A5089293571- Protease and Inhibitor Mechanisms
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Adhesion Molecules Research
- Neurogenesis and neuroplasticity mechanisms
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Platelet Disorders and Treatments
- Acute Lymphoblastic Leukemia research
- Angiogenesis and VEGF in Cancer
- Brain Metastases and Treatment
- Cancer Cells and Metastasis
- Synthesis of Tetrazole Derivatives
- Nicotinic Acetylcholine Receptors Study
- CAR-T cell therapy research
- Complement system in diseases
- Chronic Myeloid Leukemia Treatments
- Melanoma and MAPK Pathways
- Genetics, Aging, and Longevity in Model Organisms
- Cannabis and Cannabinoid Research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Extracellular vesicles in disease
- Vitamin D Research Studies
- Cancer, Hypoxia, and Metabolism
Instituto de Neurociencias
2022-2025
Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research
2013-2025
Consejo Superior de Investigaciones Científicas
2023
Abstract Myelin regeneration (remyelination) is essential to prevent neurodegeneration in demyelinating diseases such as Multiple Sclerosis, however, its efficiency declines with age. Regulatory T cells (Treg) recently emerged critical players tissue regeneration, including remyelination. However, the effect of ageing on Treg-mediated regenerative processes poorly understood. Here, we show that expansion aged Treg does not rescue age-associated remyelination impairment due an intrinsically...
Resistance of melanoma to targeted therapy and immunotherapy is linked metabolic rewiring. Here, we show that increased fatty acid oxidation (FAO) during prolonged BRAF inhibitor (BRAFi) treatment contributes acquired resistance in mice. Targeting FAO using the US Food Drug Administration-approved European Medicines Agency-approved anti-anginal drug ranolazine (RANO) delays tumour recurrence with BRAFi resistance. Single-cell RNA-sequencing analysis reveals RANO diminishes abundance...
Abstract Mixed-lineage leukemia (MLL)-rearranged (MLLr) infant B-cell acute lymphoblastic (iMLLr-B-ALL) has a dismal prognosis and is associated with pro-B/mixed phenotype, therapy refractoriness frequent central nervous system (CNS) disease/relapse. Neuron-glial antigen 2 (NG2) specifically expressed in MLLr leukemias used immunophenotyping because of its predictive value for leukemias. NG2 involved melanoma metastasis brain development; however, role MLL-mediated leukemogenesis remains...
The extracellular protease ADAMTS1 (A disintegrin and metalloprotease with thrombospondin repeats 1) has been described as an anti-angiogenic molecule its role a putative tumor protective also suggested. Here, we have used xenograft model to determine the of in growth angiogenesis. Increasing levels led complete inhibition growth. In attempt elucidate mechanism action this protease, focused our attention on proteolytic activity nidogens, one main components vascular basement membrane....
Melanoma is an aggressive form of skin cancer due to its high metastatic abilities and resistance therapies. cells reside in a heterogeneous tumour microenvironment that acts as crucial regulator progression. Snail1 epithelial-to-mesenchymal transition transcription factor expressed during development reactivated pathological situations including fibrosis cancer. In this work, we show activated the melanoma microenvironment, particularly fibroblasts. Analysis mouse models allow stromal...
Recent research highlighted the contribution of extracellular matrix, and particularly ADAMTS proteases, in immune regulation. Now, our work with melanoma mammary tumor models revealed that blockade induced by lack Adamts1 led to an increased vascular deposition its substrate, basement membrane glycoprotein NIDOGEN-1 (NID1). Significantly, overexpression NID1 syngeneic model also blocked progression, disclosing overlapping phenotype absence Adamts1. These tumors showed important alterations...
Recent advances have emphasized the relevance of studying extracellular microenvironment given its main contribution to tissue homeostasis and disease. Within this complex scenario, we studied protease ADAMTS1 (a disintegrin metalloprotease with thrombospondin motif 1), implicated in vascularization development, reported anti- pro-tumorigenic activities. In work performed a detailed study vasculature substrates adult organs wild type Adamts1-deficient mice. addition expected alterations like...
// Rubén Fernández-Rodríguez 1 , Francisco Javier Rodríguez-Baena Estefanía Martino-Echarri Carlos Peris-Torres María del Carmen Plaza-Calonge Juan Rodríguez-Manzaneque GENYO, Centre for Genomics and Oncological Research, Pfizer/Universidad de Granada/Junta Andalucía, Granada 18016, Spain Correspondence to: Rodríguez-Manzaneque, email: juancarlos.rodriguez@genyo.es Keywords: extracellular protease, matrix, hypoxia, tumor stroma, vasculature Received: February 24, 2016 Accepted: April 10,...
Abstract Myelin regeneration (remyelination) is essential to prevent neurodegeneration in demyelinating diseases such as Multiple Sclerosis, however, its efficiency declines with age. Regulatory T cells (Treg) recently emerged critical players tissue regeneration, including remyelination. However, the effect of ageing on Treg-mediated regenerative processes poorly understood. Here, we show that expansion aged Treg does not rescue age-associated remyelination impairment due an intrinsically...
Melanoma is one of the deadliest forms cancer. Most melanoma deaths are caused by distant metastases in several organs, especially brain, so-called brain (MBMs). However, precise mechanisms that sustain growth MBMs remain elusive. Recently, excitatory neurotransmitter glutamate has been proposed as a brain-specific, pro-tumorigenic signal for various types cancers, but how neuronal shuttling onto regulated remains unknown. Here, we show cannabinoid CB1 receptor (CB1R), master regulator...
Abstract Melanoma is an aggressive form of skin cancer due to its high metastatic abilities and resistance therapies. cells reside in a heterogeneous tumour microenvironment that acts as crucial regulator progression. Snail1 epithelial-to-mesenchymal transition transcription factor expressed during development reactivated pathological situations including fibrosis cancer. In this work, we show activated the melanoma microenvironment, particularly fibroblasts. Analysis murine models allow...