A5032845158- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Burn Injury Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- BRCA gene mutations in cancer
- S100 Proteins and Annexins
- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Case Reports on Hematomas
- Clostridium difficile and Clostridium perfringens research
- Global Cancer Incidence and Screening
- Health Literacy and Information Accessibility
- Thermal Regulation in Medicine
- Cannabis and Cannabinoid Research
- Neurosurgical Procedures and Complications
- Surgical Simulation and Training
- Reconstructive Surgery and Microvascular Techniques
- Acute Ischemic Stroke Management
- Social Media in Health Education
- Diversity and Career in Medicine
- Disaster Response and Management
- Pressure Ulcer Prevention and Management
- Nitric Oxide and Endothelin Effects
- Connective tissue disorders research
University of Toronto
2012-2023
Health Sciences Centre
2021-2022
Sunnybrook Health Science Centre
2021-2022
St. Michael's Hospital
2013-2021
Neurological Surgery
2021
Background: Infection is the most common complication and cause of death in patients suffering burn injuries. These are susceptible to infection wound sepsis secondary alterations their physiology. Diagnosis management infections rely on physical examination, cultures, pathology wound. Method: We performed an electronic search for articles Google Scholar PubMed databases using terms "burn sepsis," infection," critical care." Results: Multiple factors increase patients' risk invasive sepsis,...
Delayed complications of subarachnoid hemorrhage (SAH) such as angiographic vasospasm, cortical spreading ischemia, microcirculatory dysfunction, and microthrombosis are reported in both patients animal models SAH. We demonstrated previously that SAH is associated with increased oxidative stress the brain parenchyma, this correlates dysfunction endothelial nitric oxide synthase (eNOS) (homodimeric uncoupling). Uncoupling eNOS exacerbated enhanced (NO) depletion, was multiple secondary...
Brain injury after intracerebral hemorrhage (ICH) occurs in cortex and white matter may be mediated by blood breakdown products, including hemoglobin heme. Effects of bilirubin oxidation have not been widely investigated adult brain. Here, we first determined the effect its products on structure function vitro using brain slices. Subsequently, whether these compounds an vivo. In all, 0.5 mmol/L treatment significantly damaged both myelinated axons but unmyelinated Toxicity was prevented...
Abstract Achondroplasia is an autosomal dominant condition resulting in skeletal dysplasia and abnormal endochondral bone formation. Many clinical features, including short stature, macroglossia, midface retrusion, restrictive lung disease, may pose anesthetic surgical risks. We present a case of 36-year-old female with right inflammatory breast cancer who underwent immediate autologous reconstruction deep inferior epigastric perforator flap complicated by hypoxic respiratory failure. review...
Patients with aneurysmal subarachnoid hemorrhage (SAH) frequently have deficits in learning and memory that may or not be associated detectable brain lesions. We examined mediators of long-term potentiation after SAH rats to determine what processes might involved. There was a reduction synapses the dendritic layer CA1 region on transmission electron microscopy as well reduced colocalization microtubule-associated protein 2 (MAP2) synaptophysin. Immunohistochemistry showed staining for GluR1...
Outcome varies among patients with subarachnoid hemorrhage but known prognostic factors explain only a small portion of the variation in outcome. We hypothesized that individual genetic variations influence brain and vascular responses to investigated this using inbred strains mice.Subarachnoid was induced seven chromosome 7 substitution strain mouse. Cerebral blood flow, vasospasm middle cerebral artery, injury were assessed. After 48 h hemorrhage, mice showed significant artery correlated...
Abstract Subarachnoid haemorrhage (SAH) is a type of hemorrhagic stroke that associated with high morbidity and mortality. New effective treatments are needed to improve outcomes. The pathophysiology SAH complex includes early brain injury delayed cerebral ischemia, both which characterized by blood–brain barrier (BBB) impairment. We isolated endothelial cells (BECs) from mice subjected injection blood into the prechiasmatic cistern. used gene expression profiling identify 707 unique genes...
There are limited data on coordinated breast and gynecological risk-reduction surgery for high-risk patients in Canada. Therefore, this study aims to evaluate the patient demographics, surgical details, outcomes of prophylactic mastectomy (PM) with immediate reconstruction bilateral salpingo-oophorectomy (BSO) patients.We conducted a retrospective chart review at an academic center who concurrently underwent PM laparoscopic BSO over 7-year period (March 2010-February 2017) were identified.A...
Adequate health literacy is essential to navigate the healthcare system and has a major role in peri-operative care outcomes. Minimal information exists regarding surgeons’ understanding of literacy, clinical implications, awareness universal measures support. This study assessed Canadian perceptions patients’ their knowledge available supportive resources. We conducted cross-sectional using an electronic survey distributed surgeons at academic institutions. Data collected included...
Infection is a leading cause of death in burn patients and increasing antimicrobial resistance has made management difficult. Antibiograms are useful tool to guide empiric treatment infections, however, inappropriate prescribing may influence resistance. The objective this study describe trends antibiotic susceptibilities use Canadian population pre- (PrA) post-introduction (PoA) antibiograms. We performed retrospective review admitted an ABA-verified Burn Centre for two years (2013-2014)...
Abstract Introduction Infection is a leading cause of death in burn patients. With an increase resistance patterns, management these infections has become progressively difficult. Antibiograms, summary susceptibilities to bacteria given institution or area, are often used guide empiric treatment infections. However, inappropriate prescribing and use antimicrobials may greatly impact the incidence resistance. Currently, we do not know patterns antibiotic since introduction institutional...
Abstract Introduction Cannabis use has been associated with larger total burn size areas, longer hospital stays, and an increased number of operations. Legalization marijuana in Colorado led to marked increases injuries. Tetahydrocannabinol (‘THC’) shown increase psychosis, anxiety, depression, however, it is unknown how this impacted rates ICU related delirium the context. Further, observational studies have that decreased opioid-related overdoses, but chronic affects opioid consumption...
Introduction: The pathophysiology of subarachnoid hemorrhage (SAH) is complex and includes disruption the blood-brain barrier (BBB). We have previously optimized methods to freshly isolate BBB endothelial cells (BECs) performed genome-wide expression profiling uncover new therapeutic targets in an unbiased manner. In this study we validated 2 most highly upregulated targets, cyclooxygenase-2 (Cox2) angiopoietin-2 (Angpt2). Methods: prechiasmatic blood injection mouse model SAH was used with...
Introduction: The implementation of competency-based residency training in plastic surgery is underway. Key competencies have been previously identified, however, within the domain pediatrics, data suggest limited exposure throughout for Canadian graduates. This study aims to identify and involvement residents core pediatric cases. Methods: We performed a retrospective, multicenter review resident case logs (T-Res, POWER, New Innovations) across 10 Canadian, English-speaking programs between...
Abstract Introduction In September 2020, the American Burn Association released new pain guidelines following a rigorous literature review and input from experts. These were last updated 14 years ago represent multitude of changes including increased importance for non-opioid medication use non-pharmacologic adjuncts given current opioid crisis. Specifically, main recommendations to sparingly always with adjuncts; acetaminophen utilized in all patients; NSAID depending on baseline...