Barbara Gregson
A5043365502- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Geriatric Care and Nursing Homes
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury Research
- Cerebrospinal fluid and hydrocephalus
- Cerebrovascular and Carotid Artery Diseases
- Trauma and Emergency Care Studies
- Interprofessional Education and Collaboration
- Cardiac Arrest and Resuscitation
- Vascular Malformations Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Intergenerational Family Dynamics and Caregiving
- Healthcare Technology and Patient Monitoring
- Machine Learning in Healthcare
- Venous Thromboembolism Diagnosis and Management
- S100 Proteins and Annexins
- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Spinal Fractures and Fixation Techniques
- Breastfeeding Practices and Influences
- Primary Care and Health Outcomes
Newcastle University
2014-2024
Liverpool Heart and Chest Hospital
2024
Liverpool John Moores University
2024
University of Liverpool
2024
University of Alberta
2023
Utrecht University
2021
University Medical Center Utrecht
2021
New York Hospital Queens
2020
MIND Research Institute
2020
NewYork–Presbyterian Hospital
2020
BackgroundThe balance of risk and benefit from early neurosurgical intervention for conscious patients with superficial lobar intracerebral haemorrhage 10–100 mL no intraventricular admitted within 48 h ictus is unclear. We therefore tested the hypothesis that surgery compared initial conservative treatment could improve outcome in these patients.MethodsIn this international, parallel-group trial undertaken 78 centres 27 countries, we surgical haematoma evacuation 12 randomisation plus...
OBJECTIVE Symptomatic chronic subdural hematoma (CSDH) will become an increasingly common presentation in neurosurgical practice as the population ages, but quality evidence is still lacking to guide optimal management for these patients. The British Neurosurgical Trainee Research Collaborative (BNTRC) was established by trainees 2012 improve research combining efforts of each United Kingdom (UK) and Ireland's units (NSUs). authors present first study BNTRC that describes current outcomes...
Traumatic acute subdural hematomas frequently warrant surgical evacuation by means of a craniotomy (bone flap replaced) or decompressive craniectomy not replaced). Craniectomy may prevent intracranial hypertension, but whether it is associated with better outcomes unclear. Download PDF the Research Summary. We conducted trial in which patients undergoing surgery for traumatic hematoma were randomly assigned to undergo craniectomy. An inclusion criterion was bone an anteroposterior diameter...
Background and Purpose— Perihematomal edema (PHE) is associated with poor outcomes after intracerebral hemorrhage (ICH). PHE evolves in the early period ICH, providing a therapeutic target window for intervention. We studied effect of volume expansion first 72 hours (iPHE) its relationship functional outcomes. Methods— used data contained Virtual International Stroke Trials Archive. included patients who presented within 6 symptom onset, had baseline clinical, radiological, laboratory data,...
Abstract BACKGROUND Minimally invasive surgery procedures, including stereotactic catheter aspiration and clearance of intracerebral hemorrhage (ICH) with recombinant tissue plasminogen activator hold a promise to improve outcome supratentorial brain hemorrhage, morbid disabling type stroke. A recently completed Phase III randomized trial showed improved mortality but was neutral on the primary (modified Rankin scale score 0 3 at 1 yr). OBJECTIVE To assess surgical performance its impact...
Intraparenchymal hemorrhages occur in a proportion of severe traumatic brain injury TBI patients, but the role surgery their treatment is unclear. This international multi-center, patient-randomized, parallel-group trial compared early (hematoma evacuation within 12 h randomization) with initial conservative (subsequent allowed if deemed necessary). Patients were randomized using an independent randomization service 48 TBI. eligible they had no more than two intraparenchymal 10 mL or and did...
In previous studies, the Totaled Health Risks in Vascular Events (THRIVE) score has shown broad utility, allowing prediction of clinical outcome, death, and risk hemorrhage after tissue-type plasminogen activator (tPA) treatment, irrespective type acute stroke therapy applied to patient. We used data from Virtual International Stroke Trials Archive further validate THRIVE a large cohort patients receiving tPA or no confirm relationship between tPA, compare with several other available...
<h3>Importance</h3> Trials often assess primary outcomes of traumatic brain injury at 6 months. Longer-term data are needed to for patients receiving surgical vs medical treatment intracranial hypertension. <h3>Objective</h3> To evaluate 24-month with hypertension treated decompressive craniectomy or standard care. <h3>Design, Setting, and Participants</h3> Prespecified secondary analysis the Randomized Evaluation Surgery With Craniectomy Uncontrollable Elevation Intracranial Pressure...
Stroke has global importance and it causes an increasing amount of human suffering economic burden, but its management is far from optimal. The unsuccessful outcome several research programs highlights the need for reliable data on which to plan future clinical trials. Virtual International Trials Archive aims aid planning trials by collating providing access a rich resource patient perform exploratory analyses.Data were contributed principal investigators numerous past 16 years. These have...
Within the spectrum of spontaneous intracerebral haemorrhage there are some patients with large or space occupying who require surgery for neurological deterioration and others small haematomas should be managed conservatively. There is equipoise about management between these two extremes. In particular evidence that lobar no intraventricular might benefit from haematoma evacuation. The STICH II study will establish whether a policy earlier surgical evacuation in selected improve outcome...
Increased sympathetic drive after stroke is involved in the pathophysiology of several complications including poststroke immunudepression. β-Blocker (BB) therapy has been suggested to have neuroprotective properties and decrease infectious stroke. We aimed examine effects random pre- on-stroke BB exposure on mortality, functional outcome, occurrence pneumonia ischemic stroke.Data standard demographic clinical variables as well prestroke antihypertensive medication, incidence pneumonia,...