A5004101521- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Ion Channels and Receptors
- Voice and Speech Disorders
- Delphi Technique in Research
- Neuroendocrine regulation and behavior
- Childhood Cancer Survivors' Quality of Life
- Stress Responses and Cortisol
- Pediatric health and respiratory diseases
- Anorectal Disease Treatments and Outcomes
- Electronic Health Records Systems
- Breast Cancer Treatment Studies
- Biomedical Text Mining and Ontologies
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Pelvic floor disorders treatments
- Diverticular Disease and Complications
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences North
2020-2021
Queen's University
2014-2020
Kingston Health Sciences Centre
2018
Kingston General Hospital
2015-2017
University Hospital Schleswig-Holstein
2003
University of Lübeck
2003
Objectives: The burden of asthma ranks among the highest for chronic diseases. Interoperable electronic health records (EHRs) can improve management diseases such as by facilitating sharing data between care settings along continuum care. Terminology SNOMED CT® (Systematized Nomenclature Medicine-Clinical Terms) and LOINC® (Logistical Observation Identifier Names Codes) are prerequisites interoperability EHRs. We sought to determine extent which elements in a validated map (ACM) congruent...
The clinical relevance of cough during methacholine challenge in individuals with normal airway sensitivity is unknown. We compared responses chronic who high-dose bronchoprovocation and have versus increased to healthy controls. Fifteen participants (CONTROL) aged 26 ± 7 yr (mean SD) 32 42 14 suspected asthma completed testing. Three did not had were excluded. Spirometry lung volumes at the maximum response (MAX) among 1) ASTHMA [ n = 15, provocative concentration causing a 20% fall forced...
The pathophysiologic processes distinguishing classic asthma (CA), cough-variant (CVA), and methacholine (MCh)-induced cough but normal airway sensitivity (COUGH) are inadequately understood may be a result of differences in the ability to bronchodilate following deep inspiration (DI). purpose this study was compare bronchodilating effect DIs individuals with CA, CVA, COUGH using high-dose MCh. Individuals aged 18-65 yr CA or suspected CVA completed MCh testing maximum change forced...
The pathophysiologic differences between methacholine-induced cough but normal airway sensitivity (COUGH) and healthy individuals (CONTROL) are incompletely understood may be due to in the bronchodilating effect of deep inspirations (DIs). purpose this study is compare DIs with classic asthma (CA), variant (CVA), COUGH CONTROL assess impulse oscillometry (IOS) measures as predictors DIs.A total 43 adults [18 female; 44.8 ± 12.3 years (mean SD); n = 11 CA, 10 CVA, 7 COUGH, 15 CONTROL]...
Various specific neuroendocrine factors such as pituitary ACTH and adrenal corticosterone are crucial in the development of high blood pressure spontaneously hypertensive rats (SHR). Increasing evidence shows involvement central β-adrenergic receptors (β-ADR) regulation ACTH, aldosterone release. To further evaluate role β-ADR hypertension we investigated expression β1- β2-ADR hypothalamo-pituitary-adrenal (HPA) axis prehypertensive male SHR at mRNA protein levels using RT-PCR Western blot...