Stéphane Legriel
A5003719412- Cardiac Arrest and Resuscitation
- Epilepsy research and treatment
- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory Support and Mechanisms
- Pharmacological Effects and Toxicity Studies
- Thermal Regulation in Medicine
- Sepsis Diagnosis and Treatment
- Neurological Complications and Syndromes
- Neonatal and fetal brain pathology
- Trauma and Emergency Care Studies
- Traumatic Brain Injury Research
- Cardiac, Anesthesia and Surgical Outcomes
- EEG and Brain-Computer Interfaces
- Long-Term Effects of COVID-19
- Family and Patient Care in Intensive Care Units
- Airway Management and Intubation Techniques
- Mechanical Circulatory Support Devices
- Brain Metastases and Treatment
- Infectious Encephalopathies and Encephalitis
- Bacterial Infections and Vaccines
- Neuroscience and Neuropharmacology Research
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Moyamoya disease diagnosis and treatment
Centre Hospitalier de Versailles
2016-2025
Hôpital André Mignot
2015-2025
Inserm
2016-2025
Université Paris-Saclay
2020-2025
Université de Versailles Saint-Quentin-en-Yvelines
2020-2025
Centre de recherche en Epidémiologie et Santé des Populations
2020-2025
Intensive Care Society
2016-2024
Maternité Port Royal
2023
Paris Cardiovascular Research Center
2016-2022
Université Paris Cité
2007-2022
Moderate therapeutic hypothermia is currently recommended to improve neurologic outcomes in adults with persistent coma after resuscitated out-of-hospital cardiac arrest. However, the effectiveness of moderate patients nonshockable rhythms (asystole or pulseless electrical activity) debated.
An increased proportion of deaths occur in the intensive care unit (ICU). We performed this prospective study 41 ICUs to determine prevalence and determinants complicated grief after death a loved one ICU. Relatives 475 adult patients were followed up. Complicated was assessed at 6 12 months using Inventory Grief (cut-off score >25). also completed Hospital Anxiety Depression Scale 3 months, Revised Impact Event for post-traumatic stress disorder symptoms 3, months. used mixed...
<h3>Importance</h3> Although an emergency coronary angiogram (CAG) is recommended for patients who experience out-of-hospital cardiac arrest (OHCA) with ST-segment elevation on the postresuscitation electrocardiogram (ECG), this strategy still debated in without elevation. <h3>Objective</h3> To assess 180-day survival rate Cerebral Performance Category (CPC) 1 or 2 of OHCA ECG and undergo CAG vs delayed CAG. <h3>Design, Setting, Participants</h3> The Emergency Delayed Coronary Angiogram...
Despite advances in care, mortality and morbidity remain high adults with acute bacterial meningitis, particularly when due to Streptococcus pneumoniae. Induced hypothermia is beneficial other conditions global cerebral hypoxia.To test the hypothesis that induced improves outcome patients severe meningitis.An open-label, multicenter, randomized clinical trial 49 intensive care units France, February 2009-November 2011. In total, 130 were assessed for eligibility 98 comatose (Glasgow Coma...
Objective Few outcome data are available about posterior reversible encephalopathy syndrome (PRES). We studied 90-day functional outcomes and their determinants in patients with severe PRES. Design 70 PRES admitted to 24 ICUs 2001–2010 were included a retrospective cohort study. The main measure was Glasgow Outcome Scale (GOS) of 5 (good recovery) on day 90. Main Results Consciousness impairment the most common clinical sign, occurring 66 (94%) patients. Clinical seizures occurred 57 (81%)...
Convulsive status epilepticus often results in permanent neurologic impairment. We evaluated the effect of induced hypothermia on outcomes patients with convulsive epilepticus.In a multicenter trial, we randomly assigned 270 critically ill who were receiving mechanical ventilation to (32 34°C for 24 hours) addition standard care or alone; 268 included analysis. The primary outcome was good functional at 90 days, defined as Glasgow Outcome Scale (GOS) score 5 (range, 1 5, representing death...
Patients who are treated with targeted temperature management after out-of-hospital cardiac arrest shockable rhythm at increased risk for ventilator-associated pneumonia. The benefit of preventive short-term antibiotic therapy has not been shown.
Few outcome data are available about convulsive status epilepticus managed in the intensive care unit. We studied 90-day functional outcomes and their determinants patients with epilepticus.Two hundred forty-eight admitted to 18 units 2005-2007 were included a prospective observational cohort study. The main measure was Glasgow Outcome Scale score of 5 (good recovery) on day 90.Convulsive occurred out hospital 177 (67%) patients, all but 15 still seizing at medical team arrival. median time...
Objectives: Although sudden cardiac death has been broadly studied, little is known on cerebrovascular events revealed by out-of-hospital arrest. We aimed to describe clinical features and prognosis of these patients identify characteristics that could suggest a etiology the Design: Retrospective review (1999–2012) databases three regional referral ICU centers for Setting: Patients admitted management successfully resuscitated Patients: were included when subarachnoid hemorrhage,...
Abstract Introduction The widespread use of highly active antiretroviral therapy (ART) has reduced HIV-related life-threatening infectious complications. Our objective was to assess whether ART associated with improved survival in critically ill HIV-infected patients. Methods A retrospective study from 1996 2005 performed a medical intensive care unit (ICU) university hospital specialized the management immunocompromised total 284 patients were included. Differences sought across four time...
Relatives often lack important information about intensive care unit patients. High-quality is crucial to help relatives overcome the considerable situational stress and acquire ability participate in decision-making process, most notably regarding appropriate level of care. We aimed develop a list questions for patients unit.This was multicenter study. Questions asked by were collected from five different sources (literature, panel 28 nurses physicians, 1-wk survey physicians 14 units,...
Abstract Background Recognizing infection is crucial in immunocompromised patients with organ dysfunction. Our objective was to assess the diagnostic accuracy of procalcitonin (PCT) critically ill patients. Methods This prospective, observational study included suspected sepsis. Patients were classified into one three groups: no infection, bacterial sepsis, and nonbacterial Results We 119 a median age 54 years (interquartile range [IQR], 42-68 years). The general severity (SAPSII)...