A5100656290- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Particle Detector Development and Performance
- Quantum Chromodynamics and Particle Interactions
- Acute Ischemic Stroke Management
- Dark Matter and Cosmic Phenomena
- Computational Physics and Python Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Neutrino Physics Research
- Multiple Myeloma Research and Treatments
- Cosmology and Gravitation Theories
- Heart Rate Variability and Autonomic Control
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Neurosurgical Procedures and Complications
- Cancer Treatment and Pharmacology
- Cerebrovascular and Carotid Artery Diseases
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Antiplatelet Therapy and Cardiovascular Diseases
- Intracranial Aneurysms: Treatment and Complications
- Obstructive Sleep Apnea Research
- Cardiovascular Syncope and Autonomic Disorders
- Distributed and Parallel Computing Systems
Hospital of the Brothers of St. John of God
2018-2025
Sigmund Freud University Vienna
2017-2025
Charles University
2019-2024
Northern Illinois University
2022-2024
Institute for High Energy Physics
2023-2024
Slovak Academy of Sciences
2023-2024
Centre of Experimental Medicine of the Slovak Academy of Sciences
2023-2024
Institute of Science and Technology
2023-2024
A. Alikhanyan National Laboratory
2024
Atlas Scientific (United States)
2024
Whether thrombectomy compared with best medical treatment (BMT) improves outcome in patients stroke and carotid artery dissection (CAD) is unknown. This was an international observational study based on prospective nationwide Austrian, German, Swiss registries. Patients large vessel occlusion (LVO) due to CAD were according modality (thrombectomy vs BMT including intravenous thrombolysis) admission severity NIH Stroke Scale (NIHSS) <6 NIHSS ≥6. The primary the favorable functional (modified...
Antiplatelets (APs) may increase the risk of symptomatic intracerebral hemorrhage (ICH) following intravenous thrombolysis after ischemic stroke.We assessed safety under APs in 11,865 patients compliant with European license criteria and recorded between 2002 2007 Safe Implementation Treatments Stroke (SITS) International Thrombolysis Register (SITS-ISTR). Outcome measures univariable multivariable analyses included ICH (SICH) per SITS Monitoring Study (SITS-MOST [deterioration National...
Objective: Impaired blood pressure regulation in the acute phase of stroke has been associated with less favorable outcome. Mechanisms and effects dysregulation are not well understood; however, central autonomic impairment sympathetic overactivity baroreflex involvement discussed. Baroreflex sensitivity (BRS) spontaneous intracerebral hemorrhage investigated. We sought to examine BRS patients evaluate relationship between short-term outcome measures. Design: An open, prospective study....
Although conceivably relevant for penumbra oxygenation, the optimal levels of hemoglobin (Hb) and hematocrit (Hct) in patients with acute ischemic stroke are unknown.We identified from our prospective local database who received intravenous thrombolysis based on multimodal magnet resonance imaging during years 1998 to 2009. A favorable outcome at 3 months was defined as a modified Rankin Scale score≤2 poor score≥3. The dynamics Hemoglobin (Hb), Hematocrit (Hct), other laboratory parameters...
Autonomic impairment after acute traumatic brain injury has been associated independently with both increased morbidity and mortality. Links between autonomic intracranial pressure or impaired cerebral autoregulation have described as well. However, relationships impairment, pressure, autoregulation, outcome remain poorly explored. Using continuous measurements of heart rate variability baroreflex sensitivity we aimed to test whether markers are functional mortality variables. Further,...
Increased sympathetic drive after stroke is involved in the pathophysiology of several complications including poststroke immunudepression. β-Blocker (BB) therapy has been suggested to have neuroprotective properties and decrease infectious stroke. We aimed examine effects random pre- on-stroke BB exposure on mortality, functional outcome, occurrence pneumonia ischemic stroke.Data standard demographic clinical variables as well prestroke antihypertensive medication, incidence pneumonia,...
It is unclear whether IV thrombolysis (IVT) outperforms early dual antiplatelet therapy (DAPT) in the acute setting of mild ischemic stroke. The aim this study was to compare safety and efficacy IVT with that DAPT.
Meta-analyses of case series non-arteritic central retinal artery occlusion (CRAO) indicate beneficial effects intravenous thrombolysis when initiated early after symptom onset. Randomized data are lacking to address this question.
Impairment of cerebrovascular autoregulation may promote secondary brain injury in acute insults. Until now, only limited data are available on patients with spontaneous intracerebral hemorrhage. In the current study, we aimed to investigate reactivity and its significance for outcome hemorrhage.We continuously recorded mean arterial pressure, intracranial cerebral perfusion pressure 95 hours 20 The moving correlation coefficient between (pressure index), an index vasoreactivity, was...
Background and Purpose— Impaired baroreflex sensitivity (BRS) has been previously shown to be of prognostic value in patients with cardiovascular disease stroke. Because seems blunted by both carotid atherosclerosis lesions affecting central processing, controversy exists regarding the etiology stroke-related changes. The insula may play a role modulation. aim study was therefore examine BRS acute stroke regard insular involvement. Methods— We evaluated spontaneous 96 within 72 hours ictus...
Abstract Introduction The impact of anemia on functional outcome and mortality in patients suffering from non-traumatic intracerebral hemorrhage (ICH) has not been investigated. Here, we assessed the relationship between hemoglobin (HB) levels clinical after ICH. Methods One hundred ninety six supratentorial, ICH were extracted our local stroke database (June 2004 to June 2006). Clinical radiologic computed tomography data, HB admission, mean values nadir during hospital stay recorded....
<h3>Background and Objectives</h3> COVID-19–related inflammation, endothelial dysfunction, coagulopathy may increase the bleeding risk lower efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate safety outcomes AIS COVID-19. <h3>Methods</h3> This was a retrospective multicenter cohort study consecutive receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 June 2021 tested for severe respiratory...
The relevance of blood pressure variability (BPV) in the development intracerebral hemorrhage (ICH) after intravenous thrombolysis (IVT) acute stroke still remains uncertain.427 consecutive patients treated with IVT years 2007-2009 were studied. Blood (BP) values analyzed from admission to follow-up imaging scan and described as mean, maximum, minimum, standard deviation (SD), difference between maximum successive variation (SV) SV. ICH was categorized based on radiologic criteria...
High infection rate after severe stroke may partly relate to brain-induced immunodepression syndrome. However, the underlying pathophysiology remains unclear. The aim of current study was investigate role autonomic shift in increased susceptibility acute intracerebral hemorrhage (ICH).We retrospectively analyzed 62 selected patients with ICH from our prospective database. Autonomic assessed using cross-correlational baroreflex sensitivity (BRS). occurrence and cause in-hospital infections...
It is unclear if a certain lipid profile and/or statin use contribute to symptomatic intracerebral haemorrhage (sICH), poor outcome or mortality after intravenous thrombolysis for ischaemic stroke. The aim of the current study was assess impact and on sICH, following in acute stroke.From 2001 2010, all patients admitted our hospital undergoing stroke were included into an open, prospective database. Initial severity assessed using National Institute Health Stroke Scale. Demographics,...
Abstract Introduction Current guidelines for spontaneous intracerebral hemorrhage (ICH) recommend maintaining cerebral perfusion pressure (CPP) between 50 and 70 mmHg, depending on the state of autoregulation. We continuously assessed dynamic autoregulation possibility determination an optimal CPP (CPPopt) in ICH patients. Associations autoregulation, CPPopt functional outcome were explored. Methods Intracranial (ICP), mean arterial (MAP) recorded 55 patients, with 38 patients included...
Symptomatic intracerebral hemorrhage (sICH) is the most feared acute complication after intravenous thrombolysis. The aim of this study was to determine predictive value parameters glycosylated hemoglobin A1 (HbA1c) on sICH.In a retrospective single center series, 1112 consecutive patients treated with thrombolysis were studied. Baseline blood glucose obtained at admission. HbA1c determined within hospital stay. A second head computed tomography 24 hours or when neurological worsening...
Abstract Background We have performed a head to comparison of all-oral triplet combination ixazomib, lenalidomide and dexamethasone (IRD) versus (RD) in patients with relapsed refractory multiple myeloma (RRMM) the routine clinical practice. Methods A total 344 treated IRD ( N = 127) or RD 217) were selected for analysis from Czech Registry Monoclonal Gammopathies (RMG). Descriptive statistics used assess patient’s characteristics associated respective therapy. The primary endpoint was...
The profile of patients with neurological diseases referred to specialized emergency rooms (ER) has not been reported and it is unknown whether a setting decentralized ERs associated high number referrals because inappropriate admissions.In this prospective study, consecutive ER were enrolled. Data encompassed time from symptom onset admission, discharge diagnoses, data on hospitalization transfers other ERs.Thousand seven hundred forty-three Most common diagnoses cerebrovascular events...
Objective Subcutaneous (SC) application of bortezomib has been recently introduced as a new route in multiple myeloma (MM) patients. We performed an analysis to compare the outcomes bortezomib-based therapy patients treated using either intravenous (IV) or subcutaneous administration. Patients and methods During January 2012 through December 2013, we retrospective 446 with MM regimens (either once weekly – 63% twice 27%) both, first line setting, relapse, separate undergoing autologous stem...