A5015885258- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Caveolin-1 and cellular processes
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Autophagy in Disease and Therapy
- Frailty in Older Adults
- Helicobacter pylori-related gastroenterology studies
- Nutrition and Health in Aging
- Histone Deacetylase Inhibitors Research
- ATP Synthase and ATPases Research
- Endoplasmic Reticulum Stress and Disease
- Protein Degradation and Inhibitors
- 14-3-3 protein interactions
- Genetics, Aging, and Longevity in Model Organisms
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Telomeres, Telomerase, and Senescence
- Renal and related cancers
- Extracellular vesicles in disease
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2017-2025
Biogipuzkoa Health Research Institute
2016-2025
Ikerbasque
2016-2025
Instituto de Salud Carlos III
2020-2025
Centre for Biomedical Network Research on Rare Diseases
2025
Centro de Investigación Biomédica en Red
2012-2024
University of Florida
2024
Donostiako Unibertsitate Ospitalea
2023
Cellular Biomedicine Group (United States)
2022
University of the Basque Country
2014-2022
Glioblastoma multiforme (GBM) is the most frequent malignant brain tumor in adults, and its prognosis remains dismal despite intensive research therapeutic advances. Diagnostic biomarkers would be clinically meaningful to allow for early detection of those cases which surgery contraindicated or biopsy results are inconclusive. Recent findings show that GBM cells release microvesicles contain a select subset cellular proteins RNA. The aim this hypothesis-generating study was assess diagnostic...
Breast cancer remains the most prevalent cause of mortality in woman worldwide due to metastatic process and therapy resistance. Resistance against is partially attributed stem cells (CSCs). These arise from epithelial undergoing epithelial-to-mesenchymal transition (EMT) might be responsible for tumor recurrence. In this study, we reported relevance miR-155 upregulation chemoresistant associated with EMT. Notably, found induction exosomes isolated CSCs resistant cells, followed by cells'...
Abstract SOX9 [sex-determining region Y (SRY)-box 9 protein], a high mobility group box transcription factor, plays critical roles during embryogenesis and its activity is required for development, differentiation, lineage commitment in various tissues including the intestinal epithelium. Here, we present functional clinical data of broadly important role tumorigenesis. was overexpressed wide range human cancers, where expression correlated with malignant character progression. Gain copy...
Despite the inarguable relevance of p53 in cancer, genome-wide studies relating endogenous activity to expression lncRNAs human cells are still missing. Here, by integrating RNA-seq with ChIP-seq analyses a cancer cell line under DNA damage, we define high-confidence set 18 that transcriptional targets. We demonstrate two p53-regulated required for efficient binding some its target genes, modulating network and contributing apoptosis induction damage. also show p53-lncRNAs is lowered...
The mechanisms responsible for the transcriptional silencing of pluripotency genes in differentiated cells are poorly understood. We have observed that lacking tumor suppressor p27 can be reprogrammed into induced pluripotent stem (iPSCs) absence ectopic Sox2. Interestingly, and tissues from null mice, including brain, lung, retina, present an elevated basal expression Sox2, suggesting contributes to repression Furthermore, iPSCs fail fully repress Sox2 upon differentiation. Mechanistically,...
Neural stem cells (NSCs) reside in specialized niches the adult mammalian brain, including subventricular zone and dentate gyrus, which act to control NSC behavior. Among other cell types within these niches, NSCs are found close proximity blood vessels. We carried out an analysis of interaction between endothelial NSCs, show that betacellulin (BTC), a member EGF family one several signaling molecules made by former, induces proliferation prevents spontaneous differentiation culture. When...
Background: SOX2 and SOX9 are commonly overexpressed in glioblastoma, regulate the activity of glioma stem cells (GSCs). Their specific overlapping roles GSCs treatment remain unclear.Methods: levels were examined human biopsies. Gain loss function determined impact altering on cell proliferation, senescence, activity, tumorigenesis chemoresistance.Results: expression correlates positively glioblastoma High bypass cellular senescence promote resistance to temozolomide. Mechanistic...
Abstract Gastric cancer remains one of the leading causes global mortality due to therapy resistance, with Helicobacter pylori (H. pylori) infection being a major risk factor. In this study, we report significance an elevation stem cell regulator SOX9 in bacteria-infected human gastritis and samples, paralleling increased levels TNFα. was more intense specimens containing pathogenically significant cagA+ strains H. pylori. Notably, found that required for bacteria-induced gastric...
The improvement of life quality and medical advances has resulted in increased expectancy. Despite this, health status commonly worsens the last years life. Frailty is an intermediate reversible state that often precedes dependency therefore, its identification may be essential to prevent dependency. However, there no consensus on best tools identify frailty. In this sense, diverse molecules have been proposed as potential biomarkers. Some investigations pointed chronic inflammation or...
Mammalian genes frequently present allelic variants that differ in their expression levels and that, the case of tumor suppressor genes, can be relevance for cancer susceptibility aging. We report here characterization a novel mouse model with increased activity Ink4a Arf suppressors. have generated “super Ink4a/Arf ” strain carrying transgenic copy entire locus. Cells derived from super mice resistance to vitro immortalization oncogenic transformation. Importantly, manifest higher compared...
The proteins encoded by the Ink4/Arf locus, p16Ink4a, p19Arf and p15Ink4b are major tumour suppressors that oppose aberrant mitogenic signals. expression levels of locus progressively increased during aging genome-wide association studies have linked to a number aging-associated diseases frailty in humans. However, direct measurement global impact on organismal longevity was lacking. In this work, we examined fertility, cancer susceptibility, mice genetically modified carry one (Ink4/Arf-tg)...
In developing amniote embryos, the first epithelial-to-mesenchymal transition (EMT) occurs at gastrulation, when a subset of epiblast cells moves to primitive streak and undergoes EMT internalize generate mesoderm endoderm. We show that in chick embryo this decision is mediated by reciprocal transcriptional repression Snail2 Sox3 factors. also relationship between Snail conserved mouse human cancer cells. embryo, Snail-expressing ingress streak, whereas Sox3-positive cells, which are unable...
Resistance of melanoma to targeted therapy and immunotherapy is linked metabolic rewiring. Here, we show that increased fatty acid oxidation (FAO) during prolonged BRAF inhibitor (BRAFi) treatment contributes acquired resistance in mice. Targeting FAO using the US Food Drug Administration-approved European Medicines Agency-approved anti-anginal drug ranolazine (RANO) delays tumour recurrence with BRAFi resistance. Single-cell RNA-sequencing analysis reveals RANO diminishes abundance...