Mathias Buttmann
A5057863942- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- Hereditary Neurological Disorders
- Inflammasome and immune disorders
- Ocular Diseases and Behçet’s Syndrome
- CAR-T cell therapy research
- Barrier Structure and Function Studies
- Monoclonal and Polyclonal Antibodies Research
- Signaling Pathways in Disease
- Rheumatoid Arthritis Research and Therapies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Viral Infections and Immunology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- NF-κB Signaling Pathways
- RNA Interference and Gene Delivery
- Sarcoidosis and Beryllium Toxicity Research
- interferon and immune responses
- RNA regulation and disease
- Caveolin-1 and cellular processes
Caritas-Krankenhaus Bad Mergentheim
2018-2024
Universitätsklinikum Würzburg
2011-2021
University of Würzburg
2009-2020
Heinrich Heine University Düsseldorf
2019
Humboldt State University
2019
NeuroRx Research (Canada)
2018
Vrije Universiteit Amsterdam
2018
Comprehensive Cancer Center Mainfranken
2016
Klinik und Poliklinik für Neurologie
2010-2015
Klinikum Aschaffenburg
2015
A subset of patients with neuromyelitis optica spectrum disorders (NMOSD) has been shown to be seropositive for myelin oligodendrocyte glycoprotein antibodies (MOG-IgG). To describe the epidemiological, clinical, radiological, cerebrospinal fluid (CSF), and electrophysiological features a large cohort MOG-IgG-positive optic neuritis (ON) and/or myelitis (n = 50) as well attack long-term treatment outcomes. Retrospective multicenter study. The sex ratio was 1:2.8 (m:f). Median age at onset 31...
Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have been suggested play a role in subset of patients with neuromyelitis optica and related disorders.To assess (i) the frequency MOG-IgG large predominantly Caucasian cohort optic neuritis (ON) and/or myelitis; (ii) among AQP4-IgG-positive vice versa; (iii) origin cerebrospinal fluid (CSF); (iv) presence at disease onset; (v) influence activity treatment status on titers.614 serum samples from ON myelitis controls, including 92...
Myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) are present in a subset of aquaporin-4 (AQP4)-IgG-negative patients with optic neuritis (ON) and/or myelitis. Little is known so far about brainstem involvement MOG-IgG-positive patients. To investigate the frequency, clinical and paraclinical features, course, outcome, prognostic implications ON Retrospective case study. Among 50 myelitis, 15 (30 %) history encephalitis were identified. All negative for AQP4-IgG. Symptoms included...
Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been reported in patients with aquaporin-4 antibody (AQP4-IgG)-negative neuromyelitis optica spectrum disorders (NMOSD). The objective of this study was to describe optic neuritis (ON)-induced neuro-axonal damage the retina MOG-IgG-positive comparison AQP4-IgG-positive NMOSD patients.Afferent visual system following ON bilaterally assessed 16 a history and compared that patients. In addition, healthy controls matched for...
To analyze whether 1 of the 2 apheresis techniques, therapeutic plasma exchange (PE) or immunoadsorption (IA), is superior in treating neuromyelitis optica spectrum disorder (NMOSD) attacks and to identify predictive factors for complete remission (CR).This retrospective cohort study was based on registry German Neuromyelitis Optica Study Group, a nationwide network established 2008. It recruited patients with diagnosed according 2006 Wingerchuk criteria aquaporin-4...
Auto-antibodies against the paranodal proteins neurofascin-155 and contactin-1 have recently been described in patients with chronic inflammatory demyelinating polyradiculoneuropathy are associated a distinct clinical phenotype response to treatment. Contactin-associated protein 1 (Caspr, encoded by CNTNAP1 ) is that attached (CNTN1) but has not yet identified as sole antigen neuropathies. In present study, we screened cohort of 35 (age range 20–80, 10 female, 25 male) 22 Guillain-Barré...
Abstract Background New-generation cell-based assays have demonstrated a robust association of serum autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) optic neuritis, myelitis, and brainstem encephalitis, as well neuromyelitis optica (NMO)-like or acute-disseminated encephalomyelitis (ADEM)-like presentations. However, only limited data are yet available on cerebrospinal fluid (CSF) findings in MOG-IgG-associated (MOG-EM; also termed...
<h3>Importance</h3> Giant cell arteritis (GCA) is the most common systemic vasculitis in elderly individuals. Diagnosis confirmed by temporal artery (TA) biopsy, although biopsy results are often negative. Despite use of corticosteroids, disease may progress. Identification causal agents will improve outcomes. Biopsy-positive GCA associated with TA infection varicella-zoster virus (VZV). <h3>Objective</h3> To analyze VZV TAs patients clinically suspected whose were histopathologically...
Abstract Although trastuzumab (Herceptin) has substantially improved the overall survival of patients with mammary carcinomas, even initially well-responding tumors often become resistant. Because natural killer (NK) cell–mediated antibody-dependent cell-mediated cytotoxicity (ADCC) is thought to contribute therapeutic effects trastuzumab, we have established a cell culture system select for ADCC-resistant SK-OV-3 ovarian cancer and MCF7 carcinoma cells. Ovarian cells down-regulated HER2...
The role of mitogen-activated protein kinase (MAPK) pathways in TGF-beta-induced myofibroblast transdifferentiation human tenon fibroblasts (HTFs) was investigated to identify potential pharmacologic targets for the inhibition scarring after glaucoma surgery.TGF-beta-dependent activation Smad2, p38, and Erk-1/2 examined by Western blot analysis. mRNA expression collagen Ialpha1, fibronectin, marker alpha smooth muscle actin (alpha-SMA) analyzed real-time RT-PCR. alpha-SMA subcellular...
The family of NFAT (nuclear factor activated T-cells) transcription factors plays an important role in cytokine gene regulation. In peripheral T-cells NFATc1 and -c2 are predominantly expressed. Because different promoter poly(A) site usage as well alternative splicing events, is synthesized multiple isoforms. highly inducible NFATc1/A contains a relatively short C terminus, whereas the longer, constitutively expressed isoform NFATc1/C spans extra C-terminal peptide 246 amino acids....
Human brain microvascular endothelial cells forming the blood-brain barrier (BBB) release soluble vascular cell adhesion molecule-1 (sVCAM-1) under inflammatory conditions. Furthermore, sVCAM-1 serum levels in untreated patients with multiple sclerosis (MS) correlate a breakdown of BBB as measured by gadolinium-enhanced MRI. To date, it is unknown whether itself modulates permeability. Here, we provide evidence that human endothelium expresses integrin α-4/β-1, molecular binding partner...
We retrospectively evaluated predictors of conversion to multiple sclerosis (MS) in 357 children with isolated optic neuritis (ON) as a first demyelinating event who had median follow-up 4.0 years. Multiple Cox proportional-hazards regressions revealed abnormal cranial magnet resonance imaging (cMRI; hazard ratio [HR] = 5.94, 95% confidence interval [CI] 3.39-10.39, p < 0.001), presence cerebrospinal fluid immunoglobulin G oligoclonal bands (OCB; HR 3.69, CI 2.32-5.86, and age (HR 1.08 per...
Endothelial cells of blood vessels forming the interphase between systemic circulation and tissues are crucial for maintenance homeostasis organ-related functions. Recent experiments support organ-specific endothelial differentiation suggest differential gene expression patterns in cells. Here, we compared primary human cerebral (HCEC), which major constituents brain barrier (BBB), with umbilical vein (HUVEC) by using cDNA array analysis 375 genes. Under basal culture conditions, 35 genes...
A recent genome-wide association study reported five loci for which there was strong, but sub-genome-wide significant evidence with multiple sclerosis risk. The aim of this to evaluate the role these potential risk in a large and independent data set ≈ 20,000 subjects. We tested single nucleotide polymorphisms rs228614 (MANBA), rs630923 (CXCR5), rs2744148 (SOX8), rs180515 (RPS6KB1), rs6062314 (ZBTB46) total 8499 cases sclerosis, 8765 unrelated control subjects 958 trios European descent. In...
The majority of patients presenting with a first clinical symptom suggestive multiple sclerosis (MS) do not fulfill the MRI criteria for dissemination in space and time according to 2010 revision McDonald diagnostic MS are thus classified as clinically isolated syndrome (CIS). To re-evaluate utility cerebrospinal fluid (CSF) analysis context revised from 2010, we conducted retrospective multicenter study aimed at determining prevalence predictive value oligoclonal IgG bands (OCBs) CIS....
<h3>Objective:</h3> To assess the therapy-related risk of malignancies in mitoxantrone-treated patients with multiple sclerosis. <h3>Methods:</h3> This retrospective observational cohort study included all sclerosis seen at our department between 1994 and 2007. We collected follow-up information on medically confirmed malignancies, life status, cause death, as 2010. Malignancy rates were compared to German national cancer registry matched for sex, age, year occurrence. <h3>Results:</h3>...