Neill K. J. Adhikari
A5046860959- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Acute Kidney Injury Research
- Family and Patient Care in Intensive Care Units
- Disaster Response and Management
- Emergency and Acute Care Studies
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Hemodynamic Monitoring and Therapy
- Vitamin C and Antioxidants Research
- Nosocomial Infections in ICU
- Health Systems, Economic Evaluations, Quality of Life
- Neonatal Respiratory Health Research
- Viral Infections and Outbreaks Research
- Meta-analysis and systematic reviews
- Chronic Kidney Disease and Diabetes
- Traumatic Brain Injury and Neurovascular Disturbances
- Global Maternal and Child Health
- Dialysis and Renal Disease Management
- Electronic Health Records Systems
- Climate Change and Health Impacts
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Long-Term Effects of COVID-19
University of Toronto
2016-2025
Sunnybrook Health Science Centre
2016-2025
Health Sciences Centre
2016-2025
Brigham and Women's Hospital
2025
Harvard University
2008-2025
Massachusetts General Hospital
2008-2025
Sunnybrook Research Institute
2012-2025
Post Graduate Medical Institute
2025
Institute of Medical Sciences
2025
Public Health Ontario
2019-2024
Section:ChooseTop of pageAbstract <<ContentsOverviewIntroductionMethodsRecommendations for Speci...ConclusionsReferencesCITING ARTICLES
Acute kidney injury is common in critically ill patients, many of whom receive renal-replacement therapy. However, the most effective timing for initiation such therapy remains uncertain.
Meta-analysis handles randomized trials with no outcome events in both treatment and control arms inconsistently, including them when risk difference (RD) is the effect measure but excluding relative (RR) or odds ratio (OR) are used. This study examined influence of such on pooled effects. Analysis without zero total event three illustrative published meta-analyses a range proportions trials, effects, heterogeneity using inverse variance weighting random effects that incorporates...
<h3>Importance</h3> Tracheal intubation is one of the most commonly performed and high-risk interventions in critically ill patients. Limited information available on adverse peri-intubation events. <h3>Objective</h3> To evaluate incidence nature events to assess current practice <h3>Design, Setting, Participants</h3> The International Observational Study Understand Impact Best Practices Airway Management Critically Ill Patients (INTUBE) study was an international, multicenter, prospective...
Few resources are available to support caregivers of patients who have survived critical illness; consequently, the caregivers' own health may suffer. We studied caregiver and patient characteristics determine which were associated with outcomes during first year after discharge from an intensive care unit (ICU).We prospectively enrolled 280 had received 7 or more days mechanical ventilation in ICU. Using hospital data self-administered questionnaires, we collected information on...
Over the past two decades, use of noninvasive positive-pressure ventilation and continuous positive airway pressure by mask has increased substantially for acutely ill patients.Initial case series uncontrolled cohort studies that suggested benefit in selected patients 1-13 led to many randomized controlled trials (RCTs). Both thods have been used setting acute respiratory failure avoid endotracheal intubation different patient populations settings, with variable success....
Disability risk groups and 1-year outcome after greater than or equal to 7 days of mechanical ventilation (MV) in medical/surgical intensive care unit (ICU) patients are unknown may inform education, prognostication, rehabilitation, study design.To stratify for post-ICU disability recovery 1 year critical illness.We evaluated a multicenter cohort 391 ICU who received week MV at 3, 6, 12 months discharge. were identified using recursive partitioning modeling.The 7-day Functional Independence...
Meta-analysis of continuous outcomes traditionally uses mean difference (MD) or standardized (SMD; in pooled standard deviation (SD) units). We recently used an alternative ratio values (RoM) method, calculating RoM for each study and estimating its variance by the delta method. SMD allow pooling expressed different units comparisons effect sizes across interventions, but interpretation does not require knowledge SD, a quantity generally unknown to clinicians. To evaluate performance...