A5035289770- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Venous Thromboembolism Diagnosis and Management
- Cerebral Venous Sinus Thrombosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Atrial Fibrillation Management and Outcomes
- Stroke Rehabilitation and Recovery
- Peripheral Artery Disease Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Imaging and Diagnostics
- Epigenetics and DNA Methylation
- Neurological Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Reconstructive Surgery and Microvascular Techniques
- Biomedical Text Mining and Ontologies
- Medicinal Plant Pharmacodynamics Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cervical and Thoracic Myelopathy
- Cardiovascular Issues in Pregnancy
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- COVID-19 diagnosis using AI
Rhode Island Hospital
2021-2025
Brown University
1962-2025
Providence College
2021-2025
Miriam Hospital
2024-2025
Klinikum Ludwigshafen
2024
Boston University
2024
Boston Medical Center
2024
Yale University
2024
Medical University of South Carolina
2024
John Brown University
2021-2024
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share phenotypic pathologic overlap. Recently, an expansion of GGGGCC repeats in the first intron C9orf72 was found to be a common cause both illnesses; however, molecular pathogenesis this expanded repeat is unknown. Here we developed Drosophila mammalian models hexanucleotide showed that expression RNA (rGGGGCC) sufficient neurodegeneration. We further identified Pur α as RNA-binding protein rGGGGCC discovered interact...
Fat mass and obesity-associated gene (FTO) is a member of the Fe (II)- oxoglutarate-dependent AlkB dioxygenase family linked to both obesity intellectual disability. The role FTO in neurodevelopment neurogenesis, however, remains largely unknown. Here we show that expressed adult neural stem cells neurons displays dynamic expression during postnatal neurodevelopment. loss leads decreased brain size body weight. We find deficiency could reduce proliferation neuronal differentiation vivo,...
Sepsis is a leading cause of death in critical illness, and its pathophysiology varies depending on preexisting medical conditions. Here we identified nonalcoholic fatty liver disease (NAFLD) as an independent risk factor for sepsis large clinical cohort showed link between mortality NAFLD-associated hepatic mitochondrial energetic metabolism dysfunction. Using vivo vitro models lipid overload, discovered metabolic coordination hepatocyte mitochondria macrophages that express triggering...
A small randomized controlled trial suggested that dabigatran may be as effective warfarin in the treatment of cerebral venous thrombosis (CVT). We aimed to compare direct oral anticoagulants (DOACs) a real-world CVT cohort. This multicenter international retrospective study (United States, Europe, New Zealand) included consecutive patients with treated anticoagulation from January 2015 December 2020. abstracted demographics and risk factors, hypercoagulable labs, baseline imaging data,...
BACKGROUND: The optimal management of patients with isolated posterior cerebral artery occlusion is uncertain. We compared clinical outcomes for endovascular therapy (EVT) versus medical (MM) in occlusion. METHODS: This multinational case-control study conducted at 27 sites Europe and North America included consecutive presenting within 24 hours time last well from January 2015 to August 2022. Patients treated EVT or MM were multivariable logistic regression inverse probability treatment...
Small, randomized trials of patients with cervical artery dissection showed conflicting results regarding optimal stroke prevention strategies. We aimed to compare outcomes in treated antiplatelets versus anticoagulation.
There is uncertainty whether patients with large vessel occlusion (LVO) presenting in the late 6-hour to 24-hour time window can be selected for endovascular therapy (EVT) by noncontrast CT (NCCT) and angiography (CTA) LVO detection. We evaluated clinical outcomes of EVT NCCT compared those medically managed extended window.
Background and Purpose Posterior cerebral artery occlusion (PCAo) can cause long-term disability, yet randomized controlled trials to guide optimal reperfusion strategy are lacking. We compared the outcomes of PCAo patients treated with endovascular thrombectomy (EVT) or without intravenous thrombolysis (IVT) IVT alone.Methods From multicenter retrospective cerebraL ArTery Occlusion (PLATO) registry, we included isolated therapy within 24 hours onset between January 2015 August 2022. The...
Acute ischemic stroke with isolated posterior cerebral artery occlusion (iPCAO) lacks management evidence from randomized trials. We aimed to evaluate whether the association between endovascular treatment (EVT) and outcomes in iPCAO acute is modified by initial severity (baseline National Institutes of Health Stroke Scale [NIHSS]) arterial site.
Background: The optimal endovascular management of cervical carotid dissection causing tandem occlusion remains uncertain. We investigated the impact emergent stenting during treatment (EVT) for acute ischemic stroke (AIS) in patients with secondary to artery dissection. Methods: This was a analysis treated EVT AIS due occlusive and included retrospective international Antithrombotic Treatment Stroke Prevention Cervical Artery Dissection (STOP-CAD) study. compared without stenting. primary...
There is uncertainty about whether patients with an anterior circulation large vessel occlusion (LVO) and a low NIH Stroke Scale (NIHSS) score (≤5) benefit from endovascular therapy (EVT) in the late time window (6-24 hours). We compared clinical outcomes of these receiving EVT those medical management (MM). The CT for Late Endovascular Reperfusion multinational cohort study was conducted at 66 sites across 10 countries January 2014 to May 2022. This subanalysis included consecutive...
Children with multiple exposures to anesthesia and surgery may have an increased risk of developing cognitive impairment. Sevoflurane, a commonly used anesthetic in children, has been reported decrease levels postsynaptic density 95 protein. However, the upstream mechanisms downstream consequences sevoflurane-induced reduction protein remains largely unknown. We therefore set out assess whether sevoflurane acts on ubiquitination-proteasome pathway facilitate degradation.Six-day-old wild-type...
Background Wrist-worn accelerometry provides objective monitoring of upper-extremity functional use, such as reaching tasks, but also detects nonfunctional movements, leading to ambiguity in results. Objective Compare machine learning algorithms with standard methods (counts ratio) improve accuracy detecting activity. Methods Healthy controls and individuals stroke performed unstructured tasks a simulated community environment (Test duration = 26 ± 8 minutes) while video were synchronously...
Background We identified risk factors, derived and validated a prognostic score for poor neurological outcome death use in cerebral venous thrombosis (CVT). Methods performed an international multicenter retrospective study including consecutive patients with CVT from January 2015 to December 2020. Demographic, clinical, radiographic characteristics were collected. Univariable multivariable logistic regressions conducted determine factors outcome, mRS 3-6. A was validated. Results total of...
Previous studies have shown that Ogt-mediated O-GlcNAcylation is essential for neuronal development and function. However, the function of O-GlcNAc transferase (Ogt) in astrocytes remains largely unknown. Here we show Ogt deficiency induces inflammatory activation vivo vitro, impairs cognitive mice. The restoration via GlcNAc supplementation inhibits astrocytes, inflammation improves impaired deficient Mechanistically, interacts with NF-κB p65 catalyzes astrocytes. signaling pathway by...
Alzheimer's disease (AD) is the most common form of neurodegenerative disorder that leads to a decline in cognitive function. In AD, aggregates amyloid β peptide precede accumulation neurofibrillary tangles, both which are hallmarks disease. The great majority (>90 %) AD cases not originated from genetic defects, therefore supporting central roles epigenetic modifications acquired progressively during life span. Strong evidences have indicated implication modifications, including histone...
Background Developmental dysplasia of the hip (DDH) is a common orthopedic disease in children. In clinical surgery, it essential to quickly and accurately locate exact position lesion, there are still some controversies relating DDH status. We adopt artificial intelligence (AI) solve above problems. Methods this paper, automatic measurements classifications were achieved using three-stage pipeline. first stage, we used Mask-RCNN detect local features image segment bony pelvis, including...
Ischemic stroke is a serious complication of cardiac intervention, including surgery and percutaneous procedures. Endovascular thrombectomy (EVT) an effective treatment for ischemic may be particularly important intervention patients who often cannot receive intravenous thrombolysis. To examine trends in EVT during hospitalization with interventions vs those without the United States. This cohort study involved retrospective analysis using data 4888 US hospitals from 2016-2020 National...
With the expanding eligibility for endovascular therapy (EVT) of patients presenting in late window (6-24 hours after last known well), we aimed to derive a score predict favorable outcomes associated with EVT versus best medical management.
Importance One of 10 patients develop epilepsy in the late phase after cerebral venous thrombosis (CVT) diagnosis but predicting individual risk is difficult. Objective To and externally validate a prognostic score to estimate post-CVT epilepsy. Design, Setting, Participants This observational cohort study included both retrospective prospective enrolled from 1994 through 2022. For development DIAS 3 score, data International CVT Consortium (n = 1128), large international hospital-based...