A5077408401- Osteoarthritis Treatment and Mechanisms
- Bone and Joint Diseases
- Lower Extremity Biomechanics and Pathologies
- Total Knee Arthroplasty Outcomes
- Bone health and osteoporosis research
- Knee injuries and reconstruction techniques
- Rheumatoid Arthritis Research and Therapies
- Musculoskeletal synovial abnormalities and treatments
- Bone Metabolism and Diseases
- Diabetic Foot Ulcer Assessment and Management
- Radiomics and Machine Learning in Medical Imaging
- Traditional Chinese Medicine Studies
- Hip and Femur Fractures
- MicroRNA in disease regulation
- Medical Imaging Techniques and Applications
- Systemic Sclerosis and Related Diseases
- Orthopaedic implants and arthroplasty
- Advanced MRI Techniques and Applications
- Hip disorders and treatments
- Inflammatory mediators and NSAID effects
- Trace Elements in Health
- Advanced X-ray and CT Imaging
- Iron Metabolism and Disorders
- Spondyloarthritis Studies and Treatments
- Medical Imaging and Analysis
University of Freiburg
2021-2024
University of California, San Francisco
2014-2024
University Medical Center Freiburg
2023
University of Zurich
2020
University of California System
2014-2017
Laboratoire d’Imagerie Biomédicale
2016-2017
Technical University of Munich
2014
Ludwig-Maximilians-Universität München
2010
University of Regensburg
2006
Standard DXA measurements, including Fracture Risk Assessment Tool (FRAX) scores, have shown limitations in assessing fracture risk Type 2 Diabetes (T2D), underscoring the need for novel biomarkers and suggesting that other pathomechanisms may drive diabetic bone fragility. MicroRNAs (miRNAs) are secreted into circulation from cells of various tissues proportional to local disease severity were recently found be crucial homeostasis T2D. Here, we studied, if which circulating miRNAs or...
To evaluate whether T2 relaxation time measurements obtained at 3 T MRI predict the onset of radiographic knee osteoarthritis (OA).We performed a nested case-control study incident OA in Osteoarthritis Initiative cohort. Cases were 50 knees with baseline Kellgren-Lawrence (KL) grade 0 that developed KL 2 or more over 4-year period. Controls 80 after 4 years follow-up. Baseline and laminar analysis deep superficial layers all compartments. The association values was assessed logistic...
Background Osteoarthritis (OA), a multifactorial disease causing joint degeneration, often leads to severe disability. The rising rates of disability highlight the need for implementing preventative measures at early stages disease, which would especially benefit subjects high risk OA development. Purpose To develop prediction tool moderate‐severe (TOARP) over 8 years based on subject characteristics, knee radiographs, and MRI data baseline using from Initiative (OAI). Study Type...
To study the cross-sectional association between physical activity measured with an accelerometer, structural knee abnormalities, and cartilage T2 values assessed 3T magnetic resonance imaging (MRI).We included 274 subjects from Osteoarthritis Initiative cohort without definite radiographic osteoarthritis (Kellgren/Lawrence grades 0 1) at most mild pain, stiffness, functional limitation in (Western Ontario McMaster Universities Index scale 0-1), which had not limited their due to pain....
To assess lesion detection and artifact size reduction of a multiacquisition variable-resonance image combination, slice encoding for metal correction (MAVRIC-SEMAC) hybrid sequence (MAVRIC-SL) compared to standard sequences at 1.5T 3T in porcine knee specimens with hardware.Artificial cartilage bone lesions defined were created the proximity titanium steel screws 2.5 mm diameter 12 imaged magnetic resonance imaging (MRI) MAVRIC-SL PD short T1 inversion recovery (STIR), fast spin echo (FSE)...
Purpose To investigate the association of presence and severity diabetes mellitus (DM) with articular cartilage composition, using magnetic resonance imaging (MRI)‐based T 2 relaxation time measurements, structural knee abnormalities. Materials Methods In Osteoarthritis Initiative 208, participants DM (age 63.0 ± 8.9 years; 111 females) risk factors for osteoarthritis (OA) or mild radiographic tibiofemoral OA (Kellgren–Lawrence [KL] grade ≤2) were identified group‐matched 208 controls...
Although one study showed minimal progression of erosions in patients with rheumatoid arthritis (RA) year after TNFα inhibition therapy, no studies have investigated very early bone changes initiation anti-TNFα treatment. We the effects 3-month treatment on erosion and microarchitecture RA using high-resolution peripheral quantitative computed tomography (HR-pQCT). Patients (n = 27) (17 10 MTX-only group) underwent assessment disease activity score 28 joints (DAS-28), radiographs, 3-T...
Introduction Diabetic bone disease is characterized by an increased fracture risk which may be partly attributed to deficits in cortical quality such as higher porosity. However, the temporal evolution of microarchitecture, strength, and particularly porosity diabetic still unknown. Here, we aimed prospectively characterize 5-year changes type 2 (T2D) postmenopausal women with (DMFx) without history fragility fractures (DM) compare those nondiabetic free controls (Co) using high resolution...
This study is to evaluate highly accelerated three‐dimensional (3D) dynamic contrast‐enhanced (DCE) wrist MRI for assessment of perfusion in rheumatoid arthritis (RA) patients. A pseudo‐random variable‐density undersampling strategy, circular Cartesian (CIRCUS), was combined with k–t SPARSE‐SENSE reconstruction achieve a 3D DCE MRI. Two healthy volunteers and 10 RA patients were studied. on methotrexate (MTX) only (Group I) the other eight treated combination therapy MTX anti‐tumor necrosis...