Luís Bujanda
A5084259836- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Inflammatory Bowel Disease
- Gastric Cancer Management and Outcomes
- Microscopic Colitis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Pediatric Hepatobiliary Diseases and Treatments
- Diverticular Disease and Complications
- Pancreatic and Hepatic Oncology Research
- Liver Diseases and Immunity
- Cancer Genomics and Diagnostics
- Gastrointestinal disorders and treatments
- Colorectal Cancer Surgical Treatments
- Celiac Disease Research and Management
- RNA modifications and cancer
- Autoimmune and Inflammatory Disorders
- Veterinary medicine and infectious diseases
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
Biogipuzkoa Health Research Institute
2016-2025
University of the Basque Country
2016-2025
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2016-2025
Instituto de Salud Carlos III
2016-2025
Donostiako Unibertsitate Ospitalea
2013-2025
Ikerbasque
2013-2024
Centro de Investigación Biomédica en Red
2012-2024
Instituto de Ciencias de la Vid y del Vino
2019-2023
IRCCS Humanitas Research Hospital
2023
Universitat Autònoma de Barcelona
2013-2023
There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes 2019 (Covid-19). Genomewide association analysis may allow for identification of potential genetic factors involved development Covid-19.
Colonoscopy and fecal immunochemical testing (FIT) are accepted strategies for colorectal-cancer screening in the average-risk population.
OBJECTIVES: Changing patterns in medical practice may contribute to temporal changes the incidence of upper and lower gastrointestinal (GI) complications. There are limited data on GI complications clinical most studies that have been done serious methodological limitations inferring actual burden this problem. The aims study were analyze time trends hospitalizations resulting from originating both tract general population, determine risk factors, severity, impact these events. METHODS: This...
SOX2 (Sex-determining region Y (SRY)-Box2) has important functions during embryonic development and is involved in cancer stem cell (CSC) maintenance, which it impairs growth tumorigenicity. However, the function of pancreatic cells unclear. The objective this study was to analyze expression human tumors determine role regulating CSC properties. In report, we show that not expressed normal acinar or ductal cells. ectopic observed 19.3% tumors. knockdown results inhibition via cycle arrest...
After the withdrawal of some cyclooxygenase-2 (COX-2) selective inhibitors, traditional nonsteroidal anti-inflammatory drug (NSAID) use has increased, but without additional prevention strategies against upper gastrointestinal (GI) complications in many cases. Here, we report effect antisecretory drugs and nitrates on risk GI peptic ulcer bleeding (UGIB) associated with nonselective NSAIDs, aspirin, antiplatelet agents, anticoagulants.This case-control study matched 2,777 consecutive...
Cholangiocarcinoma (CCA) includes a heterogeneous group of biliary cancers with poor prognosis. Several conditions, such as primary sclerosing cholangitis (PSC), are risk factors. Noninvasive differential diagnosis between intrahepatic CCA and hepatocellular carcinoma (HCC) is sometimes difficult. Accurate noninvasive biomarkers for PSC, CCA, HCC not available. In the search novel biomarkers, serum extracellular vesicles (EV) were isolated from (n = 43), PSC 30), or 29) patients healthy...
Cl−/HCO Symbol anion exchanger 2 (AE2) participates in intracellular pH homeostasis and secretin-stimulated biliary bicarbonate secretion. AE2/SLC4A2 gene expression is reduced liver blood mononuclear cells from patients with primary cirrhosis (PBC). Our previous findings of hepatic immunological features mimicking PBC Ae2 -deficient mice strongly suggest that decreased AE2 might be involved the pathogenesis PBC. Here, we tested potential role microRNA 506 (miR-506) — predicted as candidate...
Cholangiocarcinoma (CCA) is a rare and heterogeneous biliary cancer, whose incidence related mortality increasing. This study investigates the clinical course of CCA subtypes (intrahepatic [iCCA], perihilar [pCCA], distal [dCCA]) in pan-European cohort.The ENSCCA Registry multicenter observational study. Patients were included if they had histologically proven diagnosis between 2010-2019. Demographic, histomorphological, biochemical, studies performed.Overall, 2,234 patients enrolled...
Macroautophagy is an evolutionarily conserved cellular process involved in the clearance of proteins and organelles. Although cytoplasmic machinery that orchestrates autophagy induction during starvation, hypoxia, or receptor stimulation has been widely studied, key epigenetic events initiate maintain remain unknown. Here we show methyltransferase G9a coordinates transcriptional activation regulators autophagosome formation by remodeling chromatin landscape. Pharmacological inhibition RNA...
The best approach for Helicobacter pylori management remains unclear. An audit process is essential to ensure clinical practice aligned with standards of care.International multicentre prospective non-interventional registry starting in 2013 aimed evaluate the decisions and outcomes H. by European gastroenterologists. Patients were registered an e-CRF AEG-REDCap. Variables included demographics, previous eradication attempts, prescribed treatment, adverse events outcomes. Data monitoring was...
Abstract Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS independent cohorts. conducted genome-wide association study 53,400 433,201 controls replicated significant associations in 23andMe panel (205,252 1,384,055 controls). Our confirmed six genetic loci IBS. Implicated...
BackgroundFibromyalgia is a complex, relatively unknown disease characterised by chronic, widespread musculoskeletal pain. The gut-brain axis connects the gut microbiome with brain through enteric nervous system (ENS); its disruption has been associated psychiatric and gastrointestinal disorders. To gain an insight into pathogenesis of fibromyalgia identify diagnostic biomarkers, we combined different omics techniques to analyse serum composition.MethodsWe collected faeces blood samples...
INTRODUCTION: Antibiotic resistance is one of the main factors that determine efficacy treatments to eradicate Helicobacter pylori infection. Our aim was evaluate effectiveness first-line and rescue against H. in Europe according antibiotics resistance. METHODS: Prospective, multicenter, international registry on management (European Registry Management). All infected culture-diagnosed adult patients registered Spanish Association Gastroenterology-Research Electronic Data Capture from 2013...
The prevalence of nonalcoholic fatty liver disease (NAFLD) is high. NAFLD linked to obesity, diabetes mellitus, and hypertriglyceridemia. Approximately 20% patients with will eventually develop cirrhosis. Our purpose was investigate whether resveratrol decreased hepatic steatosis in an animal model steatosis, this therapeutic approach resulted a decrease tumor necrosis factor α (TNF-α) production, lipid peroxidation oxidative stress. Male Wistar CRL: Wi (Han) (225 g) rats were randomized...
Early-onset colorectal cancer (CRC) represents a clinically distinct form of CRC that is often associated with poor prognosis. Methylation levels genomic repeats such as LINE-1 elements have been recognized independent factors for increased cancer-related mortality. The methylation status in early-onset has not analyzed previously.We 343 tissues and 32 normal colonic mucosa samples, including 2 cohorts diagnosed ≤ 50 years old (n=188), group sporadic >50 (MSS n=89; MSI n=46), Lynch syndrome...
Abstract SOX9 [sex-determining region Y (SRY)-box 9 protein], a high mobility group box transcription factor, plays critical roles during embryogenesis and its activity is required for development, differentiation, lineage commitment in various tissues including the intestinal epithelium. Here, we present functional clinical data of broadly important role tumorigenesis. was overexpressed wide range human cancers, where expression correlated with malignant character progression. Gain copy...