- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Neurological Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Meta-analysis and systematic reviews
- Health Systems, Economic Evaluations, Quality of Life
- Clinical practice guidelines implementation
- Peripheral Artery Disease Management
- S100 Proteins and Annexins
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Neurological Disease Mechanisms and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Ethics in Clinical Research
- COVID-19 Clinical Research Studies
- Health and Medical Research Impacts
- Lipoproteins and Cardiovascular Health
- Advanced MRI Techniques and Applications
University of Edinburgh
2014-2024
University of Oxford
1985-2023
Eijkman Institute for Molecular Biology
2021
National Health and Medical Research Council
2021
University of Dundee
2021
Medical Research Council
2013-2021
Nepal Health Research Council
2021
NIHR Clinical Research Network
2021
National Institute for Health Research
2021
National Records of Scotland
2021
Background and Purpose — Among patients with acute stroke, high blood pressure is often associated poor outcome, although the reason unclear. We analyzed data from International Stroke Trial (IST) to explore relationship between systolic (SBP), subsequent clinical events over next 2 weeks, functional outcome at 6 months in stroke. Methods included analysis 17 398 IST confirmed ischemic A single measurement of SBP was made immediately before randomization. Clinical within 14 days...
The age and sex specific incidence rates for cerebral infarction, primary intracerebral haemorrhage subarachnoid in a population of approximately 105,000 are presented. Over four years 675 patients with first-ever stroke were registered the Oxfordshire Community Stroke Project. pathological diagnosis was confirmed by computerised tomography (CT) scan, necropsy or lumbar puncture (cases only) 78% cases further 17% diagnosed according to Guy9s Hospital Diagnostic Score. proportion all strokes...
AimsNiacin has potentially favourable effects on lipids, but its effect cardiovascular outcomes is uncertain. HPS2-THRIVE a large randomized trial assessing the of extended release (ER) niacin in patients at high risk vascular events.
There have been relatively few community-based studies of long-term prognosis after acute stroke. This study aimed to provide precise estimates the absolute and relative risks dying in an unselected cohort patients with a first-ever Six hundred seventy-five were registered by stroke register (the Oxfordshire Community Stroke Project) prospectively followed up for 6.5 years. Their risk death was calculated using age- sex-specific mortality rates Oxfordshire. During first 30 days, 129 (19%)...
There have been few community-based studies of long-term prognosis after acute stroke. This study aims to provide precise estimates the absolute and relative risks stroke recurrence in an unselected cohort patients with a first-ever stroke.Six hundred seventy-five were registered register (the Oxfordshire Community Stroke Project) prospectively followed for up 6.5 years. Their risk recurrent was calculated using age- sex-specific incidence rates first Oxfordshire.One eighty episodes...
A prospective study of acute cerebrovascular disease in a community about 105,000 people is reported. The protocol combined rapid clinical assessment patients with accurate diagnosis the pathological type stroke by CT or necropsy, whether not they were admitted to hospital. population was defined as those who registered one 50 collaborating general practitioners (GPs). Referrals primarily from GPs though, ensure complete case ascertainment, hospital casualty and admission registers, death...