A5040689704- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Airway Management and Intubation Techniques
- Neonatal Respiratory Health Research
- Hemodynamic Monitoring and Therapy
- Nosocomial Infections in ICU
- Electrical and Bioimpedance Tomography
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Family and Patient Care in Intensive Care Units
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tracheal and airway disorders
- Non-Invasive Vital Sign Monitoring
- Acute Kidney Injury Research
- Immune Response and Inflammation
- Thermal Regulation in Medicine
- Adrenal Hormones and Disorders
University Hospital Bonn
2016-2025
University of Bonn
2012-2024
University of Zurich
2024
Medizinische Hochschule Hannover
2021
University of Amsterdam
2015-2021
Université de Montpellier
2021
Monash University
2021
Uppsala University Hospital
2021
Universitätsmedizin Göttingen
2021
Centre National de la Recherche Scientifique
2021
Improved gas exchange has been observed during spontaneous breathing with airway pressure release ventilation (APRV) as compared controlled mechanical ventilation. This study was designed to determine whether use of APRV a primary ventilatory support modality better prevents deterioration cardiopulmonary function than does initial in patients at risk for acute respiratory distress syndrome (ARDS). Thirty multiple trauma were randomly assigned either breathe spontaneously (APRV Group) (n =...
Ventilation–perfusion (V˙ a/Q˙) distributions were evaluated in 24 patients with acute respiratory distress syndrome (ARDS), during airway pressure release ventilation (APRV) and without spontaneous breathing, or support (PSV). Whereas PSV provides mechanical assistance of each inspiration, APRV allows unrestricted breathing throughout the ventilation. Patients randomly assigned to receive equal limits (Paw) (n = 12) minute e) 12). In both groups was associated increases (p < 0.05) right...
<h3>Importance</h3> Tracheal intubation is one of the most commonly performed and high-risk interventions in critically ill patients. Limited information available on adverse peri-intubation events. <h3>Objective</h3> To evaluate incidence nature events to assess current practice <h3>Design, Setting, Participants</h3> The International Observational Study Understand Impact Best Practices Airway Management Critically Ill Patients (INTUBE) study was an international, multicenter, prospective...
<h3>Objectives</h3> The objective of this preliminary study was to explore long-term changes in neurobehavioral parameters, brain morphology and electroencephalography sepsis patients who received intensive care compared non-septic unit (ICU) patients. <h3>Methods</h3> Two-centre follow-up 6–24 months after discharge from hospital using published norms existing databases healthy controls for comparison. Patients included 25 septic 19 ICU survivors were recruited two ICUs a university...
Objective We report on the effect of hemoadsorption therapy to reduce cytokines in septic patients with respiratory failure. Methods This was a randomized, controlled, open-label, multicenter trial. Mechanically ventilated severe sepsis or shock and acute lung injury distress syndrome were eligible for study inclusion. Patients randomly assigned either CytoSorb hemoperfusion 6 hours per day up 7 consecutive days (treatment), no (control). Primary outcome change normalized IL-6-serum...
High-dose intravenous administration of sodium selenite has been proposed to improve outcome in sepsis by attenuating oxidative stress. Procalcitonin-guided antimicrobial therapy may hasten the diagnosis sepsis, but effect on is unclear.To determine whether high-dose treatment and procalcitonin-guided anti-infectious patients with severe affect mortality.The Placebo-Controlled Trial Sodium Selenite Procalcitonin Guided Antimicrobial Therapy Severe Sepsis (SISPCT), a multicenter, randomized,...
Although current guidelines suggest the use of regional citrate anticoagulation (which involves addition a solution to blood before filter extracorporeal dialysis circuit) as first-line treatment for continuous kidney replacement therapy in critically ill patients, evidence this recommendation is based on few clinical trials and meta-analyses.To determine effect anticoagulation, compared with systemic heparin life span mortality.A parallel-group, randomized multicenter trial 26 centers...
Early appropriate antimicrobial therapy leads to lower mortality rates associated with severe sepsis. The role of empirical combination comprising at least 2 antibiotics different mechanisms remains controversial.To compare the effect moxifloxacin and meropenem alone on sepsis-related organ dysfunction.A randomized, open-label, parallel-group trial 600 patients who fulfilled criteria for sepsis or septic shock (n = 298 monotherapy n 302 therapy). was performed 44 intensive care units in...
BackgroundHypercapnic respiratory failure in patients with COPD frequently requires mechanical ventilatory support. Extracorporeal CO2 removal (ECCO2R) techniques have not been systematically evaluated these patients.MethodsThis is a pilot study of novel ECCO2R device that utilizes single venous catheter high rates at low blood flows. Twenty hypercapnic received ECCO2R. Group 1 (n = 7) consisted receiving noninvasive ventilation likelihood requiring invasive ventilation, group 2 2) who could...
Postoperative delirium (POD) occurs frequently after cardiac surgery and is associated with increased morbidity mortality. We analysed whether perioperative bilateral BIS monitoring may detect abnormalities before the onset of POD in patients. In a prospective observational study, 81 patients undergoing were included. Bilateral Bispectral Index (BIS)-monitoring was applied during pre-, intra- postoperative period, BIS, EEG Asymmetry (ASYM), Burst Suppression Ratio (BSR) recorded. diagnosed...
Rationale: Cardiovascular instability/collapse is a common peri-intubation event in patients who are critically ill. Objectives: To identify potentially modifiable variables associated with cardiovascular (i.e., systolic arterial pressure <65 mm Hg [once] or <90 for >30 minutes; new/increased vasopressor requirement; fluid bolus >15 ml/kg, cardiac arrest). Methods: INTUBE (International Observational Study to Understand the Impact and Best Practices of Airway Management In Critically Ill...
To provide further evidence for the efficacy and safety of drotrecogin alfa (activated) treatment in severe sepsis.Single-arm, open-label, trial sepsis patients. Enrollment began March 2001 day-28 follow-up completed January 2003.ENHANCE took place 25 countries at 361 sites.Patients with known or suspected infection, three four systemic inflammatory response syndrome criteria, one more sepsis-induced organ dysfunctions. Of 2,434 adults entered, 2,378 received (activated), these, 2,375...
It is not clear whether the mechanical properties of respiratory system assessed under dynamic condition ventilation are equivalent to those static conditions. We hypothesized that analyses and mechanics provide different information in acute failure.Prospective multiple-center study.Intensive care units eight German university hospitals.A total 28 patients with lung injury distress syndrome.None.Dynamic were determined during ongoing an incremental positive end-expiratory pressure (PEEP)...
Background Mechanical ventilation with high tidal volumes (V(T)) in contrast to mechanical low V(T) has been shown increase plasma levels of proinflammatory and antiinflammatory mediators patients acute lung injury. The authors hypothesized that, without previous injury, a conventional potentially injurious ventilatory strategy zero end-expiratory pressure (ZEEP) will not cause cytokine release into systemic circulation. Methods A total 39 American Society Anesthesiologists physical status...
In Brief Mechanical ventilation with high tidal volumes (VT) and zero or low positive end-expiratory pressure increased mediator release to inflammatory stimuli acute lung injury. We studied whether mechanical modifies the responses during major thoracic abdominal surgery. Sixty-four patients undergoing elective thoracotomy (n = 34) laparotomy 30) were randomized receive either VT 12 15 mL/kg ideal body weight, respectively, pressure, 6 weight of 10 cm H2O. 62 who completed study, arterial...
Increased plasma levels of atrial natriuretic peptide (ANP) and brain (BNP) have been identified as predictors cardiac dysfunction prognosis in congestive heart failure ischemic disease. In severe sepsis patients, however, no information is available yet about the prognostic value peptides. Therefore, aim present study was to determine role N-terminal prohormone forms ANP (NT-proANP) BNP (NT-proBNP) context outcome septic patients. Furthermore, effect treatment with recombinant human...
Objective: To describe and compare characteristics, ventilatory practices, associated outcomes among mechanically ventilated patients with different types of brain injury between neurologic nonneurologic patients. Design: Secondary analysis a prospective, observational, multicenter study on mechanical ventilation. Setting: Three hundred forty-nine intensive care units from 23 countries. Patients: We included 552 (362 stroke 190 trauma). For comparison we used control group 4,030 mixed who...