A5033540298- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Immune cells in cancer
- Dermatology and Skin Diseases
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Psoriasis: Treatment and Pathogenesis
- Vitamin D Research Studies
- Macrophage Migration Inhibitory Factor
- Nuclear Receptors and Signaling
- Cell Image Analysis Techniques
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- IL-33, ST2, and ILC Pathways
- MicroRNA in disease regulation
- AI in cancer detection
- Phagocytosis and Immune Regulation
- Connective Tissue Growth Factor Research
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Radiomics and Machine Learning in Medical Imaging
- Urticaria and Related Conditions
- Gut microbiota and health
- GDF15 and Related Biomarkers
Queen's University Belfast
2013-2024
Ludwig-Maximilians-Universität München
2009-2014
LMU Klinikum
2013
Gold Skin Care Center
2011
University of Würzburg
2005-2011
University of Tübingen
2010
St Vincent's Hospital
2010
Goethe University Frankfurt
2010
Heidelberg University
2010
University Hospital Heidelberg
2010
QuPath is new bioimage analysis software designed to meet the growing need for a user-friendly, extensible, open-source solution digital pathology and whole slide image analysis. In addition offering comprehensive panel of tumor identification high-throughput biomarker evaluation tools, provides researchers with powerful batch-processing scripting functionality, an extensible platform which develop share algorithms analyze complex tissue images. Furthermore, QuPath's flexible design makes it...
In psoriasis, cytosolic DNA in keratinocytes triggers maturation of the cytokine IL-1β via AIM2 inflammasome.
We analysed incidence, predictors, histological features and specific treatment options of anti-tumour necrosis factor α (TNF-α) antibody-induced psoriasiform skin lesions in patients with inflammatory bowel diseases (IBD).Patients IBD were prospectively screened for anti-TNF-induced lesions. Patients genotyped IL23R IL12B variants. Skin examined infiltrating Th1 Th17 cells. severe treated the anti-interleukin (IL)-12/IL-23 p40 antibody ustekinumab.Among 434 anti-TNF-treated IBD, 21 (4.8%)...
Abstract QuPath is new bioimage analysis software designed to meet the growing need for a user-friendly, extensible, open-source solution digital pathology and whole slide image analysis. In addition offering comprehensive panel of tumor identification high-throughput biomarker evaluation tools, provides researchers with powerful batch-processing scripting functionality, an extensible platform which develop share algorithms analyze complex tissue images. Furthermore, QuPath’s flexible design...
Abstract The proinflammatory cytokine macrophage migration inhibitory factor (MIF) stimulates tumor cell proliferation, migration, and metastasis; promotes angiogenesis; suppresses p53-mediated apoptosis; inhibits antitumor immunity by largely unknown mechanisms. We here describe an overexpression of MIF in ovarian cancer that correlates with malignancy the presence ascites. Functionally, we find may contribute to immune escape carcinoma transcriptionally down-regulating NKG2D vitro vivo...
Abstract Purpose: Growth and differentiation factor (GDF)-15 is a member of the transforming growth (TGF)-β family. GDF-15 necessary for maintenance pregnancy but has also been linked to other physiologic pathologic conditions. Experimental Design: The expression in glioma cell lines was assessed by quantitative reverse transcriptase-PCR immunoblot. levels situ peripheral blood patients were examined immunohistochemistry enzyme-linked immunosorbent assay, respectively. effects short hairpin...
Aging results in deterioration of the immune system, which is associated with increased susceptibility to infection and impaired wound healing elderly. Phagocytosis an essential process both defence. As such, age-related impairments phagocytosis impact on health elderly population. Phagocytic efficiency peritoneal macrophages, bone marrow-derived macrophages marrow monocytes from young old mice was investigated. significantly by vitro vivo. However, did not exhibit phagocytosis, suggesting...
Background: Differentiation between septic and aseptic loosening of joint replacements is essential for successful revision surgery, but reliable markers the diagnosis low-grade infection are lacking. The present study was performed to assess intra-articular systemic levels antimicrobial peptides proinflammatory cytokines as diagnostic periprosthetic infection. Methods: Fifteen consecutive patients with staphylococcal infections twenty control total hip knee were included in this...
Antimicrobial peptides (AMPs) are strongly expressed in lesional skin psoriasis and play an important role as proinflammatory "alarmins" this chronic disease. Vitamin D analogs like calcipotriol have antipsoriatic effects might mediate effect by changing AMP expression. In study, keratinocytes psoriatic plaques showed decreased expression of the AMPs β-defensin (HBD) 2 HBD3 after topical treatment with calcipotriol. At same time, normalized cytokine milieu interleukin (IL)-17A, IL-17F IL-8...
Ageing is the principal risk factor for retinal degenerative diseases, which are commonest cause of blindness in developed countries. These conditions include age-related macular degeneration or diabetic retinopathy. Regulatory T cells play a vital role immunoregulation nervous system by limiting inflammation and tissue damage health disease. Because retina was long-considered an immunoprivileged site, precise contribution regulatory homeostasis diseases remains unknown.
Abstract Myelin regeneration (remyelination) is essential to prevent neurodegeneration in demyelinating diseases such as Multiple Sclerosis, however, its efficiency declines with age. Regulatory T cells (Treg) recently emerged critical players tissue regeneration, including remyelination. However, the effect of ageing on Treg-mediated regenerative processes poorly understood. Here, we show that expansion aged Treg does not rescue age-associated remyelination impairment due an intrinsically...
Abstract Although trastuzumab (Herceptin) has substantially improved the overall survival of patients with mammary carcinomas, even initially well-responding tumors often become resistant. Because natural killer (NK) cell–mediated antibody-dependent cell-mediated cytotoxicity (ADCC) is thought to contribute therapeutic effects trastuzumab, we have established a cell culture system select for ADCC-resistant SK-OV-3 ovarian cancer and MCF7 carcinoma cells. Ovarian cells down-regulated HER2...
Keloids are the result of excessive scar tissue formation. Besides their poor aesthetic appearance, keloids can be associated with severe clinical symptoms such as pain, itching, and rigidity. Unfortunately, most therapeutic approaches remain clinically unsatisfactory. Recently, injections botulinum toxin A (BTA) were proposed for treatment established in a trial. In this study, we aimed to verify effects intralesional BTA therapy-resistant using objective measurements. addition, underlying...
Epidermal keratinocytes produce and secrete antimicrobial peptides (AMPs) that subsequently form a chemical shield on the skin surface. Cathelicidins are one family of AMPs in with various further immune functions. Consequently, dysfunction these has been implicated pathogenesis inflammatory disease. In particular, cathelicidin LL-37 is overexpressed inflamed psoriasis, binds to extracellular self-DNA released from dying cells converts potent stimulus for plasmacytoid dendritic (pDCs)....
Due to its low digestibility in the small intestine, a major fraction of polyol isomalt reaches colon. However, little is known about effects on intestinal microflora. During two 4-week periods double-blind, placebo-controlled, cross-over design, nineteen healthy volunteers consumed controlled basal diet enriched with either 30g or sucrose daily. Stools were collected at end each test phase and various microbiological luminal markers analysed. Fermentation characteristics also investigated...
BACKGROUNDMacrophage inhibitory cytokine-1 (MIC-1) is a multifunctional cytokine produced in high amounts by placental tissue. Inhibiting trophoblast invasion and suppressing inflammation through inhibition of macrophage activation, MIC-1 thought to provide pleiotropic functions the establishment maintenance pregnancy. So far, little known about decidual cell subsets producing effect this on dendritic cells (DCs), which are play distinct role development pro-fetal tolerance
The particular microenvironment of the skeletal muscle can be site complex immune reactions. Toll-like receptors (TLRs) mediate inflammatory stimuli from pathogens and endogenous danger signals link innate adaptive system. We investigated responses in human muscle. Analyzing TLR1-9 mRNA cultured myoblasts rhabdomyosarcoma cells, we found constitutive expression TLR3. TLR3 ligand Poly (I:C), a synthetic analog dsRNA, IFN-gamma increased levels. was mainly localized intracellularly regulated...
Antimicrobial peptides (AMPs) are effectors of cutaneous innate immunity and protect primarily against microbial infections. An array AMPs can be found in on the skin. Those include that were first discovered for their antimicrobial properties but also proteins with activity characterized as chemokines, enzymes, enzyme inhibitors neuropeptides. Cathelicidins among families They now known to exert a dual role immune defense: they have direct will initiate host cellular response resulting...
The microbiota is now recognized as a key influence on the host immune response in central nervous system (CNS). As such, there has been some progress toward therapies that modulate with aim of limiting immune-mediated demyelination, occurs multiple sclerosis. However, remyelination-the regeneration myelin sheaths-also depends upon an response, and effects such interventions might have remyelination not yet explored. Here, we show inflammatory during CNS mice modulated by antibiotic or...
Abstract Background Following allergen exposure, cytokines and other pro‐inflammatory signals play an important role in the immunological cascade leading to allergic sensitization. Inflammasomes sense exogenous endogenous danger trigger IL ‐1β ‐18 activation which turn shape Th2 responses. Honey bee venom ( BV ) allergies are very common; however, local inflammatory initiation of sensitization is poorly understood. In this study, cascades skin after exposure were investigated. Methods The...