A5011114074- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Extracellular vesicles in disease
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Intracranial Aneurysms: Treatment and Complications
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Retinoids in leukemia and cellular processes
- Protein Degradation and Inhibitors
- Nutritional Studies and Diet
- Pleural and Pulmonary Diseases
- Acute Myeloid Leukemia Research
- Histone Deacetylase Inhibitors Research
- Mesenchymal stem cell research
- Digestive system and related health
- Ultrasound in Clinical Applications
- Barrier Structure and Function Studies
- Cancer Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
Casa Sollievo della Sofferenza
2017-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2017-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2017
Vita-Salute San Raffaele University
2017
IFOM
2013-2016
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2016
Mario Negri Institute for Pharmacological Research
2016
Uppsala University
2016
University of Milan
2015
Research Article26 November 2015Open Access Source Data KLF4 is a key determinant in the development and progression of cerebral cavernous malformations Roberto Cuttano IFOM, FIRC Institute Molecular Oncology, Milan, Italy Search for more papers by this author Noemi Rudini Luca Bravi Monica Corada Costanza Giampietro Department Biosciences, University Eleanna Papa on leave absence at Neurology, Laboratory Neuro-Oncology, Hospital Zurich, Switzerland Marco Francesco Morini Biomedicine, Basel,...
Significance Cerebral cavernous malformation (CCM) disease can lead to brain hemorrhages, seizures, and paralysis. No pharmacological therapy is currently available. Here we define, our knowledge for the first time in vivo, sequence of molecular events that CCM vascular cavernomas. We found β-catenin activation trigger followed by TGF-β signaling, which, turn, mediates progression disease. also show signaling cell-autonomous independent Wnt-receptor activation. Most importantly, these...
Background and Purpose— Cerebral cavernous malformation (CCM) is characterized by multiple lumen vascular malformations in the central nervous system that can cause neurological symptoms brain hemorrhages. About 20% of CCM patients have an inherited form disease with ubiquitous loss-of-function mutation any one 3 genes CCM1 , CCM2 CCM3 . The rest develop sporadic lesions histologically similar to those likely mediated a biallelic acquired vasculature. However, molecular phenotypic features...
Elucidating the molecular basis of tumor metastasis is pivotal for eradicating cancer-related mortality. Triple-negative breast cancer (TNBC) encompasses a class aggressive tumors characterized by high rates recurrence and metastasis, as well poor overall survival. Here, we find that promyelocytic leukemia protein PML exerts prometastatic function in TNBC can be targeted arsenic trioxide. We found that, patients, constitutive HIF1A activity induces expression PML, along with number target...
Abstract Acute promyelocytic leukemia ( APL ) is epitomized by the chromosomal translocation t(15;17) and resulting oncogenic fusion protein PML ‐ RAR α. Although acting primarily as a transcriptional repressor, α can also exert functions of co‐activation. Here, we find that stimulates transcription driven HIF factors, which are critical regulators adaptive responses to hypoxia stem cell maintenance. Consistently, ‐related gene signatures upregulated in leukemic promyelocytes from patients...
Abstract Lung cancer is the deadliest type worldwide with ~ 1.8 million deaths per-year. Smoking accounts for 85% of all cases, a described joint effect unhealthy diet in lung risk increase. Public health policies to prevent carcinogens exposure, promote smoking cessation and advocacy healthy nutrition, are therefore highly recommended. Here we have examined benefits Mediterranean Diet (MedDiet) protecting against some non-communicable diseases including cancer, highlighting epidemiological...
Lung cancer burden can be reduced by adopting primary and secondary prevention strategies such as anti-smoking campaigns low-dose CT screening for high risk subjects (aged >50 smokers >30 packs/year). Recent trials demonstrated a stage-shift towards earlier stage lung reduction of mortality (~20%). However, sizable fraction patients (30–50%) with early disease still experience relapse an adverse prognosis. Thus, the identification effective prognostic biomarkers in I is nowadays...
Background: Novel cancer biomarkers like microRNA (miRNA) are promising tools to gain a better understanding of lung pathology and yield important information guide therapy. In recent years, new less invasive methods for the diagnosis staging NSCLC have become key in thoracic oncology worldwide spread endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA). However, appropriate specimen handling is mandatory achieve adequate results reproducibility. The aim this single centre...
Abstract Locally advanced non-small cell lung cancer (NSCLC) is frequent at diagnosis and requires multimodal treatment approaches. Neoadjuvant chemotherapy (NACT) followed by surgery the of choice for operable locally NSCLC (Stage IIIA). However, majority patients are NACT-resistant show persistent lymph nodal metastases (LNmets) an adverse outcome. Therefore, identification mechanisms biomarkers NACT resistance paramount ameliorating prognosis with Stage IIIA NSCLC. Here, we investigated...
Brain microvasculature constitutes a highly specialized and selective vascular barrier between blood the central nervous system, called brain (BBB). In these vessels endothelial cells present developed system of tight junctions (TJs), absence fenestration low pinocytotic activity. Cells parenchyma, astrocytes, contribute to BBB-coverage with their foot processes, which constitute about eighty percent basal aspect vesselsThree proteins, CCM1, CCM2 CCM3, expressed by cells, are emerging as key...
Objectives We validated a screening protocol in which thoracic ultrasound (TUS) acts as first-line complementary imaging technique selecting patients may deserve second-line low-dose high resolution computed tomography (HRCT) scan among population of asymptomatic high-risk subjects for interstitial lung abnormalities (ILA) and cancer. Due to heavy environmental pollution burden, the district Tamburi Taranto has been chosen “case study” this purpose. Methods From July 2018 October 2020, 677...