Brian Mac Grory
A5042517107- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Retinal and Optic Conditions
- Neurosurgical Procedures and Complications
- Cerebral Venous Sinus Thrombosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Neurological Disorders and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Renal and Vascular Pathologies
- Retinal Imaging and Analysis
- Long-Term Effects of COVID-19
- Congenital Heart Disease Studies
- S100 Proteins and Annexins
- Ocular Diseases and Behçet’s Syndrome
- Intraoperative Neuromonitoring and Anesthetic Effects
- Lipoproteins and Cardiovascular Health
- Cardiovascular and Diving-Related Complications
Duke University
2020-2025
Clinical Research Institute
2022-2025
Duke University Hospital
2024-2025
The University of Texas Southwestern Medical Center
2024
University of Virginia
2024
Brown University
2017-2024
Cornell University
2017-2024
Instituto Nacional de Neurología y Neurocirugía
2024
University of British Columbia
2024
National and Kapodistrian University of Athens
2022
With the spread of coronavirus disease 2019 (COVID-19) during current worldwide pandemic, there is mounting evidence that patients affected by illness may develop clinically significant coagulopathy with thromboembolic complications including ischemic stroke. However, limited data on clinical characteristics, stroke mechanism, and outcomes who have a COVID-19. We conducted retrospective cohort study consecutive were hospitalized between March 15, 2020, April 19, within major health system in...
Intracerebral hemorrhage (ICH) is a devastating form of stroke that results from the rupture blood vessel in brain, leading to mass within brain parenchyma. The injury causes rapid inflammatory reaction includes activation tissue-resident microglia and recruitment blood-derived macrophages other leukocytes. In this work, we investigated specific responses following ICH with aim identifying pathways may aid recovery after injury. We used longitudinal transcriptional profiling murine model...
A small randomized controlled trial suggested that dabigatran may be as effective warfarin in the treatment of cerebral venous thrombosis (CVT). We aimed to compare direct oral anticoagulants (DOACs) a real-world CVT cohort. This multicenter international retrospective study (United States, Europe, New Zealand) included consecutive patients with treated anticoagulation from January 2015 December 2020. abstracted demographics and risk factors, hypercoagulable labs, baseline imaging data,...
BACKGROUND: Rivaroxaban and dabigatran were not superior to aspirin in trials of patients with embolic stroke undetermined source (ESUS). It is unknown whether apixaban ESUS known risk factors for cardioembolism. METHODS: We conducted a multicenter, randomized, open-label, blinded-outcome trial (5 mg twice daily) compared (100 once initiated within 28 days after at least one predictive factor atrial fibrillation or patent foramen ovale. Cardiac monitoring was mandatory, treatment switched...
Intracerebral hemorrhage (ICH) is the deadliest stroke subtype, and mortality rates are especially high in anticoagulation-associated ICH. Recently, specific anticoagulation reversal strategies have been developed, but it not clear whether there a time-dependent treatment effect for door-to-treatment (DTT) times clinical practice.
Small, randomized trials of patients with cervical artery dissection showed conflicting results regarding optimal stroke prevention strategies. We aimed to compare outcomes in treated antiplatelets versus anticoagulation.
Background and Purpose- Left atrial enlargement has been shown to be associated with ischemic stroke, but the association embolic stroke mechanisms remains unknown. We aim study associations between left volume index (LAVI) subtypes fibrillation (AF) detection on cardiac event monitoring in patients of unknown source. Methods- Data were collected from a prospective cohort consecutive admitted comprehensive center over 18 months. Stroke subtype was classified into cardioembolic...
Background and Purpose- Despite treatment with oral anticoagulants, patients nonvalvular atrial fibrillation (AF) may experience ischemic cerebrovascular events. The aims of this case-control study in AF were to identify the pathogenesis risk factors for events occurring during non-vitamin K antagonist anticoagulants (NOACs) therapy stroke prevention. Methods- Cases consecutive who had acute NOAC treatment. Controls did not have NOACs Results- Overall, 713 cases (641 strokes 72 transient...
While the thrombotic complications of COVID-19 have been well described, there are limited data on clinically significant bleeding including hemorrhagic stroke. The clinical characteristics, underlying stroke mechanism, and outcomes in this particular subset patients especially salient as therapeutic anticoagulation becomes increasingly common treatment prevention COVID-19. We conducted a retrospective cohort study with (both non-traumatic intracerebral hemorrhage spontaneous non-aneurysmal...
In patients with atrial fibrillation who suffered an ischemic stroke while on treatment nonvitamin K antagonist oral anticoagulants, rates and determinants of recurrent events major bleedings remain uncertain.This prospective multicenter observational study aimed to estimate the bleeding their in follow-up consecutive acute cerebrovascular event anticoagulant treatment. Afterwards, we compared estimated risks between whom therapy was changed those continued original treatment.After a mean...
Background: Existing data and clinical trials could not determine whether faster intravenous thrombolytic therapy (IVT) translates into better long-term functional outcomes after acute ischemic stroke among those treated with endovascular thrombectomy (EVT). Patient-level national can provide the required large population to study associations between earlier IVT, versus later, longitudinal mortality in patients receiving IVT+EVT combined treatment. Methods: This cohort included older US...
Importance Understanding is needed of racial and ethnic–specific trends in care quality outcomes associated with the US nationwide initiative Target: Stroke (TS) targeting thrombolysis treatment for acute ischemic stroke. Objective To examine whether TS was improvement metrics across ethnic groups. Design, Setting, Participants This retrospective cohort study included patients who presented within 4.5 hours stroke onset at hospitals participating Get With The Guidelines–Stroke from January...
Background With the widespread use of direct oral anticoagulants (DOACs), there is an urgent need for a rapid assay to exclude clinically relevant plasma levels. Accurate and determination DOAC levels would guide medical decision-making (1) determine potential contribution spontaneous or trauma-induced hemorrhage; (2) identify appropriate candidates reversal, (3) optimize timing surgery intervention. Methods Results The Dipstick test uses disposable strip factor Xa- thrombin inhibitors in...
Importance Atrial fibrillation (AF) is the most common, chronic, cardiac arrythmia in older US adults. It not known whether AF independently associated with increased risk of retinal stroke (central artery occlusion), a subtype ischemic that causes severely disabling visual loss cases and harbinger further vascular events. Objective To determine there an association between stroke. Design, Setting, Participants This retrospective cohort study was performed July 2023 May 2024 using...
BACKGROUND: Established risk models may not be applicable to patients at higher cardiovascular with a measured Lp(a) (lipoprotein[a]) level, causal factor for atherosclerotic disease. METHODS: This was model development study. The data source the Nashville Biosciences set, which includes clinical from Vanderbilt University Health System. We included an between 1989 and 2022 who had least 1 year of electronic health record before measurement level. end point interest time first myocardial...
Background: The optimal endovascular management of cervical carotid dissection causing tandem occlusion remains uncertain. We investigated the impact emergent stenting during treatment (EVT) for acute ischemic stroke (AIS) in patients with secondary to artery dissection. Methods: This was a analysis treated EVT AIS due occlusive and included retrospective international Antithrombotic Treatment Stroke Prevention Cervical Artery Dissection (STOP-CAD) study. compared without stenting. primary...
Importance Tenecteplase is an alternative to alteplase for emergency treatment of acute ischemic stroke. However, limited data are available comparing their clinical effectiveness in routine practice. Objective To compare short-term and safety outcomes patients with stroke treated intravenous tenecteplase vs alteplase. Design, Setting, Participants This comparative study used prospectively collected from July 1, 2020, through June 30, 2022, the Get With The Guidelines–Stroke registry....
Background and Purpose— Elevated cardiac troponin is a marker of disease has been recently shown to be associated with embolic stroke risk. We hypothesize that early elevated levels in the acute setting are more prevalent patients subtypes (cardioembolic unknown source) as opposed noncardioembolic (large-vessel disease, small-vessel other). Methods— abstracted data from our prospective ischemic database included all during an 18-month period. Per laboratory, we defined positive ≥0.1 ng/mL...
Background There is limited data on predictors of symptomatic intracranial haemorrhage (sICH) in patients who underwent mechanical thrombectomy. In this study, we aim to determine those with external validation. Methods We evaluated thrombectomy a derivation cohort at comprehensive stroke centre over 30-month period. Clinical and radiographic these were obtained from the prospective quality improvement database. sICH was defined using European Cooperative Acute Stroke Study III. compared...
Background and purpose A subset of ischaemic stroke patients with atrial fibrillation (AF) have despite anticoagulation. We sought to determine the association between prestroke anticoagulant therapy recurrent events symptomatic intracranial haemorrhage (sICH). Methods included consecutive acute AF from Initiation Anticoagulation after Cardioembolic (IAC) study eight comprehensive centres in USA. compared delayed sICH risk using adjusted Cox regression analyses who were prescribed...