Jonathan Carter
A5077922970- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Cervical Cancer and HPV Research
- Endometriosis Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Bariatric Surgery and Outcomes
- Enhanced Recovery After Surgery
- Colorectal Cancer Surgical Treatments
- Intraperitoneal and Appendiceal Malignancies
- Gastric Cancer Management and Outcomes
- COVID-19 Clinical Research Studies
- Multiple Sclerosis Research Studies
- Genital Health and Disease
- Hernia repair and management
- Minimally Invasive Surgical Techniques
- Gynecological conditions and treatments
- BRCA gene mutations in cancer
- Autoimmune Neurological Disorders and Treatments
- Testicular diseases and treatments
- Colorectal and Anal Carcinomas
- Gestational Trophoblastic Disease Studies
- Renal cell carcinoma treatment
- Cancer survivorship and care
- SARS-CoV-2 and COVID-19 Research
Royal Prince Alfred Hospital
2012-2024
The University of Melbourne
1977-2024
Coventry University
2020-2024
University of California, San Francisco
2013-2024
Warwick Hospital
2024
Edinburgh Royal Infirmary
2015-2024
NHS Lothian
2024
University of Oxford
2022-2023
Institute of Biomedical Science
2023
Max Planck Institute for Gravitational Physics
2023
Background: Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), often termed Hashimoto encephalopathy, is a poorly understood and misdiagnosed entity.Objective: To characterize the clinical, laboratory, radiologic findings in patients SREAT to potentially improve recognition of this treatable entity.Design: Retrospective analysis clinical features diagnostic test data.Setting: Two affiliated tertiary care referral institutions.Patients: Twenty consecutive (6...
<h3>Background</h3> Neuromyelitis optica (NMO) is the first inflammatory autoimmune demyelinating disease of central nervous system for which a specific antigenic target has been identified; marker autoantibody NMO-IgG specifically recognizes astrocytic water channel aquaporin 4. Current evidence strongly suggests that may be pathogenic. Since disability accrues incrementally related to attacks, attack prevention with immunosuppressive therapy mainstay preventing disability....
Abstract Accurately identifying patients with high-grade serous ovarian carcinoma (HGSOC) who respond to poly(ADP-ribose) polymerase inhibitor (PARPi) therapy is of great clinical importance. Here we show that quantitative BRCA1 methylation analysis provides new insight into PARPi response in preclinical models and cancer patients. The 12 HGSOC patient-derived xenografts (PDX) the rucaparib was assessed, variable dose-dependent responses observed chemo-naive BRCA1/2 -mutated PDX, no PDX...
The rate and clinical features of patients admitted to King George V Hospital with extraovarian peritoneal serous papillary carcinoma during a 9-year period were reviewed. In this time, 31 236 (13%) an initial diagnosis invasive ovarian fulfilled the surgicopathologic criteria for entity. All had disseminated tumor equivalent Stage III IV disease (International Federation Gynecology Obstetrics [FIGO]) predominantly high-grade neoplasms. They managed by surgical exploration, debulking where...
The characteristics of intracerebral hemorrhage (ICH) may vary by ICH location because differences in the distribution underlying cerebral small vessel diseases. Therefore, we investigated incidence, characteristics, and outcome lobar nonlobar ICH.In a population-based, prospective inception cohort study ICH, used multiple overlapping sources case ascertainment follow-up to identify validate diagnoses 2010 2011 an adult population 695 335.There were 128 participants with first-ever primary...
Gastrointestinal (GI) bleeding causes more than 300 000 hospitalizations per year in the United States. Imaging plays a crucial role accurately locating source of bleed for timely intervention. Magnetic particle imaging (MPI) is an emerging clinically translatable modality that images superparamagnetic iron-oxide (SPIO) tracers with extraordinary contrast and sensitivity. This linearly quantitative has zero background tissue signal depth attenuation. MPI also safe: there ionizing radiation...
Abstract Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood spleen. Using expression quantitative trait loci (eQTL) reported these identify 26 previously unreported, likely target genes of overall risk variants, 17 for estrogen receptor (ER)-negative cancer, several with a known function. We...
Most BRCA1 or BRCA2 mutation carriers have inherited a single (heterozygous) mutation. Transheterozygotes (TH) who deleterious mutations in both and are rare, the consequences of transheterozygosity poorly understood. From 32,295 female BRCA1/2 carriers, we identified 93 TH (0.3 %). "Cases" were defined as TH, "controls" at (SH1) (SH2). Matched SH1 carried found "case". SH2 After matching with SH2, 91 matched to 9316 SH1, 89 3370 SH2. The majority (45.2 %) involved three common Jewish...
For patients with recurrent inguinal hernia, or bilateral for women, laparoscopic repair offers significant advantages over open techniques regard to recurrence risk, pain, and recovery. unilateral first-time hernias, either mesh can offer excellent results. The major drawback of laparoscopy is that the technique requires a number cases master. surgeons in group practice, it makes sense have one surgeon perform repairs so experience be concentrated. others, best remains approach most...
The relationship between diet and survival after ovarian cancer diagnosis is unclear as a result of limited number studies inconsistent findings. We examined the association pre-diagnostic overall in population-based cohort (n=811) Australian women diagnosed with invasive epithelial 2002 2005. Diet was measured by validated food frequency questionnaire. Deaths were ascertained up to 31 August 2014 via medical record review National Death Index linkage. conducted Cox proportional hazards...
To assess, in a surgical biopsy cohort of active demyelinating lesions, the diagnostic utility aquaporin-4 (AQP4) immunohistochemistry identifying neuromyelitis optica (NMO) or NMO spectrum disorder (NMOSD) and describe pathologic features that should prompt AQP4 immunohistochemical analysis AQP4-immunoglobulin G (IgG) serologic testing.This was neuropathologic study 20 biopsies (19 patients; 11 cord/9 brain), performed because uncertainty, interpreted as disease containing 2 more following...
Abstract Previous transcriptome‐wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome‐wide (GWAS), but analyses of subtype‐specific associations been limited. In this study, we conducted a TWAS using gene GTEx summary statistics the hitherto largest GWAS meta‐analysis for overall, estrogen receptor subtypes (ER+ ER−). We further compared with ER+ ER− subtypes, case‐only approach. also multigene conditional in...
To evaluate the prognostic significance of preoperative CA-125 levels on overall survival patients with International Federation Gynecology and Obstetrics (FIGO) stage I epithelial ovarian cancer (EOC).Data from 518 FIGO EOC treated in seven gynecologic oncology centers throughout Australia between 1990 2002 were analyzed. Patients borderline tumors nonepithelial carcinomas excluded, as women whom had not been determined preoperatively. Preoperative studied surgically staged incompletely...