A5070725191- Bone health and osteoporosis research
- Bone and Joint Diseases
- Medical Imaging and Analysis
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Osteoarthritis Treatment and Mechanisms
- Advanced MRI Techniques and Applications
- Heart Rate Variability and Autonomic Control
- Lower Extremity Biomechanics and Pathologies
- Hip and Femur Fractures
- Spine and Intervertebral Disc Pathology
- Dental Radiography and Imaging
- Receptor Mechanisms and Signaling
- Knee injuries and reconstruction techniques
- Spinal Fractures and Fixation Techniques
- Bone health and treatments
- Total Knee Arthroplasty Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- Eicosanoids and Hypertension Pharmacology
- Body Composition Measurement Techniques
- Adipose Tissue and Metabolism
- Bone Metabolism and Diseases
- Cardiovascular Disease and Adiposity
Klinikum rechts der Isar
2016-2025
Technical University of Munich
2016-2025
Praxis
2025
Society of Interventional Radiology
2019
Heliophysics
2018
University of California, San Francisco
2010-2016
Deutsche Forschungsgemeinschaft
2013-2016
European Research Council
2016
Creative Commons
2016
Philips (United States)
2016
Abstract The primary goal of this study was to assess peripheral bone microarchitecture and strength in postmenopausal women with type 2 diabetes fragility fractures (DMFx) compare them diabetics without (DM). Secondary goals were differences nondiabetic (Fx) (Co), DM Co women. Eighty (mean age 61.3 ± 5.7 years) recruited into these four groups (DMFx, DM, Fx, Co; n = 20 per group). Participants underwent dual-energy X-ray absorptiometry (DXA) high-resolution quantitative computed tomography...
ABSTRACT The goal of this magnetic resonance (MR) imaging study was to quantify vertebral bone marrow fat content and composition in diabetic nondiabetic postmenopausal women with fragility fractures compare them nonfracture controls without type 2 diabetes mellitus. Sixty-nine (mean age 63 ± 5 years) were recruited. Thirty-six patients (47.8%) had spinal and/or peripheral fractures. Seventeen fracture diabetic. Thirty-three (52.2%) controls. Sixteen To composition, underwent MR spectroscopy...
Published under a CC BY 4.0 license.
Abstract Purpose: To compare vertebral bone marrow fat content quantified with proton MR spectroscopy ( 1 H‐MRS) the volume of abdominal adipose tissue, lumbar spine volumetric mineral density (vBMD), and blood biomarkers in postmenopausal women without type 2 diabetes mellitus (T2DM). Materials Methods: Thirteen T2DM 13 age‐ body mass index‐matched healthy controls were included this study. All subjects underwent H‐MRS L1–L3 to quantify (FC) unsaturated lipid fraction (ULF). Quantitative...
To compare opportunistic quantitative CT (QCT) with dual energy X-ray absorptiometry (DXA) in their ability to predict incident vertebral fractures. We included 84 patients aged 50 years and older, who had routine including the lumbar spine DXA within a 12-month period (baseline) as well follow-up imaging after at least 12 months or sustained an fracture documented earlier. Patients bone disorders aside from osteoporosis were excluded. Fracture status trabecular mineral density (BMD)...
ObjectiveThe purpose of this study is to determine whether the mean and heterogeneity magnetic resonance (MR) knee cartilage T2 relaxation time measurements at baseline are associated with morphologic degeneration cartilage, meniscus, bone marrow tissues over 3 years in subjects risk factors for osteoarthritis (OA).DesignSubjects OA (n=289) an age range 45–55 were selected from Osteoarthritis Initiative (OAI) database. 3.0 Tesla MR images analyzed using morphological gradings menisci...
Purpose The purpose of the present study was to test relative performance chemical shift‐based water‐fat imaging in measuring bone marrow fat fraction presence trabecular bone, having as reference standard single‐voxel magnetic resonance spectroscopy (MRS). Methods Six‐echo gradient echo and MRS measurements were performed on proximal femur seven healthy volunteers. spectrum characterized based magnitude measurable peaks an a priori knowledge structure triglycerides, order accurately extract...
Standard DXA measurements, including Fracture Risk Assessment Tool (FRAX) scores, have shown limitations in assessing fracture risk Type 2 Diabetes (T2D), underscoring the need for novel biomarkers and suggesting that other pathomechanisms may drive diabetic bone fragility. MicroRNAs (miRNAs) are secreted into circulation from cells of various tissues proportional to local disease severity were recently found be crucial homeostasis T2D. Here, we studied, if which circulating miRNAs or...
The goals of this study were (i) to compare the prevalence focal knee abnormalities, mean cartilage T2 relaxation time, and spatial distribution magnetic resonance (MR) times between subjects with without risk factors for Osteoarthritis (OA), (ii) determine relationship MR parameters, age morphology as determined whole-organ imaging scores (WORMS) (iii) assess reproducibility WORMS scoring time measurements including grey level co-occurrence matrix (GLCM) texture parameters.Subjects OA (n =...
Abstract Purpose: To show the feasibility of assessing spatial distribution skeletal muscle adipose tissue using chemical shift‐based water/fat separation and to characterize differences in calf intermuscular (IMAT) compartmentalization patients with type 2 diabetes mellitus (T2DM) compared healthy age‐matched controls. Materials Methods: A approach a multiecho 3D spoiled gradient echo sequence was applied study 64 patients, including 35 controls 29 subjects T2DM. Masks were defined based on...
Our study proposed an automatic pipeline for opportunistic osteoporosis screening using 3D texture features and regional vBMD multi-detector CT images. A combination of different local global outperformed the showed high discriminative power to identify patients with vertebral fractures. Many at risk undergo computed tomography (CT) scans, usable (non-dedicated) screening. We compared performance volumetric bone mineral density (vBMD) a random forest classifier based on separate without...
To compare spinal bone measures derived from automatic and manual assessment in routine CT with dual energy X-ray absorptiometry (DXA) their association prevalent osteoporotic vertebral fractures using our fully automated framework ( https://anduin.bonescreen.de ) to assess various clinical CT.
Abstract With the advent of deep learning algorithms, fully automated radiological image analysis is within reach. In spine imaging, several atlas- and shape-based as well segmentation algorithms have been proposed, allowing for subsequent morphology pathology. The first “Large Scale Vertebrae Segmentation Challenge” (VerSe 2019) showed that these perform on normal anatomy, but fail in variants not frequently present training dataset. Building experience, we report largely increased VerSe...
Abstract Objectives To evaluate the performance of 3D T1w spoiled gradient-echo (T1SGRE) and ultra-short echo time (UTE) MRI sequences for detection assessment vertebral fractures degenerative bone changes compared with conventional CT. Methods Fractures ( n = 44) 60 spinal segments) were evaluated in 30 patients (65 ± 14 years, 18 women) on CT 3-T MRI, including CT-like images derived from T1SGRE UTE. Two radiologists morphological features both modalities: Genant AO/Magerl classifications,...
Migraine is a multifaceted primary headache disorder. In neuroimaging of migraine, fMRI has been used to elucidate pathophysiology or monitor treatment effects. The current literature, however, highly heterogeneous regarding reported variables and methodologies. This begets lack comparability complicates synthesis results across studies. We developed framework for standardized reporting studies in migraine. Experts on migraine were identified from the literature subjected structured...