A5087790193- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Moyamoya disease diagnosis and treatment
- Meningioma and schwannoma management
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Fetal and Pediatric Neurological Disorders
- Vascular Anomalies and Treatments
- Pituitary Gland Disorders and Treatments
- EEG and Brain-Computer Interfaces
- Pharmacological Effects and Toxicity Studies
- Glioma Diagnosis and Treatment
- Retinal and Macular Surgery
- Spinal Hematomas and Complications
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and genetic disorders
- Health Systems, Economic Evaluations, Quality of Life
University of Chicago
2016-2025
Neurological Surgery
2009-2025
University of Chicago Medical Center
2011-2025
Harvard University
2024
University of New Mexico
2008-2024
University of Arizona
2024
Massachusetts General Hospital
2021-2024
University of Hawaiʻi at Mānoa
2024
University of California, San Francisco
2009-2024
Neurelis (United States)
2024
✓ The incidence and natural history of the cavernous angioma have remained unclear in part because difficulty diagnosing following this lesion prior to surgical excision. introduction magnetic resonance (MR) imaging has improved sensitivity specificity vascular malformation. Seventy-six lesions with an MR appearance typical a presumed were discovered 66 patients among 14,035 consecutive images performed at Cleveland Clinic between 1984 1989. Follow-up studies 86% cases over mean period 26...
Patchy subcortical foci of increased signal intensity are frequently identified on magnetic resonance imaging (MRI) in the elderly. The incidence and clinical correlates these lesions remain unknown. In this report, 240 consecutive MRI scans performed over a 6-month period were reviewed (excluding patients with recent brain trauma or known demyelinating disease). Subcortical incidental (ILs) identified, which could not be accounted for by patient's current diagnosis, neurological status, CT...
The pathological correlates of subcortical lesions noted on magnetic resonance imaging (MRI) in the elderly are not known. Postmortem vitro proton MRI was performed brains seven consecutive patients dying nonneurologic causes. Scans were done fresh and fixed states with specimen immersed saline formaldehyde respectively. A 1.5 Tesla superconductive system used a multiple spin-echo protocol generating T2 weighted images. Subcortical localized three dimensions identified at brain cutting. In...
Delayed neurologic deterioration from vasospasm remains the greatest cause of morbidity and mortality following subarachnoid hemorrhage. The authors assess incidence clinical course symptomatic hemorrhage using a uniform management protocol over 24-month period. One hundred eighteen consecutive patients were admitted to neurovascular surgery service within 2 weeks not attributed trauma, tumor, or vascular malformation (113 had aneurysms). Early was performed whenever possible, hypertensive...
HomeStrokeVol. 31, No. 11Recommendations for the Management of Patients With Unruptured Intracranial Aneurysms
Background and Purpose— Perihematomal edema (PHE) can worsen outcomes after intracerebral hemorrhage (ICH). Reports suggest that blood degradation products lead to PHE. We hypothesized hematoma evacuation will reduce PHE volume treatment with recombinant tissue-type plasminogen activator (rt-PA) not exacerbate it. Methods— Minimally invasive surgery rt-PA in ICH (MISTIE) phase II tested safety efficacy of ICH. conducted a semiautomated, computerized volumetric analysis on computed tomography...
Endothelial cell–cell junctions regulate vascular permeability, vasculogenesis, and angiogenesis. Familial cerebral cavernous malformations (CCMs) in humans result from mutations of CCM2 (malcavernin, OSM, MGC4607), PDCD10 (CCM3), or KRIT1 (CCM1), a Rap1 effector which stabilizes endothelial junctions. Homozygous loss produces lethal phenotypes mice zebrafish. We report that the physical interaction proteins is required for junctional localization, lack either protein destabilizes barrier...
Patients who survive severe intracerebral hemorrhage (ICH) and intraventricular (IVH) typically have poor functional outcome in the short term understanding of future recovery is limited.To describe 1-year trajectories among ICH IVH survivors with initial disability assess association hospital events long-term recovery.This post hoc analysis pooled all individual patient data from Clot Lysis: Evaluating Accelerated Resolution Intraventricular Hemorrhage phase 3 trial (CLEAR-III) Minimally...
Cerebral cavernous malformation (CCM) is a Mendelian model of stroke, characterized by focal abnormalities in small intracranial blood vessels leading to hemorrhage and consequent strokes and/or seizures. A significant fraction cases inherited as an autosomal dominant trait with incomplete penetrance. Among Hispanic Americans, virtually all CCM attributable founder mutation localized 7q (CCM1). Recent analysis non-Hispanic Caucasian kindreds, however, has excluded linkage some, indicating at...
THE CLINICAL RELEVANCE of any scheme for classification vascular malformations the brain remains controversial. Widely accepted pathologic classifications include discrete venous, arteriovenous, capillary, and cavernous malformations. Of 280 cases possible evaluated by a single cerebrovascular service during 5-year period, 14 were instances mixed including definite features more than one pathologically type malformation within same lesion. There six venous in lesion; all instances, accounted...
HomeCirculationVol. 108, No. 10Coronary Risk Evaluation in Patients With Transient Ischemic Attack and Stroke