A5086839301- Spaceflight effects on biology
- High Altitude and Hypoxia
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Stress Responses and Cortisol
- Acute Kidney Injury Research
- Cannabis and Cannabinoid Research
- Immune Response and Inflammation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Adrenal Hormones and Disorders
- Muscle and Compartmental Disorders
- Medical and Biological Ozone Research
- Anesthesia and Neurotoxicity Research
- Electrolyte and hormonal disorders
- Long-Term Effects of COVID-19
- Climate Change and Health Impacts
- Organ Transplantation Techniques and Outcomes
- Neuroscience of respiration and sleep
- Adenosine and Purinergic Signaling
- COVID-19 Clinical Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Pain Mechanisms and Treatments
- Renal function and acid-base balance
- Circadian rhythm and melatonin
LMU Klinikum
2009-2024
München Klinik
2013-2024
München Klinik Neuperlach
2015-2022
Luzerner Kantonsspital
2020
Olgahospital
2020
Ludwig-Maximilians-Universität München
2006-2019
Ontario Medical Association
2008-2016
Zero to Three
2008-2014
Novem (Netherlands)
2014
Institut für Urheber- und Medienrecht
2011-2013
High-dose intravenous administration of sodium selenite has been proposed to improve outcome in sepsis by attenuating oxidative stress. Procalcitonin-guided antimicrobial therapy may hasten the diagnosis sepsis, but effect on is unclear.To determine whether high-dose treatment and procalcitonin-guided anti-infectious patients with severe affect mortality.The Placebo-Controlled Trial Sodium Selenite Procalcitonin Guided Antimicrobial Therapy Severe Sepsis (SISPCT), a multicenter, randomized,...
A substantial number of individuals are at risk for the development motion sickness induced nausea and vomiting (N&V) during road, air or sea travel. Motion can be extremely stressful but neurobiologic mechanisms leading to not clear. The endocannabinoid system (ECS) represents an important neuromodulator stress N&V. Inhibitory effects ECS on N&V mediated by endocannabinoid-receptor activation.We studied activity in human volunteers (n = 21) parabolic flight maneuvers (PFs). During PFs,...
Abstract Septic shock is a common medical condition with mortality approaching 50% where early diagnosis and treatment are of particular importance for patient survival. Novel biomarkers that serve as prompt indicators sepsis urgently needed. High‐throughput technologies assessing circulating micro RNA s represent an important tool biomarker identification, but the blood‐compartment specificity these mi has not yet been investigated. We characterized profiles from serum exosomes, total blood...
Space flight exerts a specific conglomerate of stressors on humans that can modulate the immune system. The mechanism remains to be elucidated and consequences for cosmonauts in long term are unclear. Most current research stems from short-term spaceflights as well pre- post-flight analyses due operational limitations. Immune function 12 participating long-duration (>140days) spaceflight mission was monitored pre-, post-, two time-points in-flight. While classical markers stress such...
Glucocorticoids play a major role in the consolidation and retrieval of traumatic information. They act through glucocorticoid receptor, for which, humans, several polymorphisms have been described. In particular, BclI single-nucleotide polymorphism is associated with hypersensitivity to glucocorticoids susceptibility development depression. Furthermore, patients posttraumatic stress disorder carrying GG genotype, cortisol levels were lower showed an inverse relationship symptom intensity....
In general, the liver is considered to be larger in males than females. present study, data on weight from 728 legal autopsies were analyzed with respect gender, age, body height (BH), (BW), mass index (BMI), and surface area (BSA). Descriptive statistics revealed that increases reaching maximum values between 41 50 years men 51 60 women. Thereafter, decreases again. Because this loss starts earlier while continues rise women, difference women lost above age of 50. Thus, defines a threshold...
Production of oxygen radicals is required for both microbicidal and tissue-toxic effector functions granulocytes. Inasmuch as an ambivalent role polymorphonuclear leukocytes (PMNs) may become apparent during sepsis, we studied levels hydrogen peroxide (H2O2) production by PMNs depending upon the nature different particulate soluble stimuli in patients with increasing sepsis severity. Patients (n = 15), severe 12), or septic shock 33) were prospectively enrolled study. Healthy volunteers...
Background: Severe systemic inflammation (systemic inflammatory response syndrome) associated with cardiac surgery often leads to a worse short-term and long-term outcome. Stress doses of hydrocortisone have been successfully used improve outcome CS. The interleukin (IL)-6 IL-10 ratio is after trauma major surgery. Objective: To evaluate immunologic effects (especially IL-6 ratio) stress in high-risk group patients cardiopulmonary bypass. Design: Prospective, randomized, double-blinded,...
The endocannabinoid system (ECS) plays an important role in the regulation of physiological functions, from stress and memory to vegetative control immunity. ECS is considered a central peripheral response emotional or physical challenges acts through endocannabinoids (ECs), which bind their receptors inducing subsequent effecting mechanisms. In our studies, responses have been assessed blood concentrations ECs anandamide 2-arachidonoylglycerol. parallel, saliva cortisol was determined...
Abstract Cell‐free microRNAs (miRNAs) are transferred in disease state including inflammatory lung diseases and often packed into extracellular vesicles (EVs). To assess their suitability as biomarkers for community‐acquired pneumonia (CAP) severe secondary complications such sepsis, we studied patients with CAP (n = 30), sepsis 65) healthy volunteers 47) subdivided a training 67) validation 75) cohort. After precipitating crude EVs from sera, associated small RNA was profiled by...
The aim of this study was to characterize the systemic cytokine signature critically ill COVID-19 patients in a high mortality setting aiming identify biomarkers severity, and explore their associations with viral loads clinical characteristics. We studied two patient cohorts from referral centre located Central Europe. were recruited during pre-alpha/alpha (November 2020 April 2021) delta (end period respectively. determined both serum bronchoalveolar SARS-CoV-2 load identified variant...
<i>Background:</i> The complex regional pain syndrome (CRPS) and fibromyalgia (FM) are chronic syndromes occurring in highly stressed individuals. Despite the known connection between nervous system immune cells, information on distribution of lymphocyte subsets under stress conditions is limited. <i>Methods:</i> We performed a comparative study 15 patients with CRPS type I, 22 FM 37 age- sex-matched healthy controls investigated influence number, subpopulations...
Liver ischemia-reperfusion injury (IRI) is a known risk factor for the postoperative outcome of patients undergoing liver surgery/transplantation. Attempts to protect from organ damage require multidisciplinary strategies and are emerging interest in view with higher age American Society Anesthesiology status. Ischemic preconditioning has been successfully applied prevent IRI during resection/transplantation. Because even short periods ischemia inevitably lead hypoxia formation...
Whole body exposure of wild type control littermates and A2A adenosine receptor (A2AR) gene deleted mice to low oxygen containing inspired gas mixture allowed the investigation mechanism that controls inflammatory liver damage protects using a mouse model T cell-mediated viral autoimmune hepatitis. We tested hypothesis tissue damage-associated hypoxia extracellular --> A2AR signaling plays an important role in physiological anti-inflammatory limits during fulminant After induction hepatitis,...
<b>Objective</b> To describe the characteristics at enrolment and outcomes of doctors in a substance dependence monitoring programme Canada. <b>Design</b> Prospective descriptive study. <b>Setting</b> Provincial physician health programme, <b>Participants</b> All 100 consecutively admitted to followed until completion or on leaving programme. <b>Main outcome measure</b> Relapse during long term for five years. <b>Results</b> Ninety per cent enrolled were men, 66% married living with partner,...
Background Epinephrine enhances emotional memory whereas β-adrenoceptor antagonists (β-blockers, BBs) impair it. However, the effects of BB administration on are sex dependent. Therefore, we predicted differential epinephrine and metoprolol given to male female patients after cardiac surgery (CS) traumatic memories post-traumatic stress disorder (PTSD) symptoms. Method We performed a prospective observational study determined number standardized (NTRM) PTSD symptom intensity in surgical at 1...
The complex regional pain syndrome (CRPS) is a disabling neuropathic condition that may develop following injuries of the extremities. pathogenesis this not clear; however, it includes interactions between nervous and immune system resulting in chronic inflammation, trophic changes. This interaction be mediated by stress which thought to activate endogenous cannabinoid (endocannabinoid) (ECS). We conducted an open, prospective, comparative clinical study determine plasma level...