Tommaso Zoerle
A5001469307- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma and Emergency Care Studies
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Sepsis Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- S100 Proteins and Annexins
- Intracerebral and Subarachnoid Hemorrhage Research
- Respiratory Support and Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Complement system in diseases
- Mesenchymal stem cell research
- Optical Imaging and Spectroscopy Techniques
- Cancer, Hypoxia, and Metabolism
- Spinal Fractures and Fixation Techniques
- Long-Term Effects of COVID-19
- Emergency and Acute Care Studies
- Vascular Malformations Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Nosocomial Infections in ICU
- Autopsy Techniques and Outcomes
- Functional Brain Connectivity Studies
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2016-2025
University of Milan
2008-2025
University of Groningen
2022
University Hospital Heidelberg
2021
University of Messina
2021
Heidelberg University
2021
Ospedale Maggiore
2012-2020
Oslo University Hospital
2020
St. Michael's Hospital
2012-2013
University of Toronto
2013
To describe mean intracranial pressure after aneurysmal subarachnoid hemorrhage, to identify clinical factors associated with increased pressure, and explore the relationship between outcome.Analysis of a prospectively collected observational database.Neuroscience ICU an academic hospital.One hundred sixteen patients hemorrhage monitoring.None.Episodes greater than 20 mm Hg lasting at least 5 minutes for every 12-hour interval were analyzed. The highest was analyzed in relation demographic...
Abstract Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and difficult to predict or treat. Thalamic functional integrity is particularly vulnerable in mTBI may be related long-term outcomes but requires further investigation. We compared structural MRI resting state 108 patients with a Glasgow Coma Scale (GCS) of 13–15 normal CT, 76 controls. examined whether acute changes thalamic connectivity were early markers for persistent explored neurochemical...
Abstract Background The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data available to provide optimal care in this scenario and worldwide variability clinical practice has been documented recent studies. Methods A multidisciplinary consensus panel physicians selected for their established scientific expertise the acute tSCI different specializations was established. World Society Emergency Surgery (WSES) European Association...
An impaired ability to regulate microglia activation by fractalkine (CX3CL1) leads chronic sub-activation. How this condition affects outcome after acute brain injury is still debated, with studies showing contrasting results depending on the timing and pathology. Here, we investigated early delayed consequences of receptor (CX3CR1) deletion neurological phenotypical features myeloid cells present in lesions mice traumatic (TBI). Wild type (WT) CX3CR1(-/-) C57Bl/6 were subjected sham or...
Monitoring cerebrovascular reactivity in adult traumatic brain injury (TBI) has been linked to global patient outcome. Three intra-cranial pressure (ICP)-derived indices have described. It is unknown which index superior for outcome association TBI outside previous single-center evaluations. The goal of this study evaluate 6- 12-month using uniform data harvested multiple centers. Using the prospectively collected from Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI)...
In this perspective, we discuss the potential of virtual reality (VR) in assessment and rehabilitation traumatic brain injury, a silent epidemic extremely high burden no pharmacological therapy available. VR, endorsed by mobile gaming industries, is now available more usable cheaper tools allowing its therapeutic engagement both at bedside during daily life chronic stages after injury with terrific for longitudinal disease modifying effect.
Background: Patient-specific epidemiologic intracranial pressure (ICP) thresholds in adult traumatic brain injury (TBI) have emerged, using the relationship between reactivity index (PRx) and ICP, displaying stronger association with outcome over existing guideline thresholds. The goal of this study was to explore a multi-center cohort order confirm previous finding. Methods: Using Collaborative European Neuro Trauma Effectiveness Research TBI (CENTER-TBI) high-resolution intensive care unit...
The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, are underrepresented TBI research. Therefore, we aimed to provide an overview health-care utilization, and six-month outcomes after their determinants who sustained TBI.We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI) study. In-hospital post-hospital care utilization were...
Impaired cerebrovascular reactivity in adult traumatic brain injury (TBI) is known to be associated with poor outcome. However, there has yet an analysis of the association between comprehensively assessed intracranial hypertension therapeutic intensity level (TIL) and reactivity. Using Collaborative European Neuro Trauma Effectiveness Research TBI (CENTER-TBI) high-resolution intensive care unit (ICU) cohort, we derived pressure index (PRx) as moving correlation coefficient slow-wave ICP...
To describe ICU stay, selected management aspects, and outcome of Intensive Care Unit (ICU) patients with traumatic brain injury (TBI) in Europe, to quantify variation across centers.This is a prospective observational multicenter study conducted 18 countries Europe Israel. Admission characteristics, clinical data, were described at patient- center levels. Between-center the total population was quantified median odds ratio (MOR), correction for case-mix random between centers.A 2138...
Traumatic brain injury (TBI) is a leading cause of death and long-term disability worldwide. In addition to primary damage, systemic immune alterations occur, with evidence for dysregulated responses in aggravating TBI outcome complications. However, dysfunction following has been only partially understood, especially the elderly who represent substantial proportion patients worst outcome. Therefore, we aimed conduct an in-depth immunological characterization patients, by evaluating both...
Severe traumatic brain-injured (TBI) patients should be primarily admitted to a hub trauma center (hospital with neurosurgical capabilities) allow immediate delivery of appropriate care in specialized environment. Sometimes, severe TBI are spoke hospital without capabilities), and scarce data available regarding the optimal management isolated who do not have access care.
<h3>Purpose</h3> The contribution of axonal injury to brain damage after aneurysmal subarachnoid haemorrhage (aSAH) is unknown. Neurofilament light chain (NF-L), a component the cytoskeleton, has been shown be elevated in cerebrospinal fluid patients with many types injury. We hypothesised that aSAH would have (CSF) NF-L levels and sought explore clinical correlates CSF dynamics. <h3>Methods</h3> Serial ventricular (vCSF) samples were collected from 35 for up 15 days. vCSF measurements...
Abstract Background After traumatic brain injury (TBI), fever is frequent. Brain temperature (BT), which directly linked to body temperature, may influence physiology. Increased and/or BT cause secondary damage, with deleterious effects on intracranial pressure (ICP), cerebral perfusion (CPP), and outcome. Methods Collaborative European NeuroTrauma Effectiveness Research in Traumatic Injury (CENTER-TBI), a prospective multicenter longitudinal study TBI Europe Israel, includes high resolution...
Patients with aneurysmal subarachnoid hemorrhage (SAH) frequently have deficits in learning and memory that may or not be associated detectable brain lesions. We examined mediators of long-term potentiation after SAH rats to determine what processes might involved. There was a reduction synapses the dendritic layer CA1 region on transmission electron microscopy as well reduced colocalization microtubule-associated protein 2 (MAP2) synaptophysin. Immunohistochemistry showed staining for GluR1...
Background: Aneurysmal Subarachnoid Haemorrhages (aSAH) are a severe condition often followed by vasospasm, causing several neurological and cognitive impairments in survivors. Nowadays there is still an open debate on actual impact of aSAH vasospasm over abilities time. This study aims at describing functioning focusing the acute phases after bleeding for 18 months, to investigate immediate long-term effects vasospasm. Methods: seventy adult patients have been prospectively recruited were...
To assess the involvement of ficolin-3, main initiator lectin complement pathway (LCP), in subarachnoid hemorrhage (SAH) pathology and outcome.In this preliminary exploratory study, plasma concentration ficolin-3 ficolin-3-mediated functional LCP activity was measured, along with that other initiators (mannose-binding lectin, ficolin-2, ficolin-1), C3 activation products, soluble C5b-9 terminal complex, a prospective cohort 39 patients SAH 20 healthy controls. The following parameters were...