A5025336226- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations Diagnosis and Treatment
- Peripheral Artery Disease Management
- Neurosurgical Procedures and Complications
- Clinical practice guidelines implementation
- Healthcare Systems and Practices
- Moyamoya disease diagnosis and treatment
- Retirement, Disability, and Employment
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes and associated disorders
- Health Systems, Economic Evaluations, Quality of Life
- Medical Imaging and Analysis
- Diabetes Management and Research
- Radiology practices and education
- Aortic aneurysm repair treatments
- Atrial Fibrillation Management and Outcomes
- Gestational Diabetes Research and Management
- Cerebrospinal fluid and hydrocephalus
- Testicular diseases and treatments
Newcastle University
2016-2025
Newcastle upon Tyne Hospitals NHS Foundation Trust
2017-2024
University of Newcastle Australia
2014-2024
ORCID
2024
British Heart Foundation
2024
Health Data Research UK
2024
Newcastle upon Tyne Hospital
2018-2023
Prisma Health
2023
Health and Education Research Management and Epidemiologic Services (United States)
2021-2023
Université de Reims Champagne-Ardenne
2023
Mechanical thrombectomy (MT) has become the cornerstone of acute ischaemic stroke management in patients with large vessel occlusion (LVO). The aim this guideline document is to assist physicians their clinical decisions regard MT.These Guidelines were developed based on standard operating procedure European Stroke Organisation and followed Grading Recommendations, Assessment, Development, Evaluation (GRADE) approach. An interdisciplinary working group identified 15 relevant questions,...
Mechanical thrombectomy (MT) has become the cornerstone of acute ischemic stroke management in patients with large vessel occlusion (LVO).To assist physicians their clinical decisions regard toMT.These guidelines were developed based on standard operating procedure European Stroke Organisation and followed Grading Recommendations, Assessment, Development, Evaluation (GRADE) approach. An interdisciplinary working group identified 15 relevant questions, performed systematic reviews...
Background Mechanical thrombectomy (MT) has become the cornerstone of acute ischemic stroke management in patients with large vessel occlusion (LVO). The aim this guideline document is to assist physicians their clinical decisions regard MT. Methods These guidelines were developed based on standard operating procedure European Stroke Organisation, and followed Grading Recommendations, Assessment, Development, Evaluation (GRADE) approach. An interdisciplinary working group identified 15...
Revascularization after endovascular therapy for acute ischemic stroke is measured by the Thrombolysis In Cerebral Infarction (TICI) scale, yet variability exists in scale definitions. We examined degree of reperfusion with expanded TICI (eTICI) and association outcomes HERMES collaboration recent trials.The Imaging Core, blind to all other data, evaluated angiography HERMES. A battery scores (mTICI, TICI, TICI2C) was used define initial target occlusion defined non-invasive imaging...
The Pragmatic Ischaemic Thrombectomy Evaluation (PISTE) trial was a multicentre, randomised, controlled clinical comparing intravenous thrombolysis (IVT) alone with IVT and adjunctive intra-arterial mechanical thrombectomy (MT) in patients who had acute ischaemic stroke large artery occlusive anterior circulation confirmed on CT angiography (CTA).Eligible started within 4.5 hours of symptom onset. Those randomised to additional MT underwent using any Conformité Européene (CE)-marked device,...
Identification of lobar spontaneous intracerebral haemorrhage associated with cerebral amyloid angiopathy (CAA) is important because it a higher risk recurrent than arteriolosclerosis-associated haemorrhage. We aimed to develop prediction model for the identification CAA-associated using CT features and genotype.
<h3>Importance</h3> Whether conservative management is superior to interventional treatment for unruptured brain arteriovenous malformations (bAVMs) uncertain because of the shortage long-term comparative data. <h3>Objective</h3> To compare outcomes vs intervention bAVM. <h3>Design, Setting, and Population</h3> Population-based inception cohort study 204 residents Scotland aged 16 years or older who were first diagnosed as having an bAVM during 1999-2003 2006-2010 followed up prospectively...
BackgroundAntiplatelet therapy reduces the risk of major vascular events for people with occlusive disease, although it might increase intracranial haemorrhage. Patients surviving commonest subtype haemorrhage, intracerebral are at both haemorrhagic and events, but whether antiplatelet can be used safely is unclear. We aimed to estimate relative absolute effects on recurrent haemorrhage this exceed any reduction events.MethodsThe REstart or STop Antithrombotics Randomised Trial (RESTART) was...
Six randomized controlled clinical trials have assessed whether mechanical thrombectomy (MT) alone is non-inferior to intravenous thrombolysis (IVT) plus MT within 4.5 hours of symptom onset in patients with anterior circulation large vessel occlusion (LVO) ischemic stroke and no contraindication IVT. An expedited recommendation process was initiated by the European Stroke Organisation (ESO) conducted Society Minimally Invasive Neurological Therapy (ESMINT) according ESO standard operating...
Six randomized controlled clinical trials have assessed whether mechanical thrombectomy (MT) alone is non-inferior to intravenous thrombolysis (IVT) plus MT within 4.5 hours of symptom onset in patients with anterior circulation large vessel occlusion (LVO) ischaemic stroke and no contraindication IVT. An expedited recommendation process was initiated by the European Stroke Organisation (ESO) conducted Society Minimally Invasive Neurological Therapy (ESMINT) according ESO standard operating...
To compare computed tomographic (CT) angiography and magnetic resonance (MR) with intraarterial digital subtraction (DSA) in the detection of intracranial aneurysms.One hundred forty-two patients underwent DSA to detect aneurysms. CT angiography, three-dimensional time-of-flight MR were performed contemporaneously. Film hard-copy images maximum intensity projection reconstructions angiograms reviewed at different times.The accuracy per patient for best observer was 0.87 0.85 angiography. The...
The characteristics of intracerebral hemorrhage (ICH) may vary by ICH location because differences in the distribution underlying cerebral small vessel diseases. Therefore, we investigated incidence, characteristics, and outcome lobar nonlobar ICH.In a population-based, prospective inception cohort study ICH, used multiple overlapping sources case ascertainment follow-up to identify validate diagnoses 2010 2011 an adult population 695 335.There were 128 participants with first-ever primary...