Alessandro Protti
A5014018414- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- COVID-19 Clinical Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nuclear Materials and Properties
- Long-Term Effects of COVID-19
- Metabolism, Diabetes, and Cancer
- Neonatal Respiratory Health Research
- Renal function and acid-base balance
- Radioactive element chemistry and processing
- Biomarkers in Disease Mechanisms
- Diabetes Treatment and Management
- Airway Management and Intubation Techniques
- Hemodynamic Monitoring and Therapy
- Pneumothorax, Barotrauma, Emphysema
- Pancreatic function and diabetes
- Thermal Regulation in Medicine
- Heart Failure Treatment and Management
- Family and Patient Care in Intensive Care Units
- Electrolyte and hormonal disorders
- Mitochondrial Function and Pathology
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Humanitas University
2019-2025
IRCCS Humanitas Research Hospital
2021-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2022
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2012-2021
Institute of Mechanics of Materials and Geostructures
2021
Biogipuzkoa Health Research Institute
2020
Ospedale Maggiore
2009-2019
Committee on Publication Ethics
2019
Novem (Netherlands)
2019
University of Milan
2009-2017
In December 2019, a novel coronavirus (severe acute respiratory syndrome 2 [SARS-CoV-2]) emerged in China and has spread globally, creating pandemic. Information about the clinical characteristics of infected patients who require intensive care is limited.To characterize with disease 2019 (COVID-19) requiring treatment an unit (ICU) Lombardy region Italy.Retrospective case series 1591 consecutive laboratory-confirmed COVID-19 referred for ICU admission to coordinator center (Fondazione IRCCS...
There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes 2019 (Covid-19). Genomewide association analysis may allow for identification of potential genetic factors involved development Covid-19.
Rationale: Unphysiologic strain (the ratio between tidal volume and functional residual capacity) stress transpulmonary pressure) can cause ventilator-induced lung damage.Objectives: To identify a strain–stress threshold (if any) above which damage occur.Methods: Twenty-nine healthy pigs were mechanically ventilated for 54 hours with producing 0.45 3.30. Ventilator-induced was defined as net increase in weight.Measurements Main Results: Initial weight capacity measured computed tomography....
Objective: Tidal volume (VT) and of gas caused by positive end-expiratory pressure (VPEEP) generate dynamic static lung strains, respectively. Our aim was to clarify whether different combinations resulting in the same large global strain, constantly produce edema. Design: Laboratory investigation. Setting: Animal unit. Subjects: Twenty-eight healthy pigs. Interventions: After computed tomography, 20 animals were ventilated for 54 hours at a strain 2.5, either entirely (VT 100% VPEEP 0%),...
Abstract Background Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim this study is to investigate and effect population during first 2020 pandemic wave. Methods Retrospective, multicentre, national cohort conducted between February 24 June 14, 2020, Italian Intensive Care Units (ICU) adult needing invasive mechanical ventilation for respiratory failure caused by COVID-19. Clinical were collected...
Lungs behave as viscoelastic polymers. Harms of mechanical ventilation could then depend on not only amplitude (strain) but also velocity (strain rate) lung deformation. Herein, we tested this hypothesis.Laboratory investigation.Animal unit.Thirty healthy piglets.Two groups animals were ventilated for 54 hours with matched strains (ratio between tidal volume and functional residual capacity) different strain rates inspiratory time). Individual ranged 0.6 3.5 in both groups. Piglets low had...
There is no consensus on the management of anticoagulation during extracorporeal membrane oxygenation (ECMO). ECMO currently burdened by a high rate hemostatic complications, possibly associated with inadequate monitoring heparin anticoagulation. This study aims to assess safety and feasibility an protocol for patients undergoing based thromboelastography (TEG) as opposed activated partial thromboplastin time (aPTT)-based protocol.We performed multicenter, randomized, controlled trial in two...
Objective. The relationship between metformin accumulation and lactate increase is still debated. This observational case series aims to evaluate the correlation of plasma levels with pH, creatinine levels, mortality rate in selected patients confirmed through concentration detection at hospital admission. Material methods. All cases lactic acidosis (pH, ≤ 7.35; arterial lactate, ≥ 5 mmol/L) related (plasma level 4 mcg/mL) from 2007 2011 were retrospectively reviewed. Erroneous ingestion...
We evaluate the clinical feasibility of spontaneous breathing on extracorporeal membrane oxygenation and interactions between artificial native lungs in patients bridged to lung transplant or with acute exacerbation chronic obstructive pulmonary disease (COPD) respiratory distress syndrome.The course a total 48 was analyzed. Twenty-three were enrolled prospective study (nine transplant, six COPD, eight syndrome). The response carbon dioxide removal evaluated terms rate esophageal pressure...
Importance Data on the association of COVID-19 vaccination with intensive care unit (ICU) admission and outcomes patients SARS-CoV-2–related pneumonia are scarce. Objective To evaluate whether is associated preventing ICU for to compare baseline characteristics vaccinated unvaccinated admitted an ICU. Design, Setting, Participants This retrospective cohort study regional data sets reports: (1) daily number administered vaccines (2) all consecutive in Lombardy, Italy, from August 1 December...
High tidal volume can cause ventilator-induced lung injury (VILI), but positive end-expiratory pressure (PEEP) is thought to be protective. We aimed find the volumetric VILI threshold and see whether PEEP protective per se or indirectly. In 76 pigs (22 ± 2 kg), we examined lower upper limits (30.9–59.7 mL/kg) of inspiratory capacity by computed tomography (CT) scan at 45 cmH2O pressure. The underwent a 54-h mechanical ventilation with global strain ((tidal (dynamic) + (static))/functional...
Abstract Background There is a lack of consensus on how to manage anticoagulation during veno-venous extracorporeal membrane oxygenation, including antithrombin monitoring and supplementation. The authors’ aim was determine current practice in large number oxygenation centers around the world. Methods This an electronic survey disseminated 2018 directors coordinators as well experts. Participating were classified according some covariates that may affect practice, 2017 gross national income...
ABSTRACT Background Respiratory failure is a key feature of severe Covid-19 and critical driver mortality, but for reasons poorly defined affects less than 10% SARS-CoV-2 infected patients. Methods We included 1,980 patients with respiratory at seven centers in the Italian Spanish epicenters pandemic Europe (Milan, Monza, Madrid, San Sebastian Barcelona) genome-wide association analysis. After quality control exclusion population outliers, 835 1,255 population-derived controls from Italy,...
Abstract Background Survivors of severe COVID-19 are at risk impaired health-related quality life (HRQoL) and persistent physical psychological disability after ICU hospital discharge. The subsequent social burden is a major concern. We aimed to assess the short-term HRQoL, function prevalence post-traumatic stress symptoms invasively mechanically ventilated patients treated in our ICU. Methods Prospective, observational cohort study follow-up clinic. Patients completed 6-min walking test...