A5038505861- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Trauma and Emergency Care Studies
- Intensive Care Unit Cognitive Disorders
- Cerebrovascular and Carotid Artery Diseases
- S100 Proteins and Annexins
- Acute Ischemic Stroke Management
- Traumatic Brain Injury Research
- Pituitary Gland Disorders and Treatments
- COVID-19 Clinical Research Studies
- Cardiac Arrest and Resuscitation
- Cerebral Venous Sinus Thrombosis
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Vascular Malformations Diagnosis and Treatment
- Anesthesia and Sedative Agents
- Neurological Complications and Syndromes
- Anesthesia and Pain Management
- Moyamoya disease diagnosis and treatment
- Optical Imaging and Spectroscopy Techniques
- Spine and Intervertebral Disc Pathology
Ospedale Papa Giovanni XXIII
2016-2025
University of Bergamo
2006-2024
Azienda Ospedaliera San Gerardo
2022
Intensive Care Foundation
2015
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2015
University Hospital of Bern
2015
Ospedale San Giovanni Bosco
2015
Aix-Marseille Université
2015
Sapienza University of Rome
2015
Centro Studi GISED
2015
In December 2019, a novel coronavirus (severe acute respiratory syndrome 2 [SARS-CoV-2]) emerged in China and has spread globally, creating pandemic. Information about the clinical characteristics of infected patients who require intensive care is limited.To characterize with disease 2019 (COVID-19) requiring treatment an unit (ICU) Lombardy region Italy.Retrospective case series 1591 consecutive laboratory-confirmed COVID-19 referred for ICU admission to coordinator center (Fondazione IRCCS...
Abstract Background Alternative noninvasive methods capable of excluding intracranial hypertension through use transcranial Doppler (ICP tcd ) in situations where invasive cannot be used or are not available would useful during the management acutely brain-injured patients. The objective this study was to determine whether ICP can considered a reliable screening test compared reference standard method, monitoring i ), presence hypertension. Methods This prospective, international,...
Importance Data on the association of COVID-19 vaccination with intensive care unit (ICU) admission and outcomes patients SARS-CoV-2–related pneumonia are scarce. Objective To evaluate whether is associated preventing ICU for to compare baseline characteristics vaccinated unvaccinated admitted an ICU. Design, Setting, Participants This retrospective cohort study regional data sets reports: (1) daily number administered vaccines (2) all consecutive in Lombardy, Italy, from August 1 December...
SARS-CoV-2 infection is associated with frequent thrombotic events, at the micro and macro-vascular level, due to perpetuation of a state hypercoagulability. The so-called 'COVID-19 coagulopathy' (CAC) represents key aspect in genesis organ damage from SARS-CoV-2. main coagulative alterations described literature are represented by high levels D-dimer fibrinogen. Although CAC has some common features disseminated intravascular coagulation sepsis-induced coagulopathy, there important...
Abstract Background The ultra-low-frequency pressure reactivity index (UL-PRx) has been established as a surrogate method for bedside estimation of cerebral autoregulation (CA). Although this shown to be predictor outcome in adult and pediatric patients with traumatic brain injury (TBI), comprehensive evaluation low sampling rate data collection (0.0033 Hz averaged over 5 min) on cerebrovascular never performed. Objective To evaluate the performance predictive power UL-PRx 12-month measures,...
Video-assisted thoracoscopic extended thymectomy (VATET) is well established in the treatment of myasthenia gravis; however, patient selection remains controversial. Perioperative management protocol lacking, and concerns regarding post-operative myasthenic crisis still remain. We performed a retrospective observational study evaluating impact introduction perioperative patients with gravis who underwent VATET.The was developed by team neurologists anesthesiologists reviewed literature their...
Acute kidney injury (AKI) is frequent in critically ill COVID-19 patients and associated with a higher mortality risk. By increasing intrathoracic pressure, positive pressure ventilation (PPV) may reduce renal perfusion by reducing venous return to the heart or congestion. This study's aim was evaluate association between AKI haemodynamic ventilatory parameters ARDS.
Abstract Background Post-traumatic cerebral infarction (PTCI) is common after traumatic brain injury (TBI). It unclear what the occurrence of a PTCI is, how it impacts long-term outcome, and whether adds incremental prognostic value to established outcome predictors. Methods This was prospective multicenter cohort study moderate severe TBI patients. The primary objective evaluate if an independent risk factor for 6-month assessed with Glasgow Outcome Scale (GOS). We also International...
To evaluate the frequency, types, and location of posttraumatic cerebral infarction, to assess if secondary insults were associated with determine infarction affected patients' outcome.We based diagnosis on review brain CT scans. We assessed frequency insults, including intracranial hypertension, hypoperfusion, systolic hypo- arterial blood oxygen desaturation, hypocapnia, hyperthermia, using clinical charts. used Glasgow Outcome Scale outcome at 6 months after trauma.Of 89 patients...
Older age is a well-known risk factor for unfavorable outcome in traumatic brain injury (TBI). However, many older people with TBI respond well to aggressive treatments, suggesting that chronological and severity alone may be inadequate prognostic markers. Frailty an age-related homeostatic imbalance of loss physiologic cognitive reserve resulting both limitation autonomy activities daily living vulnerability adverse events. We hypothesized frailty would associated 6-month functional...
Background: Although several studies of the use desflurane in anesthesia have revealed many desirable qualities, there are no data on and effects especially neuromuscular function myasthenia gravis (MG) patients. The purpose this study was to evaluate either or propofol, both combined with remifentanil, patients MG undergoing a video‐assisted thoracoscopic‐extended thymectomy (VATET). Methods: Thirty‐six who underwent VATET were enrolled. Nineteen anesthetized remifentanil propofol infused...
Traumatic brain injury (TBI) is a significant cause of death and disability, with no effective neuroprotective drugs currently available for its treatment. Mesenchymal stromal cell (MSC)-based therapy shows promise as MSCs release various soluble factors that can enhance the microenvironment through processes, such immunomodulation, neuroprotection, repair. Preclinical studies across different TBI models severities have demonstrated improve functional structural outcomes. Moreover, clinical...
A better understanding of the pathophysiology vasospasm-induced delayed cerebral ischemia and earlier detection hypoperfusion before ischemic injury are needed to guide therapy in subarachnoid hemorrhage (SAH). The cerebrovascular physiology major arterial territories differs from that watershed zones (WZs) a way would suggest differential topographic sensitivity brain vasospasm. primary end point study was investigate relation topography timing onset SAH.Forty-one patients were...