longitudinal study consecutive elderly who survived hemorrhage. were followed for recurrent hemorrhagic stroke by interviews at six-month intervals reviews medical records computed...
Abstract Objective Cerebrovascular deposition of β‐amyloid (cerebral amyloid angiopathy [CAA]) is a major cause hemorrhagic stroke and likely contributor to vascular cognitive impairment. We evaluated positron emission tomographic imaging with the β‐amyloid–binding compound Pittsburgh Compound B (PiB) as potential noninvasive method for detection CAA. hypothesized that would be observed PiB in CAA, based on occipital predilection CAA pathology associated hemorrhages, specific retention...
IP-10 is a member of the chemokine family cytokines and induced in variety cells response to interferon gamma lipopolysaccharide. The self-aggregation common many chemokines, including IP-10, has hindered identification specific receptor. Using an alkaline phosphatase fusion protein that fortuitously blocks this self-aggregation, we have identified binding site on endothelial, epithelial, hematopoietic cells. This Kd 25 nM, inhibited by recombinant murine or human dependent presence cell...