A5059597975- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Atrial Fibrillation Management and Outcomes
- Neurological Disorders and Treatments
- Cerebral Venous Sinus Thrombosis
- Neurological Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Hospital Admissions and Outcomes
- Cardiovascular Health and Disease Prevention
- Sepsis Diagnosis and Treatment
- Neurological and metabolic disorders
- Chronic Kidney Disease and Diabetes
- Renal and Vascular Pathologies
- Peripheral Artery Disease Management
- Cellular Mechanics and Interactions
- S100 Proteins and Annexins
- Intracranial Aneurysms: Treatment and Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Moyamoya disease diagnosis and treatment
- Energy Efficiency and Management
Helsinki University Hospital
2016-2025
University of Helsinki
2016-2025
Population Health Research Institute
2024
McMaster University
2024
University of Zurich
2020-2023
University of Lausanne
2013-2023
University Hospital of Bern
2016-2023
Prevention Institute
2020
Heidelberg University
2017-2020
University Hospital Heidelberg
2017-2020
The time to initiate intravenous thrombolysis for acute ischemic stroke is generally limited within 4.5 hours after the onset of symptoms. Some trials have suggested that treatment window may be extended in patients who are shown but not yet infarcted brain tissue on imaging.
The purpose of this study was to provide a simple and practical clinical classification for the etiology intracerebral hemorrhage (ICH).We performed retrospective chart review consecutive patients with ICH treated at Helsinki University Central Hospital, January 2005 March 2010 (n=1013). We classified by predefined criteria as structural vascular lesions (S), medication (M), amyloid angiopathy (A), systemic disease hypertension (H), or undetermined (U). Clinical radiological features...
International guidelines recommend avoiding intravenous thrombolysis (IVT) in patients with ischemic stroke who have a recent intake of direct oral anticoagulant (DOAC). To determine the risk symptomatic intracranial hemorrhage (sICH) associated use IVT DOAC ingestion. This international, multicenter, retrospective cohort study included 64 primary and comprehensive centers across Europe, Asia, Australia, New Zealand. Consecutive adult received (both without thrombectomy) were included....
Numerous contraindications included in the license of alteplase, most which are not based on scientific evidence, restrict portion patients with acute ischemic stroke eligible for treatment alteplase. We studied whether off-label thrombolysis was associated poorer outcome or increased rates symptomatic intracerebral hemorrhage compared on-label use.All consecutive treated intravenous from 1995 to 2008 at Helsinki University Central Hospital were registered (n=1104). After excluding basilar...
Background and Purpose— Seizures are a common complication of intracerebral hemorrhage (ICH). We developed novel tool to quantify this risk in individual patients. Methods— Retrospective analysis the observational Helsinki ICH Study (n=993; median follow-up, 2.7 years) Lille Prognosis InTra-Cerebral Hemorrhage (n=325; 2.2 cohorts consecutive patients admitted between 2004 2010. patients’ province-wide electronic records were evaluated for early seizures occurring within 7 days among 7-day...
Although many stroke patients are young or middle-aged, risk factor profiles in these age groups poorly understood.The Stroke Young Fabry Patients (sifap1) study prospectively recruited a large multinational European cohort of with cerebrovascular events aged 18 to 55 years establish their prevalence disease. In secondary analysis ischemic transient attack, we studied age- and sex-specific prevalences various factors.Among 4467 (median age, 47 years; interquartile range, 40-51), the most...
Background and Purpose— Data on mortality its prognostic factors after an acute ischemic stroke in young adults are scarce based relatively small heterogeneous patient series. Methods— We analyzed 5-year data of all consecutive patients aged 15 to 49 with first-ever treated at the Department Neurology, Helsinki University Central Hospital, from January 1994 September 2003. followed up using registry Statistics Finland. used life table analyses for calculating risks. Kaplan-Meier method...
Background and Purpose— Treating ischemic stroke with thrombolytic therapy is effective safe, but limited data exist on its efficacy safety in different etiologic subtypes. Methods— Patients acute treated intravenous thrombolysis between 1995 2008 at our hospital were classified according to the Trial of ORG 10172 Acute Stroke Treatment criteria based diagnostic evaluation. Clinical outcome subtypes by 3-month modified Rankin Scale was compared multivariate logistic regression. A good...
Background Recent studies have shown an increasing prevalence of vascular risk factors in young adults with ischemic stroke ( IS ). However, the strength association between all and early‐onset has not been fully established. Methods Results We compared 961 patients a first‐ever at 25 to 49 years 1403 frequency‐matched stroke‐free controls from population‐based cohort study FINRISK Assessed included active malignancy, atrial fibrillation, cardiovascular disease, current smoking status,...
Background and Purpose— We compared outcome complications in patients with stroke treated intravenous thrombolysis (IVT) who could not live alone without help of another person before (dependent patients) versus independent ones. Methods— In a multicenter IVT-register–based cohort study, we previously dependent (prestroke modified Rankin Scale score, 3–5) 0–2) patients. Outcome measures were poor 3-month (not reaching at least prestroke [dependent patients]; score 3–6 [independent...
Neurocritical illness is a growing healthcare problem with profound socioeconomic effects. We assessed differences in costs and long-term outcome for different forms of neurocritical illnesses treated the intensive care unit (ICU).We used prospective Finnish Intensive Care Consortium database to identify all adult patients traumatic brain injury (TBI), intracerebral hemorrhage (ICH), subarachnoid (SAH) acute ischemic stroke (AIS) at university hospital ICUs Finland during 2003-2013. Outcome...
<b><i>Background:</i></b> Depression and depression-executive dysfunction syndrome (DES) are common neuropsychiatric consequences of stroke. We hypothesized that if stroke as a cerebrovascular event causes depression, this so-called post-stroke depression will further increase the risk recurrent The objective study was to investigate whether patients with or DES have increased rates recurrence. <b><i>Methods:</i></b> included 223 from Helsinki...
Women have a worse outcome after stroke compared with men, although in intravenous thrombolysis (IVT)-treated patients, women seem to benefit more. Besides sex differences, age has also possible effect on functional outcome. The interaction of the IVT-treated patients relation remains complex. purpose this study was compare IVT between and men regard large multicenter European cohort reflecting daily clinical practice acute care.Data were obtained from registries 12 tertiary hospitals....
Background and Purpose— It is unclear whether blood lipid profiles statin use before intracerebral hemorrhage (ICH) are associated with its outcome. Methods— The Helsinki ICH Study, a single-center observational registry of consecutive patients, was used to study the associations between premorbid use, baseline levels, clinical Results— includes 964 patients. Statin users (n=187; 19%) were significantly older, had more frequent comorbidities medication, lower higher admission Glasgow Coma...
To evaluate whether pretreatment with metformin (MET) is associated less stroke severity and better outcome after IV thrombolysis (IVT), we analyzed a cohort of 1,919 patients type 2 diabetes mellitus in multicenter exploratory analysis.Data from ischemic treated IVT were collected within the European Thrombolysis Ischemic Stroke Patients (TRISP) collaboration. We applied propensity score matching (PSM) to obtain balanced baseline characteristics without MET.Of who underwent IVT, 757 (39%)...
Plasma glial fibrillary acidic protein (GFAP) and tau are promising markers for differentiating acute cerebral ischemia (ACI) hemorrhagic stroke (HS), but their prehospital dynamics usefulness unknown.We performed ultra-sensitivite single-molecule array (Simoa®) measurements of plasma GFAP total in a code patient cohort with cardinal symptoms [National Institutes Health Stroke Scale (NIHSS) ≥3]. Sequential sampling included 2 ultra-early samples, follow-up sample on the next morning.We 272...
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Objective To investigate whether poststroke dementia (PSD) diagnosed after ischaemic stroke predicts recurrent in long-term follow-up. Methods We included 486 consecutive patients with (388 first-ever stroke) admitted to Helsinki University Central Hospital who were followed-up for 12 years. Dementia was 115 using the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition (DSM-III) criteria. The effects risk factors PSD on survival free estimated Kaplan–Meier log-rank analyses,...
Background and Purpose— Cerebral white matter lesions (WMLs), a surrogate for small-vessel disease, are common in patients with stroke may be related to an increased intracranial bleeding risk after intravenous thrombolysis acute ischemic stroke. We aimed investigate the of symptomatic intracerebral hemorrhage (sICH) presence WMLs large cohort treated thrombolysis. Methods— included 2485 consecutive at Helsinki University Central Hospital. were scored according 4 previously published...
<h3>Objective</h3> To study the effect of platelet count (PC) on bleeding risk and outcome in stroke patients treated with IV thrombolysis (IVT) to explore whether withholding IVT PC < 100 × 10<sup>9</sup>/L is supported. <h3>Methods</h3> In this prospective multicenter, register–based study, we compared symptomatic intracranial hemorrhage (sICH; Second European-Australasian Acute Stroke Study [ECASS II] criteria), poor (modified Rankin Scale score 3–6), mortality at 3 months. was used as...
Impairment of executive functions (EFs) is a common cognitive symptom post-stroke and affects independence in daily activities. Previous studies have often relied on brief tests not fully considering the wide spectrum EF subdomains. A detailed assessment EFs was used to examine which subdomains strongest predictive value functional outcome institutionalization long-term follow-up.A subsample 62 patients from Helsinki Stroke Aging Memory Study evaluated with battery seven neuropsychological 3...
Primary bovine osteoblasts and human osteosarcoma cells exposed to direct-current electric fields undergo processes of retraction elongation ultimately resulting in the realignment long cellular axis perpendicular field. The time taken for this reorientation was inversely correlated field strength within a certain range. Cellular force output during analyzed using simple modification traction microscopy. first detectable reaction an increase average magnitude occurring between 10 30 seconds...