Bruno Gonçalves
A5040217959- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Acute Ischemic Stroke Management
- COVID-19 and healthcare impacts
- Frailty in Older Adults
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac Arrest and Resuscitation
- Thermal Regulation in Medicine
- Nosocomial Infections in ICU
- Antibiotic Resistance in Bacteria
- Venous Thromboembolism Diagnosis and Management
- Family and Patient Care in Intensive Care Units
- Health Systems, Economic Evaluations, Quality of Life
- Neurosurgical Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
- Retinal and Optic Conditions
- Vasculitis and related conditions
- Vascular Malformations Diagnosis and Treatment
- Antibiotic Use and Resistance
- Cardiovascular and Diving-Related Complications
Instituto Estadual do Cérebro Paulo Niemeyer
2016-2025
Hospital Sírio-Libanês
2024
Centre Hospitalier Sainte-Anne
2023
Heinrich Heine University Düsseldorf
2021-2022
Center for Neurosciences
2021
FHU Neurovasc
2020-2021
Université Paris Cité
2020-2021
Délégation Paris 5
2021
Inserm
2020-2021
Sorbonne Université
2021
Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that strokes are typically associated with poor prognosis can be very efficiently treated recanalization techniques, confirmation this putative is urgently warranted in large representative patient cohort to alert stroke clinicians, inform pre- in-hospital pathways. We pooled all consecutive patients hospitalized...
Abstract Background The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due large numbers patients being admitted into hospitals. One potential prognostic indicators in with is frailty. degree frailty could be used assist both triage intensive care, and decisions regarding treatment limitations. Our study sought determine interaction age elderly ICU patients. Methods A prospective multicentre ≥ 70 years care 138 ICUs from 28 countries was conducted....
Background and Purpose: Stroke is reported as a consequence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in several reports. However, data are sparse regarding the details these patients multinational large scale. Methods: We conducted observational study on features consecutive ischemic stroke, intracranial hemorrhage, cerebral venous or sinus thrombosis among SARS-CoV-2–infected patients. further investigated risk vessel occlusion, stroke severity measured by...
To define the incidence of ventriculostomy-associated infections and their impact on mortality functional outcomes patients with aneurysmal subarachnoid hemorrhage. We prospectively included all consecutive adult hemorrhage admitted to neurological intensive care units Instituto Estadual do Cérebro Paulo Niemeyer (Rio de Janeiro, Brazil) Hospital Cristo Redentor Grande Sul, who required external ventricular drains from July 2015 December 2020. Daily clinical laboratory variables were...
To investigate in routine care the efficacy and safety of IV thrombolysis (IVT) with tenecteplase prior to mechanical thrombectomy (MT) patients large vessel occlusion acute ischemic strokes (LVO-AIS), either secondarily transferred after IVT or directly admitted a comprehensive stroke center (CSC).We retrospectively analyzed clinical procedural data treated 0.25 mg/kg within 270 minutes LVO-AIS who underwent brain angiography. The main outcome was 3-month functional independence (modified...
The primary aim of this study was to assess the outcome elderly intensive care unit (ICU) patients treated during spring and autumn COVID-19 surges in Europe.This a prospective European observational (the COVIP study) ICU aged 70 years older admitted with disease from March December 2020 159 ICUs 14 countries. An electronic database used register number parameters including: SOFA score, Clinical Frailty Scale, co-morbidities, usual procedures survival at 90 days. registered...
[Figure: see text].
Abstract Background Noninvasive ventilation (NIV) is a promising alternative to invasive mechanical (IMV) with particular importance amidst the shortage of intensive care unit (ICU) beds during COVID-19 pandemic. We aimed evaluate use NIV in Europe and factors associated outcomes patients treated NIV. Methods This substudy COVIP study—an international prospective observational study enrolling aged ≥ 70 years confirmed ICU. enrolled 156 ICUs across 15 European countries between March 2020...
Acute ischemic stroke (AIS) and thrombotic events (TEs) were reported in patients with COVID-19. Clinical outcome of AIS the course COVID-19 remains unknown. We compared early clinical mortality COVID-positive (+) admitted for COVID-negative (-) ones. hypothesized that COVID+ would have poorer outcomes present a higher rate TEs COVID- ones.In this multicentric observational retrospective study, we enrolled over 18 years old 3 units Parisian region during lockdown from March 17, 2020, to May...
Background: Convalescent plasma is a potential therapeutic option for critically ill patients with coronavirus disease 19 (COVID-19), yet its efficacy remains to be determined. The aim was investigate the effects of convalescent (CP) in COVID-19. Methods: This single-center prospective observational study conducted Rio de Janeiro, Brazil, from March 17th May 30th, final follow-up on June 30th. We included 113 laboratory-confirmed COVID-19 respiratory failure. Primary outcomes were time...
Aneurysmal subarachnoid hemorrhage (SAH) is an acute cerebrovascular disease associated with high mortality and long-term functional impairment among survivors. Systemic inflammatory responses after injury nosocomial infections are frequent complications, making the management of these patients challenging. Here, we hypothesized that sepsis might be early outcomes. Our objective was to define incidence sepsis, diagnosed prospectively Sepsis-3 criteria, determine its impact on outcomes SAH....
Abstract Objectives Critically ill patients with COVID-19 may suffer from a cytokine release syndrome (CRS) characterized by remarkably high levels of interleukin 6 (IL-6). We assessed the effects tocilizumab, an IL-6 receptor antagonist, on intra-hospital mortality and development positive cultures in admitted to ICU. Design Patients COVID 19 ICU who were treated tocilizumab plus standard care enrolled compared controls. Setting severe disease Interventions Tocilizumab 400 mg IV two doses....
Abstract Background Stroke is reported as a consequence of SARS-CoV-2 infection. However, there lack regarding comprehensive stroke phenotype and characteristics Methods We conducted multinational observational study on features consecutive acute ischemic (AIS), intracranial hemorrhage (ICH), cerebral venous or sinus thrombosis (CVST) among infected patients. further investigated the association demographics, clinical data, geographical regions, countries’ health expenditure AIS patients...
Abstract Background health-related quality of life (HRQoL) is an important patient-centred outcome in patients surviving ICU admission for COVID-19. It currently not clear which domains the HRQoL are most affected. Objective to quantify order identify areas interventions. Design prospective observation study. Setting admissions European ICUs between March 2020 and February 2021. Subjects aged 70 years or older admitted with COVID-19 disease. Methods collected determinants include SOFA-score,...
We report a series of three cases admitted to the intensive care unit (ICU) Paulo Niemeyer State Brain Institute due severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), all developing distress (ARDS) and renal failure, later in course disease, catastrophic intracerebral hemorrhages.Clinical characteristics patients are described Table 1.
Abstract Background In the early COVID-19 pandemic concerns about correct choice of analgesics in patients with were raised. Little data was available on potential usefulness or harmfulness prescription free analgesics, such as paracetamol. This international multicentre study addresses that lack evidence regarding harm paracetamol intake prior to ICU admission a setting disease within large, prospectively enrolled cohort critically ill and frail intensive care unit (ICU) patients. Methods...
As of mid-June 2020, 7,500,000 people were infected with SARS-CoV-2 worldwide and 420,000 died, mainly from coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS). COVID-19-related ARDS is subject to a mortality rate 50% prolonged period mechanical ventilation, no specific pharmacological treatment currently available (Infection au nouveau Coronavirus (SARS-CoV-2), COVID-19, France et Monde. https://www.santepubliquefrance.fr/dossiers/coronavirus-covid-19 )....