Johannes Kaesmacher
A5020320620- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Peripheral Artery Disease Management
- Intracranial Aneurysms: Treatment and Complications
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebral Venous Sinus Thrombosis
- Neurosurgical Procedures and Complications
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Medical Imaging and Analysis
- Retinal and Optic Conditions
- Vascular Malformations Diagnosis and Treatment
- Neurological Disorders and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Glioma Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular and Diving-Related Complications
- Head and Neck Surgical Oncology
University of Bern
2017-2025
University Hospital of Bern
2017-2025
Centre Hospitalier Universitaire de Tours
2021-2025
Le Studium
2024-2025
Thion Medical (France)
2025
Clinical Investigation Center Plurithematic Tours
2024-2025
Centre d'Investigation Clinique - Innovation Technologique
2024-2025
Klinikum Ludwigshafen
2024
Boston University
2022-2024
Boston Medical Center
2022-2024
Advanced imaging for patient selection in mechanical thrombectomy is not widely available.To compare the clinical outcomes of patients selected by noncontrast computed tomography (CT) vs those perfusion (CTP) or magnetic resonance (MRI) extended time window.This multinational cohort study included consecutive with proximal anterior circulation occlusion stroke presenting within 6 to 24 hours last seen well from January 2014 December 2020. This was conducted at 15 sites across 5 countries...
Background The Thrombolysis in Cerebral Infarction (TICI) scale is the most widely applied scoring system to grade technical results of recanalizing therapies acute ischemic stroke (AIS). TICI 2b and 3 are conventionally subsumed as ‘successful recanalization’. Previous studies reported conflicting for clinical relevance achieving complete (TICI 3) versus ‘almost’ reperfusion 2b). Objective To examine if neurologic outcome differs significantly between patients with AIS middle cerebral...
Clinical evidence of the potential treatment benefit mechanical thrombectomy for posterior circulation distal, medium vessel occlusion (DMVO) is sparse.To investigate frequency as well clinical and safety outcomes isolated DMVO stroke to compare them with standard medical or without intravenous thrombolysis (IVT) in daily practice.This multicenter case-control study analyzed patients who were treated primary distal cerebral artery (PCA) P2 P3 segment. These received (with IVT) at 1 23...
Reperfusion without functional independence (RFI) is an undesired outcome following thrombectomy in acute ischemic stroke. The primary objective was to evaluate, patients presenting with proximal anterior circulation occlusion stroke the extended time window, whether selection computed tomography (CT) perfusion or magnetic resonance imaging associated RFI, mortality, symptomatic intracranial hemorrhage (sICH) compared noncontrast CT selected patients.The CLEAR study (CT for Late Endovascular...
International guidelines recommend avoiding intravenous thrombolysis (IVT) in patients with ischemic stroke who have a recent intake of direct oral anticoagulant (DOAC). To determine the risk symptomatic intracranial hemorrhage (sICH) associated use IVT DOAC ingestion. This international, multicenter, retrospective cohort study included 64 primary and comprehensive centers across Europe, Asia, Australia, New Zealand. Consecutive adult received (both without thrombectomy) were included....
BACKGROUND: The optimal management of patients with isolated posterior cerebral artery occlusion is uncertain. We compared clinical outcomes for endovascular therapy (EVT) versus medical (MM) in occlusion. METHODS: This multinational case-control study conducted at 27 sites Europe and North America included consecutive presenting within 24 hours time last well from January 2015 to August 2022. Patients treated EVT or MM were multivariable logistic regression inverse probability treatment...
BackgroundEndovascular treatment (EVT) of stroke with large-vessel occlusion is known to be safe and effective. The effect EVT for medium or distal vessels unclear.MethodsWe randomly assigned participants an isolated (occlusion the nondominant codominant M2 segment middle cerebral artery [MCA]; M3 M4 MCA; A1, A2, A3 anterior artery; P1, P2, P3 posterior artery) receive plus best medical alone within 24 hours after participant was last seen well. primary outcome level disability at 90 days,...
Importance Persisting or new thrombi in the distal arteries and microcirculation have been reported to limit benefits of successful endovascular thrombectomy for patients with acute ischemic stroke. It remains uncertain whether intra-arterial thrombolysis by urokinase following near-complete complete reperfusion improves outcomes among stroke due large vessel occlusion. Objective To assess efficacy adverse events after Design, Setting, Participants This investigator-initiated, randomized,...
<h3>BACKGROUND AND PURPOSE:</h3> Periprocedural thrombus fragmentation is a relevant risk in endovascular stroke treatment. Because factors influencing its occurrence are largely unknown, this study addresses potential relationship between histology and clot stability. <h3>MATERIALS METHODS:</h3> Eighty-five patients with anterior circulation treated thrombectomy were included retrospective study. The number location of emboli after retrieving the primary thrombus, maneuvers, TICI scores...
<b><i>Background:</i></b> Hemorrhagic transformation (HT) is a major complication of acute ischemic stroke, potentially associated with clinical deterioration. We attempted to identify risk factors and evaluated relevance minor HTs following endovascular thrombectomy (ET) in isolated middle cerebral artery (MCA) occlusions. <b><i>Methods:</i></b> This retrospective single-center analysis 409 patients MCA occlusion treated ET. Patients'...
Background Performing mechanical thrombectomy (MT) in patients with basilar artery occlusion (BAO) is currently not evidence-based. Objective To compare patients’ outcome, relative merits of achieving recanalization, and predictors futile recanalization (FR) between BAO anterior circulation large vessel (ACLVO) MT. Methods In the multicenter BEYOND-SWIFT registry ( NCT03496064 ), univariate multivariate (displayed as adjusted Odds Ratios, aOR 95% confidence intervals, 95%-CI) outcome...
Background and Purpose- If anterior circulation large vessel occlusion acute ischemic stroke patients presenting with ASPECTS 0-5 (Alberta Stroke Program Early CT Score) should be treated mechanical thrombectomy remains unclear. Purpose of this study was to report on the outcome provide data regarding effect successful reperfusion clinical outcomes safety measures in these patients. Methods- Multicenter, pooled analysis 7 institutional prospective registries: Bernese-European Registry for...
Our study proposed an automatic pipeline for opportunistic osteoporosis screening using 3D texture features and regional vBMD multi-detector CT images. A combination of different local global outperformed the showed high discriminative power to identify patients with vertebral fractures. Many at risk undergo computed tomography (CT) scans, usable (non-dedicated) screening. We compared performance volumetric bone mineral density (vBMD) a random forest classifier based on separate without...
The aim was to evaluate, in patients with atrial fibrillation (AF) and acute ischemic stroke, the association of prior anticoagulation vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) stroke severity, utilization intravenous thrombolysis (IVT), safety IVT, 3-month outcomes.This a cohort study consecutive (2014-2019) on versus those without (controls) regard rates IVT/mechanical thrombectomy, symptomatic intracranial hemorrhage (sICH), favorable outcome (modified Rankin...
Background and Purpose- Sustained successful reperfusion is an important prognostic factor for good clinical outcome in acute ischemic stroke. We aimed to identify the prevalence, impact, predictors of early reocclusion after initially thrombectomies within a prospective cohort. Methods- A total 711 stroke patients with (modified Thrombolysis Cerebral Infarction, 2b/3) followed magnetic resonance or computed tomographic angiography at 24 48 hours were included. Multivariable logistic...