A5051317564- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Noise Effects and Management
- Hearing Impairment and Communication
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Blood properties and coagulation
- Neurosurgical Procedures and Complications
- Neurological Disorders and Treatments
- Atrial Fibrillation Management and Outcomes
- Ear Surgery and Otitis Media
- Cardiovascular Health and Disease Prevention
- Botulinum Toxin and Related Neurological Disorders
- Speech and Audio Processing
- Dementia and Cognitive Impairment Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Neurological Complications and Syndromes
- Cerebrovascular and genetic disorders
- Infant Health and Development
Leeds Teaching Hospitals NHS Trust
2002-2025
University of Leeds
1997-2025
Leeds General Infirmary
1999-2023
Health and Education Research Management and Epidemiologic Services (United States)
2023
Campbell Collaboration
2021
Foothills Medical Centre
2018
University of Calgary
2018
London School of Hygiene & Tropical Medicine
2017
The George Institute for Global Health
2015-2016
The University of Sydney
2015-2016
The age and sex specific incidence rates for cerebral infarction, primary intracerebral haemorrhage subarachnoid in a population of approximately 105,000 are presented. Over four years 675 patients with first-ever stroke were registered the Oxfordshire Community Stroke Project. pathological diagnosis was confirmed by computerised tomography (CT) scan, necropsy or lumbar puncture (cases only) 78% cases further 17% diagnosed according to Guy9s Hospital Diagnostic Score. proportion all strokes...
Linguistic guidelines for the design of sentences speech audiometry with children are described, and new lists test which based on such guidelines--the Bamford-Kowal-Bench Sentence Lists Children--are introduced. Audiometric data relating to use presented discussed.
There have been relatively few community-based studies of long-term prognosis after acute stroke. This study aimed to provide precise estimates the absolute and relative risks dying in an unselected cohort patients with a first-ever Six hundred seventy-five were registered by stroke register (the Oxfordshire Community Stroke Project) prospectively followed up for 6.5 years. Their risk death was calculated using age- sex-specific mortality rates Oxfordshire. During first 30 days, 129 (19%)...
There have been few community-based studies of long-term prognosis after acute stroke. This study aims to provide precise estimates the absolute and relative risks stroke recurrence in an unselected cohort patients with a first-ever stroke.Six hundred seventy-five were registered register (the Oxfordshire Community Stroke Project) prospectively followed for up 6.5 years. Their risk recurrent was calculated using age- sex-specific incidence rates first Oxfordshire.One eighty episodes...
<h3>Abstract</h3> <b>Objective:</b> To estimate the prevalence of confirmed permanent childhood hearing impairment and its profile across age degree in United Kingdom. <b>Design:</b> Retrospective total ascertainment through sources health education sectors by postal questionnaire. <b>Setting:</b> Hospital based otology audiology departments, community clinics, services for impaired children. <b>Participants:</b> Children born from 1980 to 1995, resident Kingdom 1998, with (hearing level...
A prospective study of acute cerebrovascular disease in a community about 105,000 people is reported. The protocol combined rapid clinical assessment patients with accurate diagnosis the pathological type stroke by CT or necropsy, whether not they were admitted to hospital. population was defined as those who registered one 50 collaborating general practitioners (GPs). Referrals primarily from GPs though, ensure complete case ascertainment, hospital casualty and admission registers, death...
In a consecutive series of 515 first-ever strokes in community-based study stroke that combined prompt clinical assessment by neurologist with high rate confirmed pathologic diagnosis, 108 cases (21%) had lacunar syndrome. A computed tomography (CT) scan was performed 104 (96%) these cases. Only 3 primary intracerebral hemorrhage, and another "inappropriate" areas infarcts were seen 34 the remaining 98 (35%) CT scans. The crude annual incidence infarction 0.33/1,000. There no excess risk...
<h3>Abstract</h3> <b>Objective:</b> To describe the immediate and long term risk of epileptic seizures after a first ever stroke. <b>Design:</b> Cohort study following up stroke survivors for 2 to 6.5 years; comparison with age specific incidence rates in general population. <b>Setting:</b> Community based register. <b>Subjects:</b> 675 patients stroke, followed minimum years. <b>Main outcome measures:</b> Occurrence single recurrent seizures. <b>Results:</b> 52 had one or more post...
Previous studies have reported mood symptoms after stroke to be a risk factor for later mortality. The purpose of the study was examine whether at 1 month may mortality 12 and 24 months.As cohort within randomized controlled trial, 448 hospital patients were seen into trial psychological therapy. Follow-up months. Mood assessed by Present State Examination General Health Questionnaire (GHQ)-28. Measures disability before cognitive impairment also taken month. Mortality determined months...
Results of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate these effects.FOCUS was pragmatic, multicentre, parallel group, double-blind, randomised, placebo-controlled done at 103 hospitals in the UK. Patients were eligible if they aged 18 years or older, had clinical stroke diagnosis, enrolled and randomly assigned between 2 days 15 onset, focal neurological deficits. allocated 20 mg matching placebo...
Cerebral microbleeds are a potential neuroimaging biomarker of cerebral small vessel diseases that prone to intracranial bleeding. We aimed determine whether presence can identify patients at high risk symptomatic haemorrhage when anticoagulated for atrial fibrillation after recent ischaemic stroke or transient attack.
BackgroundAntiplatelet therapy reduces the risk of major vascular events for people with occlusive disease, although it might increase intracranial haemorrhage. Patients surviving commonest subtype haemorrhage, intracerebral are at both haemorrhagic and events, but whether antiplatelet can be used safely is unclear. We aimed to estimate relative absolute effects on recurrent haemorrhage this exceed any reduction events.MethodsThe REstart or STop Antithrombotics Randomised Trial (RESTART) was...
Importance Cerebral small vessel disease (cSVD) is a common cause of stroke (lacunar stroke), the most vascular cognitive impairment, and impairs mobility mood but has no specific treatment. Objective To test feasibility, drug tolerability, safety, effects 1-year isosorbide mononitrate (ISMN) cilostazol treatment on vascular, functional, outcomes in patients with lacunar stroke. Design, Setting, Participants The Lacunar Intervention Trial-2 (LACI-2) was an investigator-initiated, open-label,...
The commonly quoted early risks of stroke after a first transient ischemic attack (TIA)-1% to 2% at 7 days and 4% 1 month-are likely be underestimates because the delay before inclusion into previous studies exclusion patients who had during this time. Therefore, it is uncertain how urgently TIA should assessed. We used data from Oxford Community Stroke Project (OCSP) estimate very risk investigated potential effects delays specialist assessment.All OCSP first-ever definite study period...
In a community-based study of approximately 105,000 people, 184 presented with transient ischemic attack during the 5 years between 1981 and 1986; we believe these persons represent almost all new cases going to doctor that period. During mean follow-up 3.7 49 patients died, 45 had first-ever stroke, 17 myocardial infarction. Cardiac disease accounted for (35%) deaths, while stroke was cause death in 15 (31%). The average actuarial risk 6.3%/yr, slightly greater than expected similar people...
The Brompton mixture is widely used as an effective method for controlling pain in cancer patients. In a double-blind crossover trial standard containing morphine, cocaine, ethyl alcohol, syrup BP and chloroform water was compared with morphine alone flavoured aqueous solution; both were administered orally. Pain measured by means of the intensity index McGill Questionnaire. Ratings confusion, nausea drowsiness obtained from patients their nurses relatives. data showed that there no...
OBJECTIVE--To determine in patients with first ever stroke whether atrial fibrillation influences clinical features, the need to perform computed tomography, and prognosis. DESIGN--Observational cohort study maximum follow up of 6.5 years. SETTING--Primary care, based on 10 general practices urban rural Oxfordshire. SUBJECTS--Consecutive series 675 registered Oxfordshire community project. MAIN OUTCOME MEASURES--Prevalence by type stroke; effect case fatality rate risk recurrent stroke,...
We tested the hypothesis that hypertension is more common and cardiac embolism less in patients with lacunar infarction than other types of cerebral infarction. studied risk factor profiles a series 102 consecutive infarct 202 carotid artery-distribution involving cortex registered Oxfordshire Community Stroke Project, community-based study first-ever stroke. The two groups did not differ prevalence prestroke (defined number ways) or markers sustained hypertension. presence atrial...