A5085991930- Clinical Nutrition and Gastroenterology
- Cardiac, Anesthesia and Surgical Outcomes
- Nutrition and Health in Aging
- Diet and metabolism studies
- Sepsis Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Abdominal Surgery and Complications
- COVID-19 Clinical Research Studies
- Enhanced Recovery After Surgery
- Hemodynamic Monitoring and Therapy
- Emergency and Acute Care Studies
- Muscle metabolism and nutrition
- Respiratory Support and Mechanisms
- Electrolyte and hormonal disorders
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Renal function and acid-base balance
- Cardiac Arrest and Resuscitation
- Colorectal Cancer Surgical Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Antimicrobial Resistance in Staphylococcus
- Healthcare Operations and Scheduling Optimization
- Silymarin and Mushroom Poisoning
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 and healthcare impacts
Integra (United States)
2024
Medico
2024
Aziende Socio Sanitarie Territoriale Ovest Milanese
2017-2023
Clinical Research Consortium
2023
ASST Melegnano e della Martesana
2023
Azienda Ospedaliera Ospedale Civile di Legnano
2006-2021
Regione Lombardia
2020
German BioImaging – Gesellschaft für Mikroskopie und Bildanalyse
2020
Mario Negri Institute for Pharmacological Research
2003-2006
Addenbrooke's Hospital
2006
In December 2019, a novel coronavirus (severe acute respiratory syndrome 2 [SARS-CoV-2]) emerged in China and has spread globally, creating pandemic. Information about the clinical characteristics of infected patients who require intensive care is limited.To characterize with disease 2019 (COVID-19) requiring treatment an unit (ICU) Lombardy region Italy.Retrospective case series 1591 consecutive laboratory-confirmed COVID-19 referred for ICU admission to coordinator center (Fondazione IRCCS...
Rationale: Treatment with noninvasive ventilation (NIV) in coronavirus disease (COVID-19) is frequent. Shortage of intensive care unit (ICU) beds led clinicians to deliver NIV also outside ICUs. Data about the use COVID-19 limited.Objectives: To describe prevalence and clinical characteristics patients treated investigate factors associated failure (need for intubation or death).Methods: In this prospective, single-day observational study, we enrolled adult who were ICU from 31 hospitals...
In patients with severe SARS-CoV-2 infection, the development of cytokine storm induces extensive lung damage, and monocytes play a role in this pathological process. Non-classical (NC) intermediate (INT) are known to be involved during viral bacterial infections. study, 30 different manifestations acute infection were investigated flow cytometric study NC, INT, classical (CL) monocytes. Significantly reduced NC INT downregulated HLA-DR found symptoms. Conversely moderate symptoms CD11b...
A Covid-19 outbreak developed in Lombardy, Veneto and Emilia-Romagna (Italy) at the end of February 2020. Fear an imminent saturation available ICU beds generated notion that rationing intensive care resources could have been necessary.In order to evaluate impact on capacity manage critically ill patients, we performed a retrospective analysis first 2 weeks (February 24-March 8). Data were collected from regional registries case report form sent participating sites. increased 1545 1989...
Patients with COVID-19 frequently exhibit a hypercoagulable state high thrombotic risk, particularly those admitted to intensive care units (ICU). Thromboprophylaxis is mandatory in these patients; nevertheless, thrombosis still occurs many cases. Thus, the problem of assessing an adequate level anticoagulation ICU patients becomes evident during pandemic. The aim this study was evaluate heparin resistance and efficacy monitoring using anti-Xa activity assay.Thirty-seven heparin-treated for...
Patients with severe COVID-19 disease frequently develop anaemia as the result of multiple mechanisms and often receive transfusions. The aims this study were to assess impact repeated blood samplings on patients' anaemic state using standard-volume tubes, in comparison hypothetical use low-volume tubes evaluate transfusion policy adopted.Transfusion data mechanically ventilated non-bleeding patients hospitalized ICU for a minimum 20 days recorded. total volume drawn corresponding red cell...
Glycaemia control (GC) remains an important therapeutic goal in critically ill patients. The enhanced Model Predictive Control (eMPC) algorithm, which models the behaviour of blood glucose (BG) and insulin sensitivity individual ICU patients with variable samples, is effective, clinically proven computer based protocol successfully tested at multiple institutions on medical surgical different nutritional protocols. eMPC has been integrated into B.Braun Space GlucoseControl system (SGC),...
Human nutrition is a broad, interdisciplinary cultural and scientific field, involving wide range of chemical, molecular, genetic, biochemical, physiological, psychological, cognitive-behavioral, statistical-epidemiological, clinical, technological, educational, economic, political social aspects. The high levels over- under-nutrition represent an important risk factor for mortality burden disease worldwide. It the opinion Federation Italian Nutrition Societies (FeSIN) that these two sides...
Long-lasting shared research databases are an important source of epidemiological information and can promote comparison between different healthcare services. Here we present PROSAFE, advanced international network in intensive care medicine, with the focus on assessing improving quality care. The project involved 343 ICUs seven countries. All patients admitted to ICU were eligible for data collection.The PROSAFE collected using same electronic case report form translated into corresponding...
The use of total parenteral nutrition after acute injury, either surgical or accidental, is widely accepted for its important benefits, although it not yet completely understood whether a reduction body protein catabolism can be effectively achieved. We applied to 14 critically ill patients trauma major surgery. Their daily nitrogen balance, urinary 3-methylhistidine and creatinine excretion, molar 3-methylhistidine/creatinine ratio, during initial 24-hr fasting period, were respectively...