Richard I. Lindley
A5072218240- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Health Systems, Economic Evaluations, Quality of Life
- Frailty in Older Adults
- Neurosurgical Procedures and Complications
- Neurological Disorders and Treatments
- Influenza Virus Research Studies
- Dementia and Cognitive Impairment Research
- Cerebral Palsy and Movement Disorders
- Blood Pressure and Hypertension Studies
- Clinical practice guidelines implementation
- Retinal Imaging and Analysis
- Atrial Fibrillation Management and Outcomes
- Nutrition and Health in Aging
- S100 Proteins and Annexins
- Pneumonia and Respiratory Infections
- Pharmaceutical Practices and Patient Outcomes
- Retinal and Optic Conditions
- Renal and Vascular Pathologies
- Geriatric Care and Nursing Homes
- Balance, Gait, and Falls Prevention
The George Institute for Global Health
2016-2025
The University of Sydney
2016-2025
UNSW Sydney
2007-2025
Blacktown & Mount Druitt Hospital
2023-2025
Sydney Local Health District
2023-2025
Westmead Institute
2006-2025
Sichuan University
2016-2024
National Health and Medical Research Council
2014-2024
Soochow University
2024
NIHR Leicester Biomedical Research Centre
2024
Whether rapid lowering of elevated blood pressure would improve the outcome in patients with intracerebral hemorrhage is not known.We randomly assigned 2839 who had a spontaneous within previous 6 hours and systolic to receive intensive treatment lower their (with target level <140 mm Hg 1 hour) or guideline-recommended <180 Hg) use agents physician's choosing. The primary was death major disability, which defined as score 3 on modified Rankin scale (in 0 indicates no symptoms, 5 severe...
Early mobilisation after stroke is thought to contribute the effects of stroke-unit care; however, intervention poorly defined and not underpinned by strong evidence. We aimed compare effectiveness frequent, higher dose, very early with usual care stroke.We did this parallel-group, single-blind, randomised controlled trial at 56 acute units in five countries. Patients (aged ≥18 years) ischaemic or haemorrhagic stroke, first recurrent, who met physiological criteria were randomly assigned...
The bedside clinical assessment of the patient with suspected stroke has not been well studied. Improving skills may accelerate progress through emergency department. We aimed to determine frequency and nature mimics identify key features that distinguish between mimic at bedside.Consecutive presentations an urban teaching hospital were recruited. A standard was performed. final diagnosis determined by expert panel, which had access features, brain imaging, other tests. Univariate...
Thrombolytic therapy for acute ischemic stroke with a lower-than-standard dose of intravenous alteplase may improve recovery along reduced risk intracerebral hemorrhage.Using 2-by-2 quasi-factorial open-label design, we randomly assigned 3310 patients who were eligible thrombolytic (median age, 67 years; 63% Asian) to low-dose (0.6 mg per kilogram body weight) or the standard (0.9 kilogram); underwent randomization within 4.5 hours after onset stroke. The primary objective was determine...
Thrombolytic therapy with intravenous alteplase within 4.5 hours of ischemic stroke onset increases the overall likelihood an excellent outcome (no, or nondisabling, symptoms). Any improvement in functional distribution has value, and herein we provide assessment effect on level by treatment delay, age, severity.
Uncertainty exists over the size of potential beneficial effects medical treatments targeting hematoma growth in intracerebral hemorrhage (ICH). We report associations parameters on clinical outcomes pilot phase, Intensive Blood Pressure Reduction Acute Cerebral Hemorrhage Trial (INTERACT1) (ClinicalTrials.gov NCT00226096).In randomized patients with both baseline and 24-hour brain CT (n = 335), between measures absolute relative 90-day poor death dependency (modified Rankin Scale score 3-5)...
<h3>Objective:</h3> Our prespecified dose-response analyses of A Very Early Rehabilitation Trial (AVERT) aim to provide practical guidance for clinicians on the timing, frequency, and amount mobilization following acute stroke. <h3>Methods:</h3> Eligible patients were aged ≥18 years, had confirmed first (or recurrent) stroke, admitted a stroke unit within 24 hours onset. Patients randomized receive very early frequent mobilization, commencing hours, or usual care. We used regression...
<i>Background:</i> Explanations for associations found between sensory and cognitive function remain unclear. <i>Objective:</i> To assess in an older Australian population: (1) the correlation across groups with a narrow age range; (2) any independent association impairment. <i>Methods:</i> We examined 3,509 non-institutionalised residents aged 50+ years second cross-sectional survey of Blue Mountains Eye Study (1997–2000). Visual impairment was defined...
Background: Graduated compression stockings are widely used for deep venous thrombosis (DVT) prophylaxis. Although below-knee more often than thigh-length stockings, no reliable evidence indicates that they as effective stockings. Objective: To compare the effectiveness of with preventing proximal DVT in immobile, hospitalized patients stroke. Design: Parallel-group trial centralized randomization (minimization within centers) to ensure allocation concealment. The ultrasonographers who...
<b>Objective</b> To evaluate the effect of 6-PACK programme on falls and fall injuries in acute wards. <b>Design</b> Cluster randomised controlled trial. <b>Setting</b> Six Australian hospitals. <b>Participants</b> All patients admitted to 24 wards during trial period. <b>Interventions</b> Participating were randomly assigned receive either nurse led or usual care over 12 months. The included a risk tool individualised use one more six interventions: "falls alert"...
Rationale: The INTERACT pilot study demonstrated the feasibility of protocol, safety early intensive blood pressure lowering and effects on haematoma expansion within 6h onset intracerebral haemorrhage. This article describes design second, main phase, INTERACT2. Aims: To compare a management strategy with more conservative guideline-based policy in patients acute hemorrhage. Design: INTERACT2 is prospective, randomized, open label, assessor-blinded end-point (PROBE). Patients systolic...
<h3>Objective:</h3> To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). <h3>Methods:</h3> Associations ICH sites poor (death [6] or major disability [3–5] modified Rankin Scale) European Quality Life Scale (EQ-5D) utility scores at 90 days were assessed logistic regression models. <h3>Results:</h3> Of 2,066 patients included...