A5037434863- Pituitary Gland Disorders and Treatments
- Neurological disorders and treatments
- Glioma Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Meningioma and schwannoma management
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Neuroscience and Neural Engineering
- Cancer, Hypoxia, and Metabolism
- Traumatic Brain Injury and Neurovascular Disturbances
- EEG and Brain-Computer Interfaces
- Neuroendocrine Tumor Research Advances
- Genetic Neurodegenerative Diseases
- Cancer Treatment and Pharmacology
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Obsessive-Compulsive Spectrum Disorders
- Soil Management and Crop Yield
- Neuroblastoma Research and Treatments
- Adrenal Hormones and Disorders
- Functional Brain Connectivity Studies
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Agricultural and Food Sciences
- Immune cells in cancer
Ospedale Maggiore
2009-2025
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2016-2025
University of Milan
2014-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2002-2024
European Institute of Oncology
2009-2024
University of Parma
2022-2024
Ospedale Humanitas Gradenigo
2023
Jazz Pharmaceuticals (Italy)
2020-2022
Vita-Salute San Raffaele University
2001-2022
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2022
The aim of this study was to evaluate which clinical variables might influence the antiobsessional response proserotonergic drugs in a sample patients with obsessive-compulsive disorder (OCD). One hundred fifty-nine DSM-IV OCD underwent 12-week standardized treatment fluvoxamine, clomipramine, citalopram, or paroxetine. According response, defined as reduction Yale-Brown Obsessive Compulsive Scale total score >35%, were divided into two groups. Ninety (56.6%) responded and 69 (43.4%) did...
The orbitofrontal cortex (OFC) plays a major role in the pathophysiology of obsessive-compulsive disorder (OCD); functional neuroimaging studies indicate that OCD symptoms are associated with increased activity OFC, caudate nucleus, thalamus, and anterior cingulate gyrus. goal our single-blind study was to assess whether repetitive transcranial magnetic stimulation (rTMS) over left OFC would influence drug-resistant patients.Twenty-three consecutively admitted right-handed inpatients...
Emerging contaminants have been considered one of the main concerns for ensuring quality water around world.This work presents results 10 years analyses carried out in state São Paulo (Brazil) that has high population density and intense agricultural industrial activities.In this 58 compounds (9 hormones, 14 pharmaceuticals personal care products, 8 compounds, 17 pesticides illicit drugs) were determined from 2006 to 2015 708 samples including raw treated sewage, surface ground drinking...
The severity of coronavirus disease 2019 (COVID-19) is a crucial problem in patient treatment and outcome. aim this study to evaluate circulating level sphingosine-1-phosphate (S1P) along with markers, COVID-19 patients. One hundred eleven patients forty-seven healthy subjects were included. was found significantly associated anemia, lymphocytopenia, significant increase neutrophil-to-lymphocyte ratio, ferritin, fibrinogen, aminotransferases, lactate dehydrogenase (LDH), C-reactive protein...
Object. The authors investigated the effects of hyperoxia on brain tissue PO 2 and glucose metabolism in cerebral adipose after traumatic injury (TBI). Methods. After 3 hours ventilation with pure O , 18 tests were performed different days eight comatose patients TBI. Lactate, pyruvate, glucose, glutamate, measured extracellular fluid (ECF) by using microdialysis. Analytes also ECF abdominal tissue. increase fraction inspired rose from baseline value 32.7 ± to 122.6 45.2 mm Hg (p <...
Context: Transsphenoidal surgery is currently the primary therapeutic option for Cushing's disease. Despite considerable initial success, 10–30% of patients fail to achieve lasting remission. Evidence Acquisition: We evaluated a strategy immediate reoperation in surgical failures judged by plasma cortisol levels that did not fall 2 μg/dl or less within 72 h surgery. Of 215 with presumed ACTH microadenomas, treated between 1993 and 2004, 12 met inclusion criteria had prompt (within 15 d)...
Our objective was to describe the effects of surgery and radiotherapy on hormonal control tumor mass in short- long-term follow-up TSH-secreting pituitary adenomas (TSHomas).This a retrospective multicenter study.We collected data 70 TSHomas (70% macroadenomas). The mean 64.4 (range 3-324) months. Overall, 97% patients were treated with surgery; 27% them associated. After surgery, 75% normalized thyroid function, 58% both imaging profile, 9% developed deficiencies, 3% had or recurrence, all...
// Andrea Di Cristofori 1,2,* , Stefano Ferrero 3,4,* Irene Bertolini 1,3 Gabriella Gaudioso Maria Veronica Russo Valeria Berno 5 Marco Vanini 6 Locatelli 2 Mario Zavanone 1,2 Paolo Rampini Thomas Vaccari 7 Manuela Caroli and Valentina Vaira 3,5 1 Department of Pathophysiology Organ Transplantation, University Milan, Italy Division Neurosurgery, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, 3 Pathology, 4 Biomedical, Surgical Dental Sciences, Istituto Nazionale Genetica...
Background and Purpose— Cerebral cavernous malformation (CCM) is characterized by multiple lumen vascular malformations in the central nervous system that can cause neurological symptoms brain hemorrhages. About 20% of CCM patients have an inherited form disease with ubiquitous loss-of-function mutation any one 3 genes CCM1 , CCM2 CCM3 . The rest develop sporadic lesions histologically similar to those likely mediated a biallelic acquired vasculature. However, molecular phenotypic features...
Neuroimaging differentiation of glioblastoma, primary central nervous system lymphoma (PCNSL) and solitary brain metastasis (BM) remains challenging in specific cases showing similar appearances or atypical features. Overall, advanced MRI protocols have high diagnostic reliability, but their limited worldwide availability, coupled with the overlapping neuroimaging features among tumor subgroups, represent significant drawbacks entail disparities planning management these oncological...
Mutations of the Gsalpha gene inherited from mother lead to pseudohypoparathyroidism (PHP) type Ia (PHP Ia), in which Albright's hereditary osteodistrophy is associated resistance action different hormones, whereas same mutations father isolated [pseudo-PHP (PPHP)]. Accordingly, it has been suggested that under tissue-specific imprinting control, and recent studies provided evidence for a predominant maternal origin transcripts endocrine organs involved PHP phenotype. To establish whether...
Somatostatin analogs currently used in the treatment of acromegaly and other neuroendocrine tumors inhibit hormone secretion cell proliferation by binding to somatostatin receptor type (SST) 2 5. The antiproliferative pathways coupled these receptors have been only partially characterized. aim this study was evaluate effect octreotide super selective SST2 (BIM23120) SST5 (BIM23206) on apoptotic activity gene expression human somatotroph tumor cells. Eight expressing similar levels evaluated...